{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:16:53Z","timestamp":1784002613438,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Integrating Perception and Medical Detection Micro-Electromechanical Innovation","award":["0030904151004\/016"],"award-info":[{"award-number":["0030904151004\/016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Flexible pressure sensors with high sensitivity and good linearity are in high demand to meet the long-term and accurate detection requirements for pulse detection. In this study, we propose a composite membrane pressure sensor using polydimethylsiloxane (PDMS) and multiwalled carbon nanotubes (MWNTS) reinforced with isopropanol prepared by solution blending and a self-made 3D-printed mold. The device doped with isopropanol had a higher sensitivity and linearity owning to the construction of additional conductive paths. The optimal conditions for realizing a high-performance pressure sensor are a multiwalled carbon nanotube mass ratio of 7% and a composite membrane thickness of 490 \u03bcm. The membrane achieves a high linear sensitivity of \u221257.07 k\u03a9\u2219kPa\u22121 and a linear fitting correlation coefficient of 98.78% in the 0.13~5.2 kPa pressure range corresponding to pulse detection. Clearly, this device has great potential for application in pulse detection.<\/jats:p>","DOI":"10.3390\/s22134765","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T22:50:23Z","timestamp":1656283823000},"page":"4765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["High-Sensitivity Flexible Piezoresistive Pressure Sensor Using PDMS\/MWNTS Nanocomposite Membrane Reinforced with Isopropanol for Pulse Detection"],"prefix":"10.3390","volume":"22","author":[{"given":"Zhiming","family":"Long","sequence":"first","affiliation":[{"name":"Med + X Center for Manufacturing, West China Hospital of Sichuan University, Chengdu 610041, China"},{"name":"School of Mechanical Engineering, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinggu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Med + X Center for Manufacturing, West China Hospital of Sichuan University, Chengdu 610041, China"},{"name":"School of Mechanical Engineering, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1541\/ieejsmas.138.539","article-title":"Flexible Sensor System for Pulse Detection and Blood Pressure Estimation","volume":"138","author":"Fujita","year":"2018","journal-title":"IEEJ Trans. Sens. Micromach."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1038\/micronano.2016.43","article-title":"Emerging flexible and wearable physical sensing platforms for healthcare and biomedical applications","volume":"2","author":"Kenry","year":"2016","journal-title":"Microsyst. Nanoeng."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eaau6914","DOI":"10.1126\/scirobotics.aau6914","article-title":"A hierarchically patterned, bioinspired e-skin able to detect the direction of applied pressure for robotics","volume":"3","author":"Boutry","year":"2018","journal-title":"Sci. Robot."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1039\/C9TB02531F","article-title":"A review of electronic skin: Soft electronics and sensors for human health","volume":"8","author":"Zhang","year":"2020","journal-title":"J. Mater. Chem. B Mater. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108818","DOI":"10.1016\/j.compositesb.2021.108818","article-title":"Electromechanical sorting method for improving the sensitivity of micropyramid carbon nanotube film flexible force sensor","volume":"217","author":"Yang","year":"2021","journal-title":"Compos. Part B Eng."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109275","DOI":"10.1016\/j.compositesb.2021.109275","article-title":"Highly stretchable and durable fibrous strain sensor with growth ring-like spiral structure for wearable electronics","volume":"225","author":"Kong","year":"2021","journal-title":"Compos. Part B Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108665","DOI":"10.1016\/j.compositesb.2021.108665","article-title":"Highly stretchable and sensitive strain sensor based on polypyrrole coated bacterial cellulose fibrous network for human motion detection","volume":"211","author":"Xu","year":"2021","journal-title":"Compos. Part B Eng."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109243","DOI":"10.1016\/j.compositesb.2021.109243","article-title":"Bamboo-inspired mechanically flexible and electrically conductive polydimethylsiloxane foam materials with designed hierarchical pore structures for ultra-sensitive and reliable piezoresistive pressure sensor","volume":"225","author":"Dai","year":"2021","journal-title":"Compos. Part B Eng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1806388","DOI":"10.1002\/adfm.201806388","article-title":"Flexible Weaving Constructed Self-Powered Pressure Sensor Enabling Continuous Diagnosis of Cardiovascular Disease and Measurement of Cuffless Blood Pressure","volume":"29","author":"Meng","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1109\/JSEN.2014.2368989","article-title":"Flexible Tactile Sensors Using Screen-Printed P(VDF-TrFE) and MWCNT\/PDMS Composites","volume":"15","author":"Khan","year":"2015","journal-title":"IEEE Sens. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"108899","DOI":"10.1016\/j.compositesb.2021.108899","article-title":"Highly stretchable pressure sensors with wrinkled fibrous geometry for selective pressure sensing with minimal lateral strain-induced interference","volume":"217","author":"Yang","year":"2021","journal-title":"Compos. Part. B Eng."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1900367","DOI":"10.1002\/admt.201900367","article-title":"A Highly Sensitive and Cost-Effective Flexible Pressure Sensor with Micropillar Arrays Fabricated by Novel Metal-Assisted Chemical Etching for Wearable Electronics","volume":"4","author":"Zhang","year":"2019","journal-title":"Adv. Mater. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41427-018-0041-6","article-title":"Wearable high-performance pressure sensors based on three-dimensional electrospun conductive nanofibers","volume":"10","author":"Kweon","year":"2018","journal-title":"NPG Asia Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nmat3380","article-title":"A flexible and highly sensitive strain-gauge sensor using reversible interlocking of nanofibres","volume":"11","author":"Pang","year":"2012","journal-title":"Nat. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Khan, S., Lorenzelli, L., and Dahiya, R.S. (July, January 30). Bendable piezoresistive sensors by screen printing MWCNT\/PDMS composites on flexible substrates. Proceedings of the 2014 10th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME), Grenoble, France.","DOI":"10.1109\/PRIME.2014.6872702"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Asano, S., Muroyama, M., Nakayama, T., Hata, Y., Nonomura, Y., and Tanaka, S. (2017). 3-Axis Fully-Integrated Capacitive Tactile Sensor with Flip-Bonded CMOS on LTCC Interposer. Sensors, 17.","DOI":"10.3390\/s17112451"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1021\/nl204052z","article-title":"A Highly Elastic, Capacitive Strain Gauge Based on Percolating Nanotube Networks","volume":"12","author":"Cohen","year":"2012","journal-title":"Nano Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1038\/srep03048","article-title":"Super-stretchable, Transparent Carbon Nanotube-Based Capacitive Strain Sensors for Human Motion Detection","volume":"3","author":"Cai","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108607","DOI":"10.1016\/j.compositesb.2021.108607","article-title":"Fabrication of hierarchically porous structured PDMS composites and their application as a flexible capacitive pressure sensor","volume":"211","author":"Hwang","year":"2021","journal-title":"Compos. Part B Eng."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/adfm.201504755","article-title":"Stretchable, Skin-Mountable, and Wearable Strain Sensors and Their Potential Applications: A Review","volume":"26","author":"Amjadi","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1109\/JSEN.2015.2392084","article-title":"Printed MWCNT-PDMS-Composite Pressure Sensor System for Plantar Pressure Monitoring in Ulcer Prevention","volume":"15","author":"Gerlach","year":"2015","journal-title":"IEEE Sens. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1021\/nl300988z","article-title":"Transparent Triboelectric Nanogenerators and Self-Powered Pressure Sensors Based on Micropatterned Plastic Films","volume":"12","author":"Fan","year":"2012","journal-title":"Nano Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nmat2834","article-title":"Highly sensitive flexible pressure sensors with microstructured rubber dielectric layers","volume":"9","author":"Mannsfeld","year":"2010","journal-title":"Nat. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1038\/ncomms4132","article-title":"A wearable and highly sensitive pressure sensor with ultrathin gold nanowires","volume":"5","author":"Gong","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.carbon.2014.05.022","article-title":"Simple and rapid micropatterning of conductive carbon composites and its application to elastic strain sensors","volume":"77","author":"Kong","year":"2014","journal-title":"Carbon"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1703456","DOI":"10.1002\/adma.201703456","article-title":"Self-Powered Pulse Sensor for Antidiastole of Cardiovascular Disease","volume":"29","author":"Ouyang","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/adma.201404794","article-title":"Eardrum-Inspired Active Sensors for Self-Powered Cardiovascular System Characterization and Throat-Attached Anti-Interference Voice Recognition","volume":"27","author":"Yang","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2001023","DOI":"10.1002\/adhm.202001023","article-title":"Highly Sensitive Flexible Iontronic Pressure Sensor for Fingertip Pulse Monitoring","volume":"9","author":"Lin","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1109\/TBME.2018.2873754","article-title":"A Wearable Multifunctional Pulse Monitor Using Thermosensation-Based Flexible Sensors","volume":"66","author":"Fu","year":"2019","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"075010","DOI":"10.1088\/1361-6579\/aac7ac","article-title":"Comparison of photoplethysmogram measured from wrist and finger and the effect of measurement location on pulse arrival time","volume":"39","author":"Rajala","year":"2018","journal-title":"Physiol. Meas."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/electronics3010043","article-title":"Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems","volume":"3","author":"Williams","year":"2014","journal-title":"Electronics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1109\/TIM.2006.873784","article-title":"Urgent Problems of Metrological Assurance of Optical Pulse Oximetry","volume":"55","author":"Lovinsky","year":"2006","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111345","DOI":"10.1016\/j.msec.2020.111345","article-title":"A CNT-PDMS wearable device for simultaneous measurement of wrist pulse pressure and cardiac electrical activity","volume":"117","author":"Wang","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1800819","DOI":"10.1002\/smll.201800819","article-title":"Multiscale Hierarchical Design of a Flexible Piezoresistive Pressure Sensor with High Sensitivity and Wide Linearity Range","volume":"14","author":"Shi","year":"2018","journal-title":"Small"},{"key":"ref_35","first-page":"384","article-title":"Investigation on the Influence of Solvents on MWCNT-PDMS Nanocomposite Pressure Sensitive Films","volume":"1","author":"Ramalingame","year":"2017","journal-title":"Proceedings"},{"key":"ref_36","unstructured":"Zheng, H., Ramalingame, R., Yahia, K.A., Gerlach, C., and Olfa, K. (2018). Crosstalk Suppression for Piezoresistive Tactile Sensor Arrays with a Large Resistance Measurement Range. Sensors and Measuring Systems, Proceedings of the 19th ITG\/GMA-Symposium, Nuremberg, Germany, 26\u201327 June 2018, VDE."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0924-4247(98)00204-0","article-title":"Measurement errors in the scanning of piezoresistive sensors arrays","volume":"72","year":"1999","journal-title":"Sens. Actuators A Phys."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wu, J., He, S., Li, J., and Song, A. (2016). Cable Crosstalk Suppression with Two-Wire Voltage Feedback Method for Resistive Sensor Array. Sensors, 16.","DOI":"10.3390\/s16020253"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/13\/4765\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:39:09Z","timestamp":1760139549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/13\/4765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":38,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["s22134765"],"URL":"https:\/\/doi.org\/10.3390\/s22134765","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]}}}