{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:48:03Z","timestamp":1767008883556,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["108-2218-E-239-002-MY2"],"award-info":[{"award-number":["108-2218-E-239-002-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National United University","award":["111-NUUPRJ-03"],"award-info":[{"award-number":["111-NUUPRJ-03"]}]},{"name":"Taichung Veterans General Hospital\/National United University Joint Research Program","award":["111DCK0100001"],"award-info":[{"award-number":["111DCK0100001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A graphene-based surface plasmon resonance (SPR) prism coupler sensor is proposed for the rapid detection of immunoglobulin G (IgG) antibodies. The feasibility of the proposed sensor is demonstrated by measuring the IgG concentration in phantom mouse and human serum solutions over the range of 0\u2013250 ng\/mL. The results show that the circular dichroism and principal fast axis angle of linear birefringence increase in line with increases in IgG concentration over the considered range. Moreover, the proposed device has a resolution of 5\u201310 ng\/mL and a response time of less than three minutes. In general, the sensor provides a promising approach for IgG detection and has significant potential for rapid infectious viral disease testing applications.<\/jats:p>","DOI":"10.3390\/s22041362","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:40:17Z","timestamp":1644547217000},"page":"1362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Single-Layer-Graphene-Coated and Gold-Film-Based Surface Plasmon Resonance Prism Coupler Sensor for Immunoglobulin G Detection"],"prefix":"10.3390","volume":"22","author":[{"given":"Zhe-Wei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, National United University, Miaoli 36063, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-3214","authenticated-orcid":false,"given":"Thi-Thu-Hien","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, International University-Vietnam National University, Ho Chi Minh City 700000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National United University, Miaoli 36063, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hsiang","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National United University, Miaoli 36063, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-1890","authenticated-orcid":false,"given":"Quoc-Hung","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National United University, Miaoli 36063, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","first-page":"203","article-title":"Serological assays for SARS-CoV-2 infected disease: Benefits, limiations and perspecrives","volume":"22","author":"Infantino","year":"2020","journal-title":"Isr. 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