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the Ministry of Education; the Ministry of Health and Welfare)","award":["2020R1A6A1A03047902"],"award-info":[{"award-number":["2020R1A6A1A03047902"]}]},{"name":"Korean government (the Ministry of Science and ICT; the Ministry of Education; the Ministry of Health and Welfare)","award":["1711123345"],"award-info":[{"award-number":["1711123345"]}]},{"name":"Korean government (the Ministry of Science and ICT; the Ministry of Education; the Ministry of Health and Welfare)","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}]},{"name":"Korean government (the Ministry of Science and ICT; the Ministry of Education; the Ministry of Health and Welfare)","award":["KMDF_PR_20200901_0008"],"award-info":[{"award-number":["KMDF_PR_20200901_0008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper imaging depths. In preclinical small animal studies, photoacoustic imaging is widely used to visualize biodistribution at the molecular level. Monitoring the whole-body distribution of chromophores in small animals is a key method used in preclinical research, including drug-delivery monitoring, treatment assessment, contrast-enhanced tumor imaging, and gastrointestinal tracking. In this review, photoacoustic systems for the whole-body imaging of small animals are explored and summarized. The configurations of the systems vary with the scanning methods and geometries of the ultrasound transducers. The future direction of research is also discussed with regard to achieving a deeper imaging depth and faster imaging speed, which are the main factors that an imaging system should realize to broaden its application in biomedical studies.<\/jats:p>","DOI":"10.3390\/s22145130","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:06:21Z","timestamp":1657497981000},"page":"5130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies"],"prefix":"10.3390","volume":"22","author":[{"given":"Hyunjun","family":"Kye","sequence":"first","affiliation":[{"name":"Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Korea"}]},{"given":"Yuon","family":"Song","sequence":"additional","affiliation":[{"name":"Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Korea"}]},{"given":"Tsedendamba","family":"Ninjbadgar","sequence":"additional","affiliation":[{"name":"Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-1257","authenticated-orcid":false,"given":"Chulhong","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Convergence IT Engineering, Mechanical Engineering, and Electrical Engineering, School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-0234","authenticated-orcid":false,"given":"Jeesu","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.os-1.11.130","article-title":"The Photophone","volume":"1","author":"Bell","year":"1880","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1364\/OL.404041","article-title":"PAExM: Label-Free Hyper-Resolution Photoacoustic Expansion Microscopy","volume":"45","author":"Kim","year":"2020","journal-title":"Opt. 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