{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:38:15Z","timestamp":1760236695022,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Surface electromyography (EMG), typically recorded from muscle groups such as the mentalis (chin\/mentum) and anterior tibialis (lower leg\/crus), is often performed in human subjects undergoing overnight polysomnography. Such signals have great importance, not only in aiding in the definitions of normal sleep stages, but also in defining certain disease states with abnormal EMG activity during rapid eye movement (REM) sleep, e.g., REM sleep behavior disorder and parkinsonism. Gold standard approaches to evaluation of such EMG signals in the clinical realm are typically qualitative, and therefore burdensome and subject to individual interpretation. We originally developed a digitized, signal processing method using the ratio of high frequency to low frequency spectral power and validated this method against expert human scorer interpretation of transient muscle activation of the EMG signal. Herein, we further refine and validate our initial approach, applying this to EMG activity across 1,618,842 s of polysomnography recorded REM sleep acquired from 461 human participants. These data demonstrate a significant association between visual interpretation and the spectrally processed signals, indicating a highly accurate approach to detecting and quantifying abnormally high levels of EMG activity during REM sleep. Accordingly, our automated approach to EMG quantification during human sleep recording is practical, feasible, and may provide a much-needed clinical tool for the screening of REM sleep behavior disorder and parkinsonism.<\/jats:p>","DOI":"10.3390\/s22010055","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:02:57Z","timestamp":1640224977000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of Visually Identified Muscle Potentials during Human Sleep Using High Frequency\/Low Frequency Spectral Power Ratios"],"prefix":"10.3390","volume":"22","author":[{"given":"Mo H.","family":"Modarres","sequence":"first","affiliation":[{"name":"Mental Illness Research, Education and Clinical Center (MIRECC-VISN1), VA Bedford Health Care System, Bedford, MA 01730, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-6851","authenticated-orcid":false,"given":"Jonathan E.","family":"Elliott","sequence":"additional","affiliation":[{"name":"VA Portland Health Care System, Portland, OR 97239, USA"},{"name":"Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6421-5874","authenticated-orcid":false,"given":"Kristianna B.","family":"Weymann","sequence":"additional","affiliation":[{"name":"School of Nursing, Oregon Health & Science University, Portland, OR 97239, USA"}]},{"given":"Dennis","family":"Pleshakov","sequence":"additional","affiliation":[{"name":"School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA"}]},{"given":"Donald L.","family":"Bliwise","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University, Atlanta, GA 30322, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-3196","authenticated-orcid":false,"given":"Miranda M.","family":"Lim","sequence":"additional","affiliation":[{"name":"VA Portland Health Care System, Portland, OR 97239, USA"},{"name":"Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA"},{"name":"National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Portland, OR 97239, USA"},{"name":"Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA"},{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, USA"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","unstructured":"Berry, R.B., Brooks, R., Gamaldo, C.E., Harding, S.M., Marcus, C.L., Vaughn, B.V., and Tangredi, M.M. 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