{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:44:09Z","timestamp":1760229849283,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regione Piemonte POR-FESR 2014\u20132020: DEFLeCT"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Platelets are emerging as a promising source of blood biomarkers for several pathologies, including cancer. New automated techniques for easier manipulation of platelets in the context of lab-on-a-chips could be of great support for liquid biopsy. Here, several polymeric materials were investigated for their behavior in terms of adhesion and activation of human platelets. Polymeric materials were selected among the most used in microfabrication (PDMS, PMMA and COC) and commercial and home-made resins for 3D printing technology with the aim to identify the most suitable for the realization of microdevices for human platelets isolation and analysis. To visualize adherent platelets and their activation state scanning, electron microscopy was used, while confocal microscopy was used for evaluating platelets\u2019 features. In addition, atomic force microscopy was employed to further study platelets adherent to the polymeric materials. Polymers were divided in two main groups: the most prone to platelet adhesion and materials that cause few or no platelets to adhere. Therefore, different polymeric materials could be identified as suitable for the realization of microdevices aimed at capturing human platelets, while other materials could be employed for the fabrication of microdevices or parts of microdevices for the processing of platelets, without loss on surfaces during the process.<\/jats:p>","DOI":"10.3390\/s22134788","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T22:50:23Z","timestamp":1656283823000},"page":"4788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human Blood Platelets Adsorption on Polymeric Materials for Liquid Biopsy"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-7547","authenticated-orcid":false,"given":"Cristina","family":"Potrich","sequence":"first","affiliation":[{"name":"Fondazione Bruno Kessler, Center for Sensors and Devices, Via Sommarive 18, Povo, 38123 Trento, Italy"},{"name":"Consiglio Nazionale delle Ricerche, Istituto di Biofisica, 38123 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-6038","authenticated-orcid":false,"given":"Francesca","family":"Frascella","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-9398","authenticated-orcid":false,"given":"Valentina","family":"Bertana","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-4261","authenticated-orcid":false,"given":"Mario","family":"Barozzi","sequence":"additional","affiliation":[{"name":"Fondazione Bruno Kessler, Center for Sensors and Devices, Via Sommarive 18, Povo, 38123 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Vanzetti","sequence":"additional","affiliation":[{"name":"Fondazione Bruno Kessler, Center for Sensors and Devices, Via Sommarive 18, Povo, 38123 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Azienda Provinciale per i Servizi Sanitari, S.Chiara Hospital, 38122 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-0565","authenticated-orcid":false,"given":"Attilio Fabio","family":"Cristallo","sequence":"additional","affiliation":[{"name":"Azienda Provinciale per i Servizi Sanitari, S.Chiara Hospital, 38122 Trento, Italy"},{"name":"Servizio Trasfusionale Asl 1 Imperiese, 18100 Imperia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1719-293X","authenticated-orcid":false,"given":"Natalia","family":"Malara","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-9459","authenticated-orcid":false,"given":"Candido Fabrizio","family":"Pirri","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy"},{"name":"Istituto Italiano di Tecnologia (IIT), Via Livorno 60, 10144 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Pederzolli","sequence":"additional","affiliation":[{"name":"Fondazione Bruno Kessler, Center for Sensors and Devices, Via Sommarive 18, Povo, 38123 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Lunelli","sequence":"additional","affiliation":[{"name":"Fondazione Bruno Kessler, Center for Sensors and Devices, Via Sommarive 18, Povo, 38123 Trento, Italy"},{"name":"Consiglio Nazionale delle Ricerche, Istituto di Biofisica, 38123 Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Castro-Giner, F., Gkountela, S., Donato, C., Alborelli, I., Qualgliata, L., Ng, C.K.Y., Piscuoglio, S., and Aceto, N. 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