{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:23:00Z","timestamp":1773843780548,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck","doi-asserted-by":"publisher","award":["Premio Innovazione Digitale nella Sclerosi Multipla"],"award-info":[{"award-number":["Premio Innovazione Digitale nella Sclerosi Multipla"]}],"id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Digital medical solutions can be very helpful in restorative neurology, as they allow the patients to practice their rehabilitation activities remotely. This work discloses ReMoVES, an IoMT system providing telemedicine services, in the context of Multiple Sclerosis rehabilitation, within the frame of the project STORMS. A rehabilitative protocol of exercises can be provided as ReMoVES services and integrated into the Individual Rehabilitation Project as designed by a remote multidimensional medical team. In the present manuscript, the first phase of the study is described, including the definition of the needs to be addressed, the employed technology, the design and the development of the exergames, and the possible practical\/professional and academic consequences. The STORMS project has been implemented with the aim to act as a starting point for the development of digital telerehabilitation solutions that support Multiple Sclerosis patients, improving their living conditions. This paper introduces a study protocol and it addresses pre-clinical research needs, where system issues can be studied and better understood how they might be addressed. It also includes tools to favor remote patient monitoring and to support the clinical staff.<\/jats:p>","DOI":"10.3390\/s21248436","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:40:32Z","timestamp":1639968032000},"page":"8436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Study Protocol for Occupational Rehabilitation in Multiple Sclerosis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-1808","authenticated-orcid":false,"given":"Marco","family":"Trombini","sequence":"first","affiliation":[{"name":"Department of Electrical, Electronics and Telecommunication Engineering and Naval Architecture (DITEN), Universit\u00e0 degli Studi di Genova, Via all\u2019Opera Pia 11a, I-16145 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-9271","authenticated-orcid":false,"given":"Federica","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronics and Telecommunication Engineering and Naval Architecture (DITEN), Universit\u00e0 degli Studi di Genova, Via all\u2019Opera Pia 11a, I-16145 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Iaconi","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronics and Telecommunication Engineering and Naval Architecture (DITEN), Universit\u00e0 degli Studi di Genova, Via all\u2019Opera Pia 11a, I-16145 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-895X","authenticated-orcid":false,"given":"Lucilla","family":"Vestito","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Children\u2019s Sciences (DINOGMI), Universit\u00e0 degli Studi di Genova, Largo Paolo Daneo 3, I-16132 Genoa, Italy"},{"name":"Ospedale Policlinico San Martino IRCCS, Largo Rosanna Benzi 10, I-16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1104-459X","authenticated-orcid":false,"given":"Fabio","family":"Bandini","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Neurologia-Ospedale Villa Scassi ASL 3, Corso Onofrio Scassi 1, I-16149 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-8327","authenticated-orcid":false,"given":"Laura","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Children\u2019s Sciences (DINOGMI), Universit\u00e0 degli Studi di Genova, Largo Paolo Daneo 3, I-16132 Genoa, Italy"},{"name":"Ospedale Policlinico San Martino IRCCS, Largo Rosanna Benzi 10, I-16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-0669","authenticated-orcid":false,"given":"Carlo","family":"Trompetto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Children\u2019s Sciences (DINOGMI), Universit\u00e0 degli Studi di Genova, Largo Paolo Daneo 3, I-16132 Genoa, Italy"},{"name":"Ospedale Policlinico San Martino IRCCS, Largo Rosanna Benzi 10, I-16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-5198","authenticated-orcid":false,"given":"Silvana","family":"Dellepiane","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronics and Telecommunication Engineering and Naval Architecture (DITEN), Universit\u00e0 degli Studi di Genova, Via all\u2019Opera Pia 11a, I-16145 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.clinph.2017.06.253","article-title":"Exploring resting-state EEG brain oscillatory activity in relation to cognitive functioning in multiple sclerosis","volume":"128","author":"Keune","year":"2017","journal-title":"Clin. 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