{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:48:42Z","timestamp":1781534922765,"version":"3.54.5"},"reference-count":66,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Cognitive workload is a crucial factor in tasks involving dynamic decision-making and other real-time and high-risk situations. Neuroimaging techniques have long been used for estimating cognitive workload. Given the portability, cost-effectiveness and high time-resolution of EEG as compared to fMRI and other neuroimaging modalities, an efficient method of estimating an individual\u2019s workload using EEG is of paramount importance. Multiple cognitive, psychiatric and behavioral phenotypes have already been known to be linked with \u201cfunctional connectivity\u201d, i.e., correlations between different brain regions. In this work, we explored the possibility of using different model-free functional connectivity metrics along with deep learning in order to efficiently classify the cognitive workload of the participants. To this end, 64-channel EEG data of 19 participants were collected while they were doing the traditional n-back task. These data (after pre-processing) were used to extract the functional connectivity features, namely Phase Transfer Entropy (PTE), Mutual Information (MI) and Phase Locking Value (PLV). These three were chosen to do a comprehensive comparison of directed and non-directed model-free functional connectivity metrics (allows faster computations). Using these features, three deep learning classifiers, namely CNN, LSTM and Conv-LSTM were used for classifying the cognitive workload as low (1-back), medium (2-back) or high (3-back). With the high inter-subject variability in EEG and cognitive workload and recent research highlighting that EEG-based functional connectivity metrics are subject-specific, subject-specific classifiers were used. Results show the state-of-the-art multi-class classification accuracy with the combination of MI with CNN at 80.87%, followed by the combination of PLV with CNN (at 75.88%) and MI with LSTM (at 71.87%). The highest subject specific performance was achieved by the combinations of PLV with Conv-LSTM, and PLV with CNN with an accuracy of 97.92%, followed by the combination of MI with CNN (at 95.83%) and MI with Conv-LSTM (at 93.75%). The results highlight the efficacy of the combination of EEG-based model-free functional connectivity metrics and deep learning in order to classify cognitive workload. The work can further be extended to explore the possibility of classifying cognitive workload in real-time, dynamic and complex real-world scenarios.<\/jats:p>","DOI":"10.3390\/s21206710","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:37:49Z","timestamp":1633901869000},"page":"6710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Subject-Specific Cognitive Workload Classification Using EEG-Based Functional Connectivity and Deep Learning"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-8780","authenticated-orcid":false,"given":"Anmol","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, Indian Institute of Technology, Roorkee 247667, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-3863","authenticated-orcid":false,"given":"Gourav","family":"Siddhad","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Indian Institute of Technology, Roorkee 247667, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-3015","authenticated-orcid":false,"given":"Vishal","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Delhi 110054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-5254","authenticated-orcid":false,"given":"Partha Pratim","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Indian Institute of Technology, Roorkee 247667, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-3464","authenticated-orcid":false,"given":"Byung-Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of IT Engineering, Sookmyung Women\u2019s University, Seoul 04310, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15326985EP3801_1","article-title":"Cognitive load theory and instructional design: Recent developments","volume":"38","author":"Paas","year":"2003","journal-title":"Educ. 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