{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:41:03Z","timestamp":1782618063655,"version":"3.54.5"},"reference-count":109,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Midwest Dairy Food Research Center","award":["3006-11026-00098234"],"award-info":[{"award-number":["3006-11026-00098234"]}]},{"name":"Midwest Dairy Food Research Center","award":["2020-67021-31956"],"award-info":[{"award-number":["2020-67021-31956"]}]},{"DOI":"10.13039\/100005825","name":"U.S. Department of Agriculture\u2014National Institute of Food and Agriculture (NIFA)","doi-asserted-by":"publisher","award":["3006-11026-00098234"],"award-info":[{"award-number":["3006-11026-00098234"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"U.S. Department of Agriculture\u2014National Institute of Food and Agriculture (NIFA)","doi-asserted-by":"publisher","award":["2020-67021-31956"],"award-info":[{"award-number":["2020-67021-31956"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Nowadays, the increasing number of foodborne disease outbreaks around the globe has aroused the wide attention of the food industry and regulators. During food production, processing, storage, and transportation, microorganisms may grow and secrete toxins as well as other harmful substances. These kinds of food contamination from microbiological and chemical sources can seriously endanger human health. The traditional detection methods such as cell culture and colony counting cannot meet the requirements of rapid detection due to some intrinsic shortcomings, such as being time-consuming, laborious, and requiring expensive instrumentation or a central laboratory. In the past decade, efforts have been made to develop rapid, sensitive, and easy-to-use detection platforms for on-site food safety regulation. Herein, we review one type of promising biosensing platform that may revolutionize the current food surveillance approaches, the giant magnetoresistance (GMR) biosensors. Benefiting from the advances of nanotechnology, hundreds to thousands of GMR biosensors can be integrated into a fingernail-sized area, allowing the higher throughput screening of food samples at a lower cost. In addition, combined with on-chip microfluidic channels and filtration function, this type of GMR biosensing system can be fully automatic, and less operator training is required. Furthermore, the compact-sized GMR biosensor platforms could be further extended to related food contamination and the field screening of other pathogen targets.<\/jats:p>","DOI":"10.3390\/s22155663","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:43:26Z","timestamp":1659048206000},"page":"5663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Giant Magnetoresistance Biosensors for Food Safety Applications"],"prefix":"10.3390","volume":"22","author":[{"given":"Shuang","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-8391","authenticated-orcid":false,"given":"Phanatchakorn","family":"Sutham","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-6112","authenticated-orcid":false,"given":"Kai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA"},{"name":"Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-8860","authenticated-orcid":false,"given":"Kumar","family":"Mallikarjunan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-6624","authenticated-orcid":false,"given":"Jian-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA"},{"name":"Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4014\/jmb.1310.10013","article-title":"Advances in Rapid Detection Methods for Foodborne Pathogens","volume":"24","author":"Zhao","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/10408398.2015.1126701","article-title":"Advanced molecular diagnostic techniques for detection of food-borne pathogens: Current applications and future challenges","volume":"58","author":"Umesha","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne Illness Acquired in the United States\u2014Major Pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3923\/ajft.2011.87.102","article-title":"Methods for rapid detection of foodborne pathogens: An overview","volume":"6","author":"Mandal","year":"2011","journal-title":"Am. J. Food Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1166\/jbn.2018.2549","article-title":"Advances in screening, detection and enumeration of Escherichia coli using nanotechnology-based methods: A review","volume":"14","author":"Carvalho","year":"2018","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pillai, S.D. (2004). Molecular Methods for Microbial Detection. Preharvest and Postharvest Food Safety, Blackwell Publishing.","DOI":"10.1002\/9780470752579.ch22"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Alahi, M.E.E., and Mukhopadhyay, S.C. (2017). Detection methodologies for pathogen and toxins: A review. Sensors, 17.","DOI":"10.3390\/s17081885"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.food.080708.100730","article-title":"Rapid detection and limitations of molecular techniques","volume":"2","author":"Maurer","year":"2011","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28549-w","article-title":"Preparation of anti-human podoplanin monoclonal antibody and its application in immunohistochemical diagnosis","volume":"8","author":"Xie","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_10","first-page":"770","article-title":"Rapid methods for the detection of foodborne bacterial pathogens: Principles, applications, advantages and limitations","volume":"5","author":"Chan","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, J., Jasim, I., Shen, Z., Zhao, L., Dweik, M., Zhang, S., and Almasri, M. (2019). A microfluidic based biosensor for rapid detection of Salmonella in food products. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216873"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/es505477n","article-title":"Quantitative PCR measurements of Escherichia coli including Shiga Toxin-Producing E. coli (STEC) in Animal Feces and Environmental Waters","volume":"49","author":"Ahmed","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0140-6736(98)01267-7","article-title":"Escherichia coli O157:H7","volume":"352","author":"Mead","year":"1998","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/clinchem\/hvaa307","article-title":"Giant Magnetoresistive Nanosensor Analysis of Circulating Tumor DNA Epidermal Growth Factor Receptor Mutations for Diagnosis and Therapy Response Monitoring","volume":"67","author":"Nesvet","year":"2021","journal-title":"Clin. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bios.2008.07.024","article-title":"Magnetoresistive immunosensor for the detection of Escherichia coli O157:H7 including a microfluidic network","volume":"24","author":"Mujika","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1103\/PhysRevB.39.4828","article-title":"Enhanced magnetoresistance in layered magnetic structures with antiferromagnetic interlayer exchange","volume":"39","author":"Binasch","year":"1989","journal-title":"Phys. Rev. B"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1103\/PhysRevLett.61.2472","article-title":"Giant Magnetoresistance of (001)Fel(001) Cr Magnetic Snperlattices","volume":"61","author":"Baibich","year":"1988","journal-title":"Phys. Rev. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8855","DOI":"10.1021\/acsami.9b20038","article-title":"Electric Field-Tunable Giant Magnetoresistance (GMR) Sensor with Enhanced Linear Range","volume":"12","author":"Wang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TMAG.2019.2935419","article-title":"Unstable Playback Response of CPP-GMR Read Head Induced by Electromagnetic Interference: Structural Dependence","volume":"55","author":"Khunkitti","year":"2019","journal-title":"IEEE Trans. Magn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0956-5663(98)00037-2","article-title":"A biosensor based on magnetoresistance technology","volume":"13","author":"Baselt","year":"1998","journal-title":"Biosens. Bioelectron."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15615","DOI":"10.1038\/s41598-019-52147-z","article-title":"An Automated, Quantitative, and Multiplexed Assay Suitable for Point-of-Care Hepatitis B Virus Diagnostics","volume":"9","author":"Gani","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"153705","DOI":"10.1063\/1.3575591","article-title":"Magnetocardiography with sensors based on giant magnetoresistance","volume":"98","author":"Parkkonen","year":"2011","journal-title":"Appl. Phys. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bios.2018.08.060","article-title":"Multiplex measurement of twelve tumor markers using a GMR multi-biomarker immunoassay biosensor","volume":"123","author":"Gao","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1021\/acssensors.0c01578","article-title":"Magnetoresistive Sensor in Two-Dimension on a 25 \u03bcm Thick Silicon Substrate for in Vivo Neuronal Measurements","volume":"5","author":"Chopin","year":"2020","journal-title":"ACS Sens."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0924-4247(03)00380-7","article-title":"Design and performance of GMR sensors for the detection of magnetic microbeads in biosensors","volume":"107","author":"Rife","year":"2003","journal-title":"Sens. Actuators A Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1063\/1.1544449","article-title":"Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited)","volume":"93","author":"Ferreira","year":"2003","journal-title":"J. Appl. Phys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1116\/1.582476","article-title":"Model for detection of immobilized superparamagnetic nanosphere assay labels using giant magnetoresistive sensors","volume":"18","author":"Tondra","year":"2000","journal-title":"J. Vac. Sci. Technol. A Vac. Surf. Film."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"64512","DOI":"10.1063\/1.2890754","article-title":"Theoretical study of in-plane response of magnetic field sensor to magnetic beads in an in-plane homogeneous field","volume":"103","author":"Damsgaard","year":"2008","journal-title":"J. Appl. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s12161-019-01437-3","article-title":"Aptamer-based detection methodology studies in food safety","volume":"12","author":"Song","year":"2019","journal-title":"Food Anal. Methods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111447","DOI":"10.1016\/j.bios.2019.111447","article-title":"Recent advances of molecularly imprinted polymer-based sensors in the detection of food safety hazard factors","volume":"141","author":"Cao","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bios.2018.01.049","article-title":"Engineering nanomaterials-based biosensors for food safety detection","volume":"106","author":"Lv","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Su, D., Wu, K., Saha, R., Peng, C., and Wang, J.P. (2020). Advances in magnetoresistive biosensors. Micromachines, 11.","DOI":"10.3390\/mi11010034"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"112340","DOI":"10.1016\/j.bios.2020.112340","article-title":"Biomarkers detection with magnetoresistance-based sensors","volume":"165","author":"Ren","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1021\/acsami.1c20141","article-title":"Giant Magnetoresistance Biosensors in Biomedical Applications","volume":"14","author":"Wu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.3389\/fmicb.2018.03280","article-title":"Developments in rapid detection methods for the detection of foodborne campylobacterin the United States","volume":"10","author":"Ricke","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1089\/fpd.2017.2309","article-title":"Developments in Micro- and Nanotechnology for Foodborne Pathogen Detection","volume":"15","author":"Carlson","year":"2018","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bios.2016.01.040","article-title":"Low-fouling surface plasmon resonance biosensor for multi-step detection of foodborne bacterial pathogens in complex food samples","volume":"80","author":"Ermini","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.biotechadv.2009.12.004","article-title":"An overview of foodborne pathogen detection: In the perspective of biosensors","volume":"28","author":"Velusamy","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bios.2006.06.036","article-title":"Pathogen detection: A perspective of traditional methods and biosensors","volume":"22","author":"Lazcka","year":"2007","journal-title":"Biosens. Bioelectron."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1080\/10408398.2013.782483","article-title":"Molecular Detection of Foodborne Pathogens: A Rapid and Accurate Answer to Food Safety","volume":"56","author":"Mangal","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mimet.2011.10.021","article-title":"Multiplex PCR and a chromogenic DNA macroarray for the detection of Listeria monocytogens, Staphylococcus aureus, Streptococcus agalactiae, Enterobacter sakazakii, Escherichia coli O157:H7, Vibrio parahaemolyticus, Salmonella spp. and Pseudomonas fluoresc","volume":"88","author":"Chiang","year":"2012","journal-title":"J. Microbiol. Methods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1745-4565.2012.00386.x","article-title":"Multiplex pcr for the detection of Campylobacter spp. and Salmonella spp. in chicken meat","volume":"32","author":"Alves","year":"2012","journal-title":"J. Food Saf."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-018-1086-5","article-title":"Simultaneous detection of Escherichia coli O157:H7, Staphylococcus aureus and Salmonella by multiplex PCR in milk","volume":"8","author":"Wei","year":"2018","journal-title":"3 Biotech"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.fm.2010.04.008","article-title":"Alternative microbial methods: An overview and selection criteria","volume":"27","author":"Jasson","year":"2010","journal-title":"Food Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mcp.2003.09.007","article-title":"Twelve hour real-time PCR technique for the sensitive and specific detection of Salmonella in raw and ready-to-eat meat products","volume":"18","author":"Ellingson","year":"2004","journal-title":"Mol. Cell. Probes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mimet.2007.04.013","article-title":"A real-time PCR for the detection of Salmonella Enteritidis in poultry meat and consumption eggs","volume":"70","author":"Malorny","year":"2007","journal-title":"J. Microbiol. Methods"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.foodcont.2012.11.044","article-title":"Simultaneous detection of six food-borne pathogens by multiplex PCR with a GeXP analyzer","volume":"32","author":"Zhou","year":"2013","journal-title":"Food Control"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, H., Zhao, Y., Bie, S., Suo, T., Jia, G., Liu, B., Ye, R., and Li, Z. (2019). Development of an electrochemical biosensor for rapid and effective detection of pathogenic Escherichia coli in licorice extract. Appl. Sci., 9.","DOI":"10.3390\/app9020295"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1128\/aem.63.7.2549-2553.1997","article-title":"Use of commercial enzyme immunoassays and immunomagnetic separation systems for detecting Escherichia coli O157 in bovine fecal samples","volume":"63","author":"Chapman","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4315\/0362-028X-72.5.1078","article-title":"Specificity Analysis of a Novel Phage-Derived Ligand in an Enzyme-Linked Fluorescent Assay for the Detection of Escherichia coli O157:H7","volume":"72","author":"Rozand","year":"2009","journal-title":"J. Food Prot."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1099\/00222615-44-6-453","article-title":"Development and evaluation of an ELISA to detect Escherichia coli K88 (F4) fimbrial antibody levels","volume":"44","author":"Garabal","year":"1996","journal-title":"J. Med. Microbiol."},{"key":"ref_52","first-page":"727","article-title":"Direct detection of Escherichia coli, staphylococcus aureus, and Salmonella spp. in animal-derived foods using a magnetic bead-based immunoassay","volume":"38","author":"Kim","year":"2018","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"fyab019","DOI":"10.1093\/fqsafe\/fyab019","article-title":"Quantum dot biosensor combined with antibody and aptamer for tracing food-borne pathogens","volume":"5","author":"Sun","year":"2021","journal-title":"Food Qual. Saf."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1021\/jf063600b","article-title":"A rapid multiplexed chemiluminescent immunoassay for the detection of Escherichia coli O157:H7, Yersinia enterocolitica, Salmonella typhimurium, and Listeria monocytogenes pathogen bacteria","volume":"55","author":"Magliulo","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1021\/acs.jafc.7b05577","article-title":"Molecularly Imprinted Polymer as an Antibody Substitution in Pseudo-immunoassays for Chemical Contaminants in Food and Environmental Samples","volume":"66","author":"Chen","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1039\/c3cs35528d","article-title":"Biosensors: Sense and sensibility","volume":"42","author":"Turner","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chircov, C., B\u00eerc\u0103, A.C., Grumezescu, A.M., and Andronescu, E. (2020). Biosensors-on-Chip: An Up-to-Date Review. Molecules, 25.","DOI":"10.3390\/molecules25246013"},{"key":"ref_58","unstructured":"Mohd Said, N.A. (2014). Electrochemical Biosensor Based on Microfabricated Electrode Arrays for Life Sciences Applications, University College Cork."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3390\/s130201763","article-title":"Recent advances in bacteriophage based biosensors for food-borne pathogen detection","volume":"13","author":"Singh","year":"2013","journal-title":"Sensors"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1080\/00032719.2019.1604726","article-title":"Nanophotonic Device in Combination with Bacteriophages for Enhancing Detection Sensitivity of Escherichia coli in Simulated Wash Water","volume":"52","author":"Tilton","year":"2019","journal-title":"Anal. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ali, A.A., Altemimi, A.B., Alhelfi, N., and Ibrahim, S.A. (2020). Application of biosensors for detection of pathogenic food bacteria: A review. Biosensors, 10.","DOI":"10.3390\/bios10060058"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Vidic, J., Vizzini, P., Manzano, M., Kavanaugh, D., Ramarao, N., Zivkovic, M., Radonic, V., Knezevic, N., Giouroudi, I., and Gadjanski, I. (2019). Point-of-need DNA testing for detection of foodborne pathogenic bacteria. Sensors, 19.","DOI":"10.3390\/s19051100"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/1541-4337.12175","article-title":"Culture-Independent Rapid Detection Methods for Bacterial Pathogens and Toxins in Food Matrices","volume":"15","author":"Wang","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1039\/c3an01789c","article-title":"Recent advances in surface functionalization techniques on polymethacrylate materials for optical biosensor applications","volume":"139","author":"Hosseini","year":"2014","journal-title":"Analyst"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bios.2018.01.023","article-title":"Biosensors for rapid and sensitive detection of Staphylococcus aureus in food","volume":"105","author":"Rubab","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.talanta.2018.03.072","article-title":"Rapid colorimetric lactoferrin-based sandwich immunoassay on cotton swabs for the detection of foodborne pathogenic bacteria","volume":"185","author":"Alamer","year":"2018","journal-title":"Talanta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fm.2018.01.025","article-title":"Nanotechnology: Review of concepts and potential application of sensing platforms in food safety","volume":"75","author":"Krishna","year":"2018","journal-title":"Food Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.biomaterials.2007.01.047","article-title":"SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics","volume":"28","author":"Campbell","year":"2007","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"434015","DOI":"10.1088\/0957-4484\/20\/43\/434015","article-title":"Ultrahigh sensitivity made simple: Nanoplasmonic label-free biosensing with an extremely low limit-of-detection for bacterial and cancer diagnostics","volume":"20","author":"Chen","year":"2009","journal-title":"Nanotechnology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tibtech.2015.09.012","article-title":"Optical Biosensors for the Detection of Pathogenic Microorganisms","volume":"34","author":"Yoo","year":"2016","journal-title":"Trends Biotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0003-2670(01)01399-X","article-title":"Electrochemical nucleic acid biosensors","volume":"469","author":"Wang","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fbioe.2015.00061","article-title":"Review of micro\/nanotechnologies for microbial biosensors","volume":"3","author":"Lim","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bios.2017.03.031","article-title":"A review on various electrochemical techniques for heavy metal ions detection with different sensing platforms","volume":"94","author":"Bansod","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biosystemseng.2007.11.015","article-title":"Sensitivity and specificity performance of a direct-charge transfer biosensor for detecting Bacillus cereus in selected food matrices","volume":"99","author":"Pal","year":"2008","journal-title":"Biosyst. Eng."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00216-012-5738-8","article-title":"Sensitive and rapid amperometric magnetoimmunosensor for the determination of Staphylococcus aureus","volume":"403","author":"Pedrero","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bios.2015.09.030","article-title":"Rapid detection of multiple foodborne pathogens using a nanoparticle-functionalized multi-junction biosensor","volume":"77","author":"Yamada","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.lwt.2019.03.037","article-title":"Rapid detection of Yersinia enterocolitica using a single\u2013walled carbon nanotube-based biosensor for Kimchi product","volume":"108","author":"Sobhan","year":"2019","journal-title":"LWT"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.snb.2017.08.180","article-title":"Gold colloid-nanostructured surfaces for enhanced piezoelectric immunosensing of staphylococcal enterotoxin A","volume":"255","author":"Salmain","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jbiotec.2017.12.011","article-title":"Whole-bacterium SELEX of DNA aptamers for rapid detection of E. coli O157:H7 using a QCM sensor","volume":"266","author":"Yu","year":"2018","journal-title":"J. Biotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11694-007-9021-1","article-title":"QCM immunosensor with nanoparticle amplification for detection of Escherichia coli O157:H7","volume":"1","author":"Liu","year":"2007","journal-title":"Sens. Instrum. Food Qual. Saf."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bios.2011.08.007","article-title":"Piezoelectric immunosensor for direct and rapid detection of staphylococcal enterotoxin A (SEA) at the ng level","volume":"29","author":"Salmain","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.talanta.2019.03.048","article-title":"Rapid and label-free detection of Brucella melitensis in milk and milk products using an aptasensor","volume":"200","author":"Bayramoglu","year":"2019","journal-title":"Talanta"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0304-8853(95)00507-2","article-title":"Spin-dependent scattering and giant magnetoresistance","volume":"151","author":"Butler","year":"1995","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_84","first-page":"699","article-title":"The electrical conductivity of transition metals","volume":"153","author":"Mott","year":"1936","journal-title":"Proc. R. Soc. London. Ser. A Math. Phys. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-8853(98)00266-2","article-title":"Exchange bias","volume":"192","author":"Schuller","year":"1999","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1103\/PhysRevLett.68.3749","article-title":"Giant magnetoresistance in nonmultilayer magnetic systems","volume":"68","author":"Xiao","year":"1992","journal-title":"Phys. Rev. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1103\/PhysRevLett.68.3745","article-title":"Giant magnetoresistance in heterogeneous Cu-Co alloys","volume":"68","author":"Berkowitz","year":"1992","journal-title":"Phys. Rev. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1063\/1.109387","article-title":"Limitations of magnetoresistive sensors based on the giant magnetoresistive effect in granular magnetic composites","volume":"62","author":"Hylton","year":"1993","journal-title":"Appl. Phys. Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fmicb.2016.00400","article-title":"Giant magnetoresistance-based biosensor for detection of influenza A virus","volume":"7","author":"Krishna","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"12227","DOI":"10.1021\/jp0725681","article-title":"Magnetic Particles as Labels in Bioassays:\u2009 Interactions between a Biotinylated Gold Substrate and Streptavidin Magnetic Particles","volume":"111","author":"Liu","year":"2007","journal-title":"J. Phys. Chem. C"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.bios.2010.01.038","article-title":"GMR biosensor arrays: A system perspective","volume":"25","author":"Hall","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1038\/srep11693","article-title":"High performance wash-free magnetic bioassays through microfluidically enhanced particle specificity","volume":"5","author":"Bechstein","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1109\/TMAG.2012.2224327","article-title":"Surface modification for protein and DNA immobilization onto GMR biosensor","volume":"49","author":"Wang","year":"2013","journal-title":"IEEE Trans. Magn."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113982","DOI":"10.1016\/j.bios.2022.113982","article-title":"An automated and mobile magnetoresistive biosensor system for early hepatocellular carcinoma diagnosis","volume":"202","author":"Yao","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2016.04.046","article-title":"Portable, one-step, and rapid GMR biosensor platform with smartphone interface","volume":"85","author":"Choi","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1021\/acssensors.7b00432","article-title":"Portable GMR Handheld Platform for the Detection of Influenza A Virus","volume":"2","author":"Wu","year":"2017","journal-title":"ACS Sens."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"12923","DOI":"10.1021\/acsomega.1c01603","article-title":"Dynamic Range Expansion of the C-Reactive Protein Quantification with a Tandem Giant Magnetoresistance Biosensor","volume":"6","author":"Meng","year":"2021","journal-title":"ACS Omega"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00216-021-03227-5","article-title":"A tandem giant magnetoresistance assay for one-shot quantification of clinically relevant concentrations of N-terminal pro-B-type natriuretic peptide in human blood","volume":"413","author":"Meng","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.snb.2016.04.183","article-title":"Separable detecting of Escherichia coli O157H:H7 by a giant magneto-resistance-based bio-sensing system","volume":"234","author":"Sun","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bios.2008.09.023","article-title":"Rapid DNA multi-analyte immunoassay on a magneto-resistance biosensor","volume":"24","author":"Koets","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.bios.2009.11.028","article-title":"Sensitive giant magnetoresistive-based immunoassay for multiplex mycotoxin detection","volume":"25","author":"Mak","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1021\/ac404015j","article-title":"Magnetic Detection of Mercuric Ion Using Giant Magnetoresistance-Based Biosensing System","volume":"86","author":"Wang","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3389\/fmicb.2019.01077","article-title":"Detection of Influenza a Virus in Swine Nasal Swab Samples With a Wash-Free Magnetic Bioassay and a Handheld Giant Magnetoresistance Sensing System","volume":"10","author":"Su","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bios.2016.02.002","article-title":"Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection","volume":"80","author":"Ng","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/09540105.2012.716026","article-title":"Development of a monoclonal antibody-based ELISA to detect Escherichia coli O157:H7","volume":"24","author":"Feng","year":"2013","journal-title":"Food Agric. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1111\/1541-4337.12656","article-title":"Immunomagnetic separation: An effective pretreatment technology for isolation and enrichment in food microorganisms detection","volume":"19","author":"Wang","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s10238-004-0056-x","article-title":"Rapid detection and differentiation of Gram-negative and Gram-positive pathogenic bacteria in urine using TaqMan probe","volume":"4","author":"Shigemura","year":"2005","journal-title":"Clin. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3389\/fmicb.2019.02530","article-title":"Rapid Calorimetric Detection of Bacterial Contamination: Influence of the Cultivation Technique","volume":"10","author":"Fricke","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Giouroudi, I., and Kokkinis, G. (2017). Recent advances in magnetic microfluidic biosensors. Nanomaterials, 7.","DOI":"10.3390\/nano7070171"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/15\/5663\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:58:30Z","timestamp":1760140710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/15\/5663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":109,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["s22155663"],"URL":"https:\/\/doi.org\/10.3390\/s22155663","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,28]]}}}