{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:29:01Z","timestamp":1780680541469,"version":"3.54.1"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772068"],"award-info":[{"award-number":["31772068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019ZBXC090"],"award-info":[{"award-number":["2019ZBXC090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zibo-Sdut Integration Development Project","award":["31772068"],"award-info":[{"award-number":["31772068"]}]},{"name":"Zibo-Sdut Integration Development Project","award":["2019ZBXC090"],"award-info":[{"award-number":["2019ZBXC090"]}]},{"name":"Shandong Provincial Science and Technology (Lu-Yu Science and Technology Cooperation)","award":["31772068"],"award-info":[{"award-number":["31772068"]}]},{"name":"Shandong Provincial Science and Technology (Lu-Yu Science and Technology Cooperation)","award":["2019ZBXC090"],"award-info":[{"award-number":["2019ZBXC090"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>According to the chemiluminescence characteristics of the luminol-hydrogen peroxide (H2O2) system, this work designed a novel and effective electrochemiluminescence (ECL) aptasensor to detect atrazine (ATZ) rapidly. Silver nanoparticles (AgNPs) could effectively catalyze the decomposition of H2O2 and enhance the ECL intensity of the luminol-H2O2 system. Once ATZ was modified on the aptasensor, the ECL intensity was significantly weakened because of the specific combination between ATZ and its aptamer. Therefore, the changes in ECL intensity could be used to detect the concentration of ATZ. Under optimal detecting conditions, the aptasensor had a wide linear range from 1 \u00d7 10\u22123 ng\/mL to 1 \u00d7 103 ng\/mL and a low limit of detection (3.3 \u00d7 10\u22124 ng\/mL). The designed aptasensor had the advantages of good stability, reproducibility, and specificity. The aptasensor could be used to detect the ATZ content of tap water, soil, and cabbage and had satisfactory results. This work effectively constructs a novel, effective, and rapid ECL aptasensor for detecting ATZ in actual samples.<\/jats:p>","DOI":"10.3390\/s22093430","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T07:08:58Z","timestamp":1651475338000},"page":"3430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effective Electrochemiluminescence Aptasensor for Detection of Atrazine Residue"],"prefix":"10.3390","volume":"22","author":[{"given":"Xue","family":"Huang","sequence":"first","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 266 Xincun Xilu, Zibo 255049, China"},{"name":"Zibo City Key Laboratory of Agricultural Product Safety Traceability, No. 266 Xincun Xilu, Zibo 255049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.snb.2014.07.003","article-title":"Multivariate optimization of square wave voltammetry using bismuth film electrode to determine atrazine","volume":"203","author":"Bia","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.snb.2015.05.009","article-title":"Selective QCM sensor based on ATZ imprinted polymer: Its application to wastewater sample","volume":"218","author":"Gupta","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1016\/j.watres.2010.05.032","article-title":"Pan-European survey on the occurrence of selected polar organic persistent pollutants in ground water","volume":"44","author":"Loos","year":"2010","journal-title":"Water Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11356-010-0431-y","article-title":"Still present after all these years: Persistence plus potential toxicity raise questions about the use of atrazine. Environ","volume":"18","author":"Jablonowski","year":"2011","journal-title":"Sci. Pollut. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jcis.2011.01.002","article-title":"Adsorption of ATZ azine from aqueous electrolyte solutions on humic acid and silica","volume":"356","author":"Kovaios","year":"2011","journal-title":"J. Colloid. Interface. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.chroma.2006.10.003","article-title":"Multiwalled carbon nanotubes coated fibers for solid-phase microextraction of polybrominated diphenyl ethers in water and milk samples before gas chromatography with electron-capture detection","volume":"1137","author":"Wang","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2006.05.010","article-title":"Dispersive liquid-liquid microextraction combined with gas chromatography-flame photometric detection Very simple, rapid and sensitive method for the determination of organophosphorus pesticides in water","volume":"1123","author":"Berijani","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.talanta.2015.09.015","article-title":"Label-free disposable immunosensor for detection of atrazine","volume":"146","author":"Belkhamssa","year":"2016","journal-title":"Talanta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0021-9673(99)01242-X","article-title":"Use of solid-phase extraction and high-performance liquid chromatography for the determination of triazine residues in water: Validation of the method","volume":"869","author":"Pinto","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ultsonch.2004.07.004","article-title":"Determination of pesticides in honey by ultrasonic solvent extraction and thin-layer chromatography","volume":"12","author":"Horvat","year":"2005","journal-title":"Ultrason. Sonochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ab.2006.01.050","article-title":"Determination of atrazine and its metabolites in mouse urine and plasma by LC\u2013MS analysis","volume":"351","author":"Ross","year":"2006","journal-title":"Anal. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11631-011-0536-0","article-title":"Joint toxic effects of heavy metals and atrazine on invasive plant species Solidago Canadensis L.","volume":"30","author":"Han","year":"2011","journal-title":"Chin. J. Geochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.foodchem.2010.11.074","article-title":"Analysis of pesticide residues in sugarcane juice using QuEChERS sample preparation and gas chromatography with electron capture detection","volume":"126","author":"Furlani","year":"2011","journal-title":"Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1002\/jssc.201600883","article-title":"Rapid selective accelerated solvent extraction and simultaneous determination of herbicide atrazine and its metabolites in fruit by ultrahigh performance liquid chromatography","volume":"39","author":"Jia","year":"2016","journal-title":"J. Sep. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"127752","DOI":"10.1016\/j.foodchem.2020.127752","article-title":"Efficient enrichment and analysis of atrazine and its degradation products in Chinese Yam using accelerated solvent extraction and pipette tip solid-phase extraction followed by UPLC\u2013DAD","volume":"337","author":"Wu","year":"2021","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aca.2008.04.037","article-title":"Preparation of new solid phase micro extraction fiber on the basis of atrazine-molecular imprinted polymer: Application for GC and GC\/MS screening of triazine herbicides in water, rice and onion","volume":"616","author":"Djozan","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.microc.2019.01.040","article-title":"Ultrasound-assisted dispersive solid phase extraction based on Fe3O4\/reduced graphene oxide nanocomposites for the determination of 4-tertoctylphenol and atrazine by gas chromatography\u2013mass spectrometry","volume":"146","author":"Er","year":"2019","journal-title":"Microchem. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00604-013-0971-1","article-title":"Rapid extraction and determination of atrazine and its degradation products from microporous mineral sorbents using microwave-assisted solvent extraction followed by ultra-HPLC-MS\/MS","volume":"180","author":"Hu","year":"2013","journal-title":"Mikrochim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111706","DOI":"10.1016\/j.bios.2019.111706","article-title":"Fluorescent hydrogel test kit coordination with smartphone: Robust performance for on-site dimethoate analysis","volume":"145","author":"Kong","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112636","DOI":"10.1016\/j.bios.2020.112636","article-title":"Smart plant-wearable biosensor for in-situ pesticide analysis","volume":"170","author":"Zhao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132208","DOI":"10.1016\/j.foodchem.2022.132208","article-title":"Highly sensitive SERS substrates with multi-hot spots for on-site detection of pesticide residues","volume":"381","author":"Xie","year":"2022","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.snb.2013.10.033","article-title":"A label-free electrochemical immunosensor based on gold nanoparticles for direct detection of atrazine","volume":"191","author":"Liu","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"111441","DOI":"10.1016\/j.bios.2019.111441","article-title":"Electrospun tin (IV) oxide nanofiber based electrochemical sensor for ultrasensitive and selective detection of atrazine in water at trace levels","volume":"141","author":"Supraja","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.talanta.2019.03.114","article-title":"Design of a facile and label-free electrochemical aptasensor for detection of atrazine","volume":"201","author":"Fan","year":"2019","journal-title":"Talanta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13273","DOI":"10.3390\/s140713273","article-title":"The optical property of core-shell nanosensors and detection of atrazine based on localized surface plasmon resonance(LSPR) Sensing","volume":"14","author":"Yang","year":"2014","journal-title":"Sensors"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.snb.2015.04.099","article-title":"SPR quantitative analysis of direct detection of atrazine traces on Au-nanoparticles: Nanoparticles size effect","volume":"218","author":"Liu","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.snb.2016.10.017","article-title":"Development of surface plasmon resonance sensors based on molecularly imprinted nanofilms for sensitive and selective detection of pesticides","volume":"241","author":"Saylan","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.aca.2020.03.045","article-title":"Mesoporous Pd@Pt nanoparticle-linked immunosorbent assay for detection of atrazine","volume":"1116","author":"Kwon","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.talanta.2019.03.108","article-title":"Sensitive surface-enhanced Raman scattering detection of atrazine based on aggregation of silver nanoparticles modified carbon dots Sensitive surface-enhanced Raman scattering detection of aggregation of silver nanoparticles modified carbon dots","volume":"201","author":"Tang","year":"2019","journal-title":"Talanta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.carbpol.2015.10.062","article-title":"Competitive fluorescence assay for specific recognition of atrazine by Magnetic molecularly imprinted polymer based on Fe3O4-chitosan","volume":"137","author":"Liu","year":"2016","journal-title":"Carbohyd Polym."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.snb.2018.02.155","article-title":"Rapid \u201cturn-on\u201d detection of atrazine using highly luminescent N-doped carbon quantum dot","volume":"263","author":"Mohapatra","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Legendre, R., Basinger, N.T., and Iersel, M.W. (2021). Low-Cost Chlorophyll Fluorescence Imaging for Stress Detection. Sensors, 21.","DOI":"10.3390\/s21062055"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.talanta.2008.11.033","article-title":"A fast screening method for the presence of atrazine and other triazines in water using flow injection with chemiluminescent detection","volume":"78","author":"Beale","year":"2009","journal-title":"Talanta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.trac.2008.09.017","article-title":"Immunoanalytical techniques for analyzing pesticides in the environment","volume":"28","author":"Suri","year":"2009","journal-title":"Trends Anal. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14332","DOI":"10.3390\/ijms150814332","article-title":"In vitro selection of a single-stranded DNA molecular recognition element against atrazine","volume":"15","author":"Williams","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/acs.analchem.9b04947","article-title":"Recent Progress in Electrochemiluminescence Sensing and Imaging","volume":"92","author":"Ma","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1021\/ac900756a","article-title":"Development of a new device for ultrasensitive electrochemiluminescence microscopy imaging","volume":"81","author":"Dolci","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.snb.2013.07.057","article-title":"Ultrasensitive electrochemiluminescence immunosensor based on Ru(bpy)32+ and Ag nanoparticles doped SBA-15 for detection of cancer antigen 15-3","volume":"188","author":"Li","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"127367","DOI":"10.1016\/j.snb.2019.127367","article-title":"Ultrasensitive electrochemiluminescence aptasensor for kanamycin detection based on silver nanoparticle-catalyzed chemiluminescent reaction between luminol and hydrogen peroxide","volume":"304","author":"Cheng","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"123794","DOI":"10.1016\/j.jhazmat.2020.123794","article-title":"Novel Au-tetrahedral aptamer nanostructure for the electrochemiluminescence detection of acetamiprid","volume":"401","author":"Guo","year":"2021","journal-title":"J. Hazard. Mater"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1021\/cr068083a","article-title":"Electrogenerated chemiluminescence and its biorelated applications","volume":"108","author":"Miao","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.trac.2014.10.015","article-title":"Amplification strategies using electrochemiluminescence biosensors for the detection of DNA, bioactive molecules and cancer biomarkers","volume":"65","author":"Ding","year":"2015","journal-title":"Trends Anal. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/acs.analchem.6b04675","article-title":"Recent advances in electrochemiluminescence analysis","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bios.2016.09.015","article-title":"An ultrasensitive electrochemiluminescence biosensor for the detection of concanavalin A based on Au nanoparticles-thiosemicarbazide functionalized PtNi nanocubes as signal enhancer","volume":"87","author":"Fan","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bios.2016.03.014","article-title":"A sensitive electro-chemiluminescence immunosensor based on luminophore capped Pd@Au core-shell nanoparticles as signal tracers and ferrocenyl compounds as signal enhancers","volume":"81","author":"Liu","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"128985","DOI":"10.1016\/j.snb.2020.128985","article-title":"An \u201con-off\u201d electrochemiluminescence biosensor based on DNA nanotweezer probe coupled with tripod capture DNA for high sensitive detection of Pb2+","volume":"326","author":"Zhao","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"136644","DOI":"10.1016\/j.electacta.2020.136644","article-title":"A novel electrochemiluminescence aptasensor based CdTe QDs@NH2-MIL-88(Fe) for signal amplification","volume":"354","author":"Chen","year":"2020","journal-title":"Electrochim. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"127364","DOI":"10.1016\/j.snb.2019.127364","article-title":"Electrochemical luminescence sensor based on double suppression for highly sensitive detection of glyphosate","volume":"304","author":"Liu","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113601","DOI":"10.1016\/j.bios.2021.113601","article-title":"A novel electrochemiluminescence aptasensor based on copper-gold bimetallic nanoparticles and its applications","volume":"194","author":"Huang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aca.2019.04.068","article-title":"Bifunctional S, N-Codoped carbon dots-based novel electrochemiluminescent bioassay for ultrasensitive detection of atrazine using activated mesoporous biocarbon as enzyme nanocarriers","volume":"1073","author":"Wu","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111352","DOI":"10.1016\/j.bios.2019.111352","article-title":"Immobilization-free photoelectrochemical aptasensor for environmental pollutants: Design, fabrication and mechanism","volume":"140","author":"Sun","year":"2019","journal-title":"Biosens. Bioelectron."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/9\/3430\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:49Z","timestamp":1760137489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/9\/3430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["s22093430"],"URL":"https:\/\/doi.org\/10.3390\/s22093430","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,30]]}}}