{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:32:22Z","timestamp":1785249142408,"version":"3.55.0"},"reference-count":196,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the 333 project of Jiangsu Province in 2017,  the Primary Research &amp; Development Plan of Jiangsu Province,  the Taihu Lake talent plan, the Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Scien","award":["BRA2017216, BE2018627,2020THRC-GD-7, D18003, LM201603, KFKT2018001"],"award-info":[{"award-number":["BRA2017216, BE2018627,2020THRC-GD-7, D18003, LM201603, KFKT2018001"]}]},{"name":"the National Natural Sciences Foundation of China","award":["NSFC81971511"],"award-info":[{"award-number":["NSFC81971511"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The early diagnosis of infectious diseases is critical because it can greatly increase recovery rates and prevent the spread of diseases such as COVID-19; however, in many areas with insufficient medical facilities, the timely detection of diseases is challenging. Conventional medical testing methods require specialized laboratory equipment and well-trained operators, limiting the applicability of these tests. Microfluidic point-of-care (POC) equipment can rapidly detect diseases at low cost. This technology could be used to detect diseases in underdeveloped areas to reduce the effects of disease and improve quality of life in these areas. This review details microfluidic POC equipment and its applications. First, the concept of microfluidic POC devices is discussed. We then describe applications of microfluidic POC devices for infectious diseases, cardiovascular diseases, tumors (cancer), and chronic diseases, and discuss the future incorporation of microfluidic POC devices into applications such as wearable devices and telemedicine. Finally, the review concludes by analyzing the present state of the microfluidic field, and suggestions are made. This review is intended to call attention to the status of disease treatment in underdeveloped areas and to encourage the researchers of microfluidics to develop standards for these devices.<\/jats:p>","DOI":"10.3390\/s22041620","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:23:29Z","timestamp":1645431809000},"page":"1620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":271,"title":["Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges"],"prefix":"10.3390","volume":"22","author":[{"given":"Shih-Mo","family":"Yang","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangsong","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-8769","authenticated-orcid":false,"given":"Wenjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-8012","authenticated-orcid":false,"given":"Yubao","family":"Cui","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Affiliated Wuxi People\u2019s Hospital, Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/2472630320950248","article-title":"The Virological, immunological, and imaging approaches for COVID-19 diagnosis and research","volume":"25","author":"Tan","year":"2020","journal-title":"SLAS Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bios.2018.03.018","article-title":"Automatic smartphone-based microfluidic biosensor system at the point of care","volume":"110","author":"Xu","year":"2018","journal-title":"Biosens. 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