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In this study, we provide a brief overview of two important technologies used to monitor the local temperatures of individual living cells: fluorescence nano-thermometry and an array of micro-\/nano-sized thin-film thermocouples. We explain some key technical issues that must be addressed and optimised for further practical applications, such as in cell biology, drug selection, and novel antitumor therapy. We also offer a method for combining them into a hybrid measuring system.<\/jats:p>","DOI":"10.3390\/s22145093","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:51:56Z","timestamp":1657180316000},"page":"5093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thermal Probing Techniques for a Single Live Cell"],"prefix":"10.3390","volume":"22","author":[{"given":"Nana","family":"Yang","sequence":"first","affiliation":[{"name":"School of Microelectronics, Shandong University, Jinan 250100, China"},{"name":"School of Electronics, Peking University, Beijing 100871, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-547X","authenticated-orcid":false,"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Shandong University, Jinan 250100, China"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Shandong University, Jinan 250100, China"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Electronics, Peking University, Beijing 100871, China"}]},{"given":"Danhong","family":"Han","sequence":"additional","affiliation":[{"name":"School of Electronics, Peking University, Beijing 100871, China"},{"name":"Beijing Research Institute of Mechanical Equipment, Beijing 100854, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-5980","authenticated-orcid":false,"given":"Shengyong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Electronics, Peking University, Beijing 100871, China"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180055","DOI":"10.1038\/sdata.2018.55","article-title":"Massively parallel recordings in macaque motor cortex during an instructed delayed reach-to-grasp task","volume":"5","author":"Brochier","year":"2018","journal-title":"Sci. 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