{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:39:02Z","timestamp":1771861142391,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A plasmonic sensing platform was developed as a noninvasive method to monitor gas-phase biomarkers related to cystic fibrosis (CF). The nanohole array (NHA) sensing platform is based on localized surface plasmon resonance (LSPR) and offers a rapid data acquisition capability. Among the numerous gas-phase biomarkers that can be used to assess the lung health of CF patients, acetaldehyde was selected for this investigation. Previous research with diverse types of sensing platforms, with materials ranging from metal oxides to 2-D materials, detected gas-phase acetaldehyde with the lowest detection limit at the \u00b5mol\/mol (parts-per-million (ppm)) level. In contrast, this work presents a plasmonic sensing platform that can approach the nmol\/mol (parts-per-billion (ppb)) level, which covers the required concentration range needed to monitor the status of lung infection and find pulmonary exacerbations. During the experimental measurements made by a spectrometer and by a smartphone, the sensing examination was initially performed in a dry air background and then with high relative humidity (RH) as an interferent, which is relevant to exhaled breath. At a room temperature of 23.1 \u00b0C, the lowest detection limit for the investigated plasmonic sensing platform under dry air and 72% RH conditions are 250 nmol\/mol (ppb) and 1000 nmol\/mol (ppb), respectively.<\/jats:p>","DOI":"10.3390\/s21113776","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T03:45:29Z","timestamp":1622432729000},"page":"3776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasmonic Sensing Studies of a Gas-Phase Cystic Fibrosis Marker in Moisture Laden Air"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-9634","authenticated-orcid":false,"given":"Libin","family":"Sun","sequence":"first","affiliation":[{"name":"School of Engineering and Applied Science, George Washington University, Washington, DC 20052, USA"},{"name":"Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-074X","authenticated-orcid":false,"given":"Drew A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Jacobs School of Engineering, University of California, San Diego, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt D.","family":"Benkstein","sequence":"additional","affiliation":[{"name":"Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Semancik","sequence":"additional","affiliation":[{"name":"Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona E.","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"School of Engineering and Applied Science, George Washington University, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/EDE.0000000000000920","article-title":"Dynamic Prediction of Survival in Cystic Fibrosis: A Landmarking Analysis using UK Patient Registry Data","volume":"30","author":"Keogh","year":"2019","journal-title":"Epidemiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/thoraxjnl-2015-208123","article-title":"Advancing Clinical Development Pathways for New CFTR Modulators in Cystic Fibrosis","volume":"71","author":"Boyle","year":"2016","journal-title":"Thorax"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1093\/hmg\/ddy188","article-title":"Recent Advances in Developing Therapeutics for Cystic Fibrosis","volume":"27","author":"Strug","year":"2018","journal-title":"Hum. 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