{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:17:45Z","timestamp":1773011865004,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej","doi-asserted-by":"publisher","award":["Homing\/2017-4\/38"],"award-info":[{"award-number":["Homing\/2017-4\/38"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A direct verification of the three-dimensional (3D) proton clinical treatment plan prepared for tumor in the eyeball, using the Eclipse Ocular Proton Planning system (by Varian Medical Systems), has been presented. To achieve this, a prototype of the innovative two-dimensional (2D) circular silicone foils, made of a polymer with the embedded optically stimulated luminescence (OSL) material in powder form (LiMgPO4), and a self-developed optical imaging system, consisting of an illuminating light source and a high-sensitive CCD camera has been applied. A specially designed lifelike eyeball phantom has been used, constructed from 40 flat sheet LMP-based silicone foils stacked and placed together behind a spherical phantom made by polystyrene, all to reflect the curvature of the real eyeball. Two-dimensional OSL signals were captured and further analyzed from each single silicone foil after irradiation using a dedicated patient collimator and a 58.8 MeV modulated proton beam. The reconstructed 3D proton depth dose distribution matches very well with the clinical treatment plan, allowing for the consideration of the new OSL system for further 3D dosimetry applications within the proton radiotherapy area.<\/jats:p>","DOI":"10.3390\/s21186015","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T21:28:45Z","timestamp":1631136525000},"page":"6015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["3D Dosimetry Based on LiMgPO4 OSL Silicone Foils: Facilitating the Verification of Eye-Ball Cancer Proton Radiotherapy"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-7623","authenticated-orcid":false,"given":"Micha\u0142","family":"S\u0105del","sequence":"first","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-5145","authenticated-orcid":false,"given":"Jan","family":"Gajewski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Urszula","family":"Sowa","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Jan","family":"Swako\u0144","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Tomasz","family":"Kajdrowicz","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-3404","authenticated-orcid":false,"given":"Pawe\u0142","family":"Bilski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Mariusz","family":"K\u0142osowski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Anna","family":"P\u0119dracka","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]},{"given":"Tomasz","family":"Horwacik","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1118\/1.2804555","article-title":"Characterization of optically stimulated luminescent dosimeters, OSLDs, for clinical dosimetric measurements","volume":"34","author":"Jursinic","year":"2007","journal-title":"Med. Phys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1088\/0031-9155\/56\/18\/018","article-title":"Optically stimulated luminescencein vivodosimetry for radiotherapy: Physical characterization and clinical measurements in60Co beams","volume":"56","author":"Izewska","year":"2011","journal-title":"Phys. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"081720","DOI":"10.1118\/1.4890795","article-title":"Validation of OSLD and a treatment planning system for surface dose determination in IMRT treatments","volume":"41","author":"Zhuang","year":"2014","journal-title":"Med. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.phro.2019.08.004","article-title":"Dosimetric impact of placement errors in optically stimulated luminescent in vivo dosimetry in radiotherapy","volume":"11","author":"Tariq","year":"2019","journal-title":"Phys. Imaging Radiat. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1109\/TNS.2004.839299","article-title":"Quality control of intensity modulated radiation therapy with optically stimulated luminescent films","volume":"51","author":"Idri","year":"2004","journal-title":"IEEE Trans. Nucl. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.radmeas.2011.06.044","article-title":"Progress in 2D-OSL-dosimetry with beryllium oxide","volume":"46","author":"Jahn","year":"2011","journal-title":"Radiat. Meas."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1088\/0031-9155\/59\/8\/1899","article-title":"Two-dimensional high spatial-resolution dosimeter using europium doped potassium chloride: A feasibility study","volume":"59","author":"Li","year":"2014","journal-title":"Phys. Med. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.radmeas.2014.01.009","article-title":"Development of a 2D dosimetry system based on the optically stimulated luminescence of Al2O3","volume":"71","author":"Ahmed","year":"2014","journal-title":"Radiat. Meas."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1088\/0031-9155\/61\/21\/7551","article-title":"Characterization of Al2O3optically stimulated luminescence films for 2D dosimetry using a 6 MV photon beam","volume":"61","author":"Ahmed","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"012044","DOI":"10.1088\/1742-6596\/847\/1\/012044","article-title":"Three-dimensional radiation dosimetry based on optically-stimulated luminescence","volume":"847","author":"Sadel","year":"2017","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.radmeas.2019.02.014","article-title":"Optically stimulated luminescence of LiF: Mg,Cu,P with different dopant concentrations","volume":"123","author":"Bilski","year":"2019","journal-title":"Radiat. Meas."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/rpd\/ncz055","article-title":"Optically stimulated luminescence of LiF: Mg, Cu, P powder\u2014influence of thermal treatment","volume":"186","author":"Bilski","year":"2019","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106293","DOI":"10.1016\/j.radmeas.2020.106293","article-title":"A new approach to the 2D radiation dosimetry based on optically stimulated luminescence of LiF: Mg,Cu,P","volume":"133","author":"Bilski","year":"2020","journal-title":"Radiat. Meas."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.radmeas.2016.01.028","article-title":"New OSL detectors based on LiMgPO4 crystals grown by micro pulling down method. Dosimetric properties vs. growth parameters","volume":"90","author":"Gieszczyk","year":"2016","journal-title":"Radiat. Meas."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.radmeas.2017.04.004","article-title":"Comparative studies on OSL properties of LiMgPO4:Tb,B powders and crystals","volume":"106","author":"Kulig","year":"2017","journal-title":"Radiat. Meas."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radmeas.2018.03.007","article-title":"Thermoluminescent response of differently doped lithium magnesium phosphate (LiMgPO4, LMP) crystals to protons, neutrons and alpha particles","volume":"113","author":"Gieszczyk","year":"2018","journal-title":"Radiat. Meas."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106205","DOI":"10.1016\/j.radmeas.2019.106205","article-title":"OSL and RL of LiMgPO4 crystals doped with rare earth elements","volume":"129","author":"Marczewska","year":"2019","journal-title":"Radiat. Meas."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106255","DOI":"10.1016\/j.radmeas.2020.106255","article-title":"Two-dimensional radiation dosimetry based on LiMgPO4 powder embedded into silicone elastomer matrix","volume":"133","author":"Bilski","year":"2020","journal-title":"Radiat. Meas."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.nimb.2011.05.001","article-title":"LiMgPO4:Tb,B\u2014A new sensitive OSL phosphor for dosimetry","volume":"269","author":"Dhabekar","year":"2011","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. Atoms"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"012067","DOI":"10.1088\/1742-6596\/573\/1\/012067","article-title":"A new dosimeter formulation for deformable 3D dose verification","volume":"573","author":"Skyt","year":"2015","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.radmeas.2010.06.020","article-title":"Facility for proton radiotherapy of eye cancer at IFJ PAN in Krakow","volume":"45","author":"Swakon","year":"2010","journal-title":"Radiat. Meas."},{"key":"ref_22","unstructured":"IAEA TRS 398 (2000). Absorbed Dose Determination in External Beam Radiotherapy, Absorbed Dose Water IAEA."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_24","unstructured":"Gajewski, J. (2021, August 01). FREDtools\u2014Radiotherapy Image Analysis in Python. Available online: www.fredtools.ifj.edu.pl."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fphy.2020.578605","article-title":"Implementation of a Compact Spot-Scanning Proton Therapy System in a GPU Monte Carlo Code to Support Clinical Routine","volume":"8","author":"Gajewski","year":"2020","journal-title":"Front. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fphy.2020.567300","article-title":"Commissioning of GPU\u2013Accelerated Monte Carlo Code FRED for Clinical Applications in Proton Therapy","volume":"8","author":"Gajewski","year":"2021","journal-title":"Front. Phys."},{"key":"ref_27","first-page":"112","article-title":"Relative TL and OSL efficiency to protons of various dosimetric materials","volume":"161","author":"Bilski","year":"2013","journal-title":"Radiat. Prot. Dosim."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/18\/6015\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:51Z","timestamp":1760165931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/18\/6015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":27,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["s21186015"],"URL":"https:\/\/doi.org\/10.3390\/s21186015","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}