{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:17:10Z","timestamp":1777443430002,"version":"3.51.4"},"reference-count":168,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62175205"],"award-info":[{"award-number":["62175205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Fujian Province","award":["2020J06009"],"award-info":[{"award-number":["2020J06009"]}]},{"name":"the Open Fund of State Key Laboratory of Applied Optics","award":["SKLAO2020001A15"],"award-info":[{"award-number":["SKLAO2020001A15"]}]},{"DOI":"10.13039\/100010166","name":"Xiamen Science and Technology Bureau","doi-asserted-by":"publisher","award":["3502Z20203006"],"award-info":[{"award-number":["3502Z20203006"]}],"id":[{"id":"10.13039\/100010166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720190010"],"award-info":[{"award-number":["20720190010"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016307","name":"NSAF","doi-asserted-by":"publisher","award":["U1830116"],"award-info":[{"award-number":["U1830116"]}],"id":[{"id":"10.13039\/501100016307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016307","name":"NSAF","doi-asserted-by":"publisher","award":["U2130112"],"award-info":[{"award-number":["U2130112"]}],"id":[{"id":"10.13039\/501100016307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Plasmonic metasurfaces have been widely used in biosensing to improve the interaction between light and biomolecules through the effects of near-field confinement. When paired with biofunctionalization, plasmonic metasurface sensing is considered as a viable strategy for improving biomarker detection technologies. In this review, we enumerate the fundamental mechanism of plasmonic metasurfaces sensing and present their detection in human tumors and COVID-19. The advantages of rapid sampling, streamlined processes, high sensitivity, and easy accessibility are highlighted compared with traditional detection techniques. This review is looking forward to assisting scientists in advancing research and developing a new generation of multifunctional biosensors.<\/jats:p>","DOI":"10.3390\/s22010133","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:06:54Z","timestamp":1640567214000},"page":"133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Plasmonic Metasurfaces for Medical Diagnosis Applications: A Review"],"prefix":"10.3390","volume":"22","author":[{"given":"Zhenbiao","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"},{"name":"State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Analysis and Measurement Center, School of Pharmaceutical Science, Xiamen University, Xiamen 361003, China"}]},{"given":"Sayed Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"}]},{"given":"Fajun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"}]},{"given":"Jiaqing","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"}]},{"given":"Qilin","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"}]},{"given":"Xueying","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"}]},{"given":"Jinfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Electromagnetic Wave Science and Detection Technology, Institute of Electromagnetics and Acoustics, Xiamen University, Xiamen 361005, China"},{"name":"State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/14786440209462857","article-title":"XLII. 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