{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:13:18Z","timestamp":1760235198115,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A respiratory measurement system composed of pressure and airflow sensors was introduced to precisely control the respiratory condition during animal experiments. The flow sensor was a hot-wire thermal airflow meter with a directional detection and airflow temperature change compensation function based on MEMS technology, and the pressure sensor was a commercially available one also produced by MEMS. The artificial dead space in the system was minimized to the value of 0.11 mL by integrating the two sensors on the same plate (26.0 mm \u00d7 15.0 mm). A balloon made of a silicone resin with a hardness of A30 was utilized as the simulated lung system and applied to the elasticity evaluation of the respiratory system in a living rat. The inside of the respiratory system was normally pressurized without damage, and we confirmed that the developed system was able to evaluate the elasticity of the lung tissue in the rat by using the pressure value obtained at the quasi-static conditions in the case of the ventilation in the animal experiments.<\/jats:p>","DOI":"10.3390\/s21155123","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T21:21:04Z","timestamp":1627507264000},"page":"5123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Miniaturization of Respiratory Measurement System in Artificial Ventilator for Small Animal Experiments to Reduce Dead Space and Its Application to Lung Elasticity Evaluation"],"prefix":"10.3390","volume":"21","author":[{"given":"Homare","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Biomedical Information Sciences, Hiroshima City University, Hiroshima 731-3194, Japan"}]},{"given":"Yoshihiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Information Sciences, Hiroshima City University, Hiroshima 731-3194, Japan"}]},{"given":"Miyoko","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Division of Host Defense Sciences, Omics Health Sciences, Department of Integrated Health Sciences, Graduate School of Medicine, Nagoya University, Nagoya 461-0047, Japan"}]},{"given":"Tomoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Graduate School of Medicine, Nagoya University, Nagoya 466-8560, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-9930","authenticated-orcid":false,"given":"Tsutomu","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Division of Host Defense Sciences, Omics Health Sciences, Department of Integrated Health Sciences, Graduate School of Medicine, Nagoya University, Nagoya 461-0047, Japan"}]},{"given":"Mitsuhiro","family":"Shikida","sequence":"additional","affiliation":[{"name":"Department of Biomedical Information Sciences, Hiroshima City University, Hiroshima 731-3194, Japan"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1097\/SMJ.0b013e3181bfac4f","article-title":"Basic Invasive Mechanical Ventilation","volume":"102","author":"Singer","year":"2009","journal-title":"South Med. 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