{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:27:15Z","timestamp":1763389635047,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Postdoctoral Science Foundation","award":["2022M712460"],"award-info":[{"award-number":["2022M712460"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The development of MEMS acoustic resonators meets the increasing demand for in situ detection with a higher performance and smaller size. In this paper, a lithium niobate film-based S1 mode Lamb wave resonator (HF-LWR) for high-sensitivity gravimetric biosensing is proposed. The fabricated resonators, based on a 400-nm X-cut lithium niobate film, showed a resonance frequency over 8 GHz. Moreover, a PMMA layer was used as the mass-sensing layer, to study the performance of the biosensors based on HF-LWRs. Through optimizing the thickness of the lithium niobate film and the electrode configuration, the mass sensitivity of the biosensor could reach up to 74,000 Hz\/(ng\/cm2), and the maximum value of figure of merit (FOM) was 5.52 \u00d7 107, which shows great potential for pushing the performance boundaries of gravimetric-sensitive acoustic biosensors.<\/jats:p>","DOI":"10.3390\/s22155912","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:16:55Z","timestamp":1660018615000},"page":"5912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A High-Sensitivity Gravimetric Biosensor Based on S1 Mode Lamb Wave Resonator"],"prefix":"10.3390","volume":"22","author":[{"given":"Tiancheng","family":"Luo","sequence":"first","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-4570","authenticated-orcid":false,"given":"Wenjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"},{"name":"Hubei Yangtze Memory Laboratories, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Wen","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tong","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-5745","authenticated-orcid":false,"given":"Yao","family":"Cai","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"},{"name":"Hubei Yangtze Memory Laboratories, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6251-7123","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-2674","authenticated-orcid":false,"given":"Chengliang","family":"Sun","sequence":"additional","affiliation":[{"name":"The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China"},{"name":"Hubei Yangtze Memory Laboratories, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vigneshvar, S., Sudhakumari, C., Senthilkumaran, B., and Prakash, H. 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