{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:45:06Z","timestamp":1761061506447,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"publisher","award":["ETH-30 14-2"],"award-info":[{"award-number":["ETH-30 14-2"]}],"id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012652","name":"ETH Z\u00fcrich Foundation","doi-asserted-by":"publisher","award":["2015-03"],"award-info":[{"award-number":["2015-03"]}],"id":[{"id":"10.13039\/501100012652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","award":["Einrichungskredit"],"award-info":[{"award-number":["Einrichungskredit"]}],"id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Society Industry Fellowship","award":["IF170011"],"award-info":[{"award-number":["IF170011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70\/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2mm and an inner diameter of 114mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system\u2019s Coincidence Resolving Time (CRT) and energy resolution are between separate-uncertainty 209.0(3)ps and separate-uncertainty 12.41(02) Full Width at Half Maximum (FWHM) at low activity and separate-uncertainty 326.89(12)ps and separate-uncertainty 20.630(011) FWHM at 550MBq, respectively. The peak sensitivity is \u223c1.6. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be \u223c2mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET\/MR image acquisitions with time frames of a few seconds in length at activities of up to 500MBq.<\/jats:p>","DOI":"10.3390\/s21217037","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:07:11Z","timestamp":1635113231000},"page":"7037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-130X","authenticated-orcid":false,"given":"Pascal","family":"Bebi\u00e9","sequence":"first","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Robert","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Volker","family":"Commichau","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Jan","family":"Debus","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"G\u00fcnther","family":"Dissertori","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Lubomir","family":"Djambazov","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Afroditi","family":"Eleftheriou","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-0220","authenticated-orcid":false,"given":"Jannis","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9808-3574","authenticated-orcid":false,"given":"Peter","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute of Computer Engineering, Heidelberg University, 69120 Heidelberg, Germany"}]},{"given":"Mikiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Parisa","family":"Khateri","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-2217","authenticated-orcid":false,"given":"Werner","family":"Lustermann","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-8907","authenticated-orcid":false,"given":"Christian","family":"Ritzer","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Michael","family":"Ritzert","sequence":"additional","affiliation":[{"name":"Institute of Computer Engineering, Heidelberg University, 69120 Heidelberg, Germany"}]},{"given":"Ulf","family":"R\u00f6ser","sequence":"additional","affiliation":[{"name":"Institute for Particle Physics and Astrophysics, ETH Z\u00fcrich, 8093 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-2477","authenticated-orcid":false,"given":"Charalampos","family":"Tsoumpas","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK"}]},{"given":"Geoffrey","family":"Warnock","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}]},{"given":"Bruno","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-3424","authenticated-orcid":false,"given":"Matthias T.","family":"Wyss","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Z\u00fcrich, 8057 Z\u00fcrich, 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