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Spectral-domain OCT technology enables peripapillary circular scans of the retina and the measurement of the thickness of the retinal nerve fiber layer (RNFL) for the assessment of the disease status or progression in glaucoma patients. This paper describes a new approach to segment and measure the retinal nerve fiber layer in peripapillary OCT images. The proposed method consists of two stages. In the first one, morphological operators robustly detect the coarse location of the layer boundaries, despite the speckle noise and diverse artifacts in the OCT image. In the second stage, deformable models are initialized with the results of the previous stage to perform a fine segmentation of the boundaries, providing an accurate measurement of the entire RNFL. The results of the RNFL segmentation were qualitatively assessed by ophthalmologists, and the measurements of the thickness of the RNFL were quantitatively compared with those provided by the OCT inbuilt software as well as the state-of-the-art methods.<\/jats:p>","DOI":"10.3390\/s21238027","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T02:56:14Z","timestamp":1638413774000},"page":"8027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Automatic Segmentation of the Retinal Nerve Fiber Layer by Means of Mathematical Morphology and Deformable Models in 2D Optical Coherence Tomography Imaging"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-2804","authenticated-orcid":false,"given":"Rafael","family":"Berenguer-Vidal","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Polit\u00e9cnicas, Campus de los Jer\u00f3nimos, Universidad Cat\u00f3lica de Murcia UCAM, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-7397","authenticated-orcid":false,"given":"Rafael","family":"Verd\u00fa-Monedero","sequence":"additional","affiliation":[{"name":"Departamento de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Campus Muralla del Mar, Universidad Polit\u00e9cnica de Cartagena, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-3292","authenticated-orcid":false,"given":"Juan","family":"Morales-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Tecnolog\u00edas de la Informaci\u00f3n y Comunicaciones, Campus Muralla del Mar, Universidad Polit\u00e9cnica de Cartagena, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8757-2559","authenticated-orcid":false,"given":"Inmaculada","family":"Sell\u00e9s-Navarro","sequence":"additional","affiliation":[{"name":"Servicio de Oftalmolog\u00eda, Hospital General Universitario Reina Sof\u00eda, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5342-2093","authenticated-orcid":false,"given":"Roc\u00edo","family":"del Amor","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9900-886X","authenticated-orcid":false,"given":"Gabriel","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-3412","authenticated-orcid":false,"given":"Valery","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: A Systematic Review and Meta-Analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of glaucoma: Clinical and experimental concepts","volume":"40","author":"Casson","year":"2012","journal-title":"Clin. 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