{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:25:20Z","timestamp":1783488320546,"version":"3.55.0"},"reference-count":133,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Many studies have addressed electrochemical biosensors because of their simple synthesis process, adjustability, simplification, manipulation of materials\u2019 compositions and features, and wide ranges of detection of different kinds of biomedical analytes. Performant electrochemical biosensors can be achieved by selecting materials that enable faster electron transfer, larger surface areas, very good electrocatalytic activities, and numerous sites for bioconjugation. Several studies have been conducted on the metal\u2013organic frameworks (MOFs) as electrode modifiers for electrochemical biosensing applications because of their respective acceptable properties and effectiveness. Nonetheless, researchers face challenges in designing and preparing MOFs that exhibit higher stability, sensitivity, and selectivity to detect biomedical analytes. The present review explains the synthesis and description of MOFs, and their relative uses as biosensors in the healthcare sector by dealing with the biosensors for drugs, biomolecules, as well as biomarkers with smaller molecular weight, proteins, and infectious disease.<\/jats:p>","DOI":"10.3390\/s22062238","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T02:56:20Z","timestamp":1647312980000},"page":"2238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A Comprehensive Review of Metal\u2013Organic Framework: Synthesis, Characterization, and Investigation of Their Application in Electrochemical Biosensors for Biomedical Analysis"],"prefix":"10.3390","volume":"22","author":[{"given":"Zahra","family":"Dourandish","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman 7616913439, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Tajik","sequence":"additional","affiliation":[{"name":"Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Beitollahi","sequence":"additional","affiliation":[{"name":"Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 7631885356, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman Mohammadzadeh","family":"Jahani","sequence":"additional","affiliation":[{"name":"School of Medicine, Bam University of Medical Sciences, Bam 7661771967, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba Garkani","family":"Nejad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman 7616913439, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iran","family":"Sheikhshoaie","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman 7616913439, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-726X","authenticated-orcid":false,"given":"Antonio","family":"Di Bartolomeo","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisica \u201cE.R. 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