{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:53:53Z","timestamp":1782978833919,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The impact of neurodegenerative disorders is twofold; they affect both quality of life and healthcare expenditure. In the case of Parkinson\u2019s disease, several strategies have been attempted to support the pharmacological treatment with rehabilitation protocols aimed at restoring motor function. In this scenario, the study of upper limb control mechanisms is particularly relevant due to the complexity of the joints involved in the movement of the arm. For these reasons, it is difficult to define proper indicators of the rehabilitation outcome. In this work, we propose a methodology to analyze and extract an ensemble of kinematic parameters from signals acquired during a complex upper limb reaching task. The methodology is tested in both healthy subjects and Parkinson\u2019s disease patients (N = 12), and a statistical analysis is carried out to establish the value of the extracted kinematic features in distinguishing between the two groups under study. The parameters with the greatest number of significances across the submovements are duration, mean velocity, maximum velocity, maximum acceleration, and smoothness. Results allowed the identification of a subset of significant kinematic parameters that could serve as a proof-of-concept for a future definition of potential indicators of the rehabilitation outcome in Parkinson\u2019s disease.<\/jats:p>","DOI":"10.3390\/s22051708","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:35:00Z","timestamp":1645569300000},"page":"1708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Statistical Analysis and Kinematic Assessment of Upper Limb Reaching Task in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-515X","authenticated-orcid":false,"given":"Alfonso Maria","family":"Ponsiglione","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80125 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-6432","authenticated-orcid":false,"given":"Carlo","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80125 Naples, Italy"},{"name":"Institute of Care and Scientific Research of Telese of ICS Maugeri SPA SB, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-3139","authenticated-orcid":false,"given":"Francesco","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80125 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cesarelli","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80125 Naples, Italy"},{"name":"Institute of Care and Scientific Research of Telese of ICS Maugeri SPA SB, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-5900","authenticated-orcid":false,"given":"Giuseppe","family":"Cesarelli","sequence":"additional","affiliation":[{"name":"Institute of Care and Scientific Research of Telese of ICS Maugeri SPA SB, 82037 Telese Terme, Italy"},{"name":"Department of Chemical, Materials and Production Engineering, University of Naples Federico II, 80125 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"D\u2019Addio","sequence":"additional","affiliation":[{"name":"Institute of Care and Scientific Research of Telese of ICS Maugeri SPA SB, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/jnr.24579","article-title":"Mirror Neurons and Their Relationship with Neurodegenerative Disorders","volume":"98","author":"Farina","year":"2020","journal-title":"J. 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