{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:30:22Z","timestamp":1760236222712,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["20-01589S"],"award-info":[{"award-number":["20-01589S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Highly stable, small-sized and evenly distributed solid mercury nanoparticles capped with ibuprofen (Ibu-HgNPs) were prepared via reduction with hydrazine and capped with ibuprofen as a stabilizing agent. Characterization of Ibu-HgNPs was carried out by UV-Vis spectrophotometry and transmission electron microscopy (TEM). The prepared Ibu-HgNPs were immobilized onto a glassy carbon electrode (GCE) and used for the first time as the sensing element for voltammetric determination of low concentrations of acrylamide (AA) in aqueous solutions. Various parameters such as the type of supporting electrolyte, voltammetric mode, frequency, deposition time, stirring rate and initial potential were optimized to obtain the highest peak current of AA. The sensor delivered the best results in combination with the square wave voltammetry (SWV) mode, with good repeatability (relative standard deviation (RSD) of 25 repetitions was 1.4% for 1000 ppb AA). The study further revealed that Ibu-HgNPs are strongly adhered to GCE and hence do not contaminate the environment even after several runs. The newly developed AA sensor provides linear calibration dependence in the range of 100\u20131300 ppb with an R2 value of 0.996 and limit of detection (LOD) of 8.5 ppb. Negligible interference was confirmed from several organic compounds, cations and anions. The developed sensor was successfully applied for AA determination in various types of environmental real water samples to prove its practical usefulness and applicability.<\/jats:p>","DOI":"10.3390\/s21217302","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T22:17:23Z","timestamp":1635891443000},"page":"7302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Highly Sensitive Voltammetric Determination of Acrylamide Based on Ibuprofen Capped Mercury Nanoparticles"],"prefix":"10.3390","volume":"21","author":[{"family":"Sirajuddin","sequence":"first","affiliation":[{"name":"International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan"}]},{"given":"Zulfiqar Ali","family":"Tagar","sequence":"additional","affiliation":[{"name":"National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-4755","authenticated-orcid":false,"given":"Muhammad Anwar","family":"Ul Haq","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan"}]},{"given":"Muhammad Raza","family":"Shah","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan"}]},{"family":"Mujeeb-ur-Rehman","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan"}]},{"given":"Syed Tufail Hussain","family":"Sherazi","sequence":"additional","affiliation":[{"name":"National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-7349","authenticated-orcid":false,"given":"Jiri","family":"Barek","sequence":"additional","affiliation":[{"name":"UNESCO Laboratory of Environmental Electrochemistry, Department of Analytical Chemistry, Faculty of Science, Charles University, Albertov 6, CZ-15843 Prague, Czech Republic"}]},{"given":"Muhammad Siddique","family":"Kalhoro","sequence":"additional","affiliation":[{"name":"Institute of Physics, University of Sindh, Jamshoro 76080, Pakistan"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1021\/jf030204+","article-title":"Chemistry, biochemistry and safety of acrylamide: A Review","volume":"51","author":"Friedman","year":"2003","journal-title":"J. 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