{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:10Z","timestamp":1784012830510,"version":"3.55.0"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alive Charity Foundation through the Research, Innovation and Development Trust (RIDT) of the University of Malta","award":["Hyper4B project"],"award-info":[{"award-number":["Hyper4B project"]}]},{"name":"Alive Charity Foundation through the Research, Innovation and Development Trust (RIDT) of the University of Malta","award":["the Marie Sklodowska-Curie Grant Agreement No. 845645"],"award-info":[{"award-number":["the Marie Sklodowska-Curie Grant Agreement No. 845645"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["Hyper4B project"],"award-info":[{"award-number":["Hyper4B project"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["the Marie Sklodowska-Curie Grant Agreement No. 845645"],"award-info":[{"award-number":["the Marie Sklodowska-Curie Grant Agreement No. 845645"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Electromagnetic thermal therapies for cancer treatment, such as microwave hyperthermia, aim to heat up a targeted tumour site to temperatures within 40 and 44 \u00b0C. Computational simulations used to investigate such heating systems employ the Pennes\u2019 bioheat equation to model the heat exchange within the tissue, which accounts for several tissue properties: density, specific heat capacity, thermal conductivity, metabolic heat generation rate, and blood perfusion rate. We present a review of these thermal and physiological properties relevant for hyperthermia treatments of breast including fibroglandular breast, fatty breast, and breast tumours. The data included in this review were obtained from both experimental measurement studies and estimated properties of human breast tissues. The latter were used in computational studies of breast thermal treatments. The measurement methods, where available, are discussed together with the estimations and approximations considered for values where measurements were unavailable. The review concludes that measurement data for the thermal and physiological properties of breast and tumour tissue are limited. Fibroglandular and fatty breast tissue properties are often approximated from those of generic muscle or fat tissue. Tumour tissue properties are mostly obtained from approximating equations or assumed to be the same as those of glandular tissue. We also present a set of reliable data, which can be used for more accurate modelling and simulation studies to better treat breast cancer using thermal therapies.<\/jats:p>","DOI":"10.3390\/s22103894","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"3894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Review of Thermal and Physiological Properties of Human Breast Tissue"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-2903","authenticated-orcid":false,"given":"Jeantide","family":"Said Camilleri","sequence":"first","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Malta, MSD 2080 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Malta, MSD 2080 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-1117","authenticated-orcid":false,"given":"Sergio","family":"Curto","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-5989","authenticated-orcid":false,"given":"Dario B.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-8037","authenticated-orcid":false,"given":"Laura","family":"Farina","sequence":"additional","affiliation":[{"name":"Translational Medical Device Lab, National University of Ireland Galway, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Caruana Dingli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mater Dei Hospital, MSD 2090 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-7645","authenticated-orcid":false,"given":"Julian","family":"Bonello","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Malta, MSD 2080 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Farhat","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Malta, MSD 2080 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8138-3052","authenticated-orcid":false,"given":"Charles V.","family":"Sammut","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Malta, MSD 2080 Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"ref_1","unstructured":"(2022, March 16). 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