{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:17:17Z","timestamp":1782814637820,"version":"3.54.5"},"reference-count":37,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["118S074"],"award-info":[{"award-number":["118S074"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["CA17115"],"award-info":[{"award-number":["CA17115"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"COST Action","doi-asserted-by":"publisher","award":["118S074"],"award-info":[{"award-number":["118S074"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"COST Action","doi-asserted-by":"publisher","award":["CA17115"],"award-info":[{"award-number":["CA17115"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Microwave hyperthermia (MH) requires the effective calibration of antenna excitations for the selective focusing of the microwave energy on the target region, with a nominal effect on the surrounding tissue. To this end, many different antenna calibration methods, such as optimization techniques and look-up tables, have been proposed in the literature. These optimization procedures, however, do not consider the whole nature of the electric field, which is a complex vector field; instead, it is simplified to a real and scalar field component. Furthermore, most of the approaches in the literature are system-specific, limiting the applicability of the proposed methods to specific configurations. In this paper, we propose an antenna excitation optimization scheme applicable to a variety of configurations and present the results of a convolutional neural network (CNN)-based approach for two different configurations. The data set for CNN training is collected by superposing the information obtained from individual antenna elements. The results of the CNN models outperform the look-up table results. The proposed approach is promising, as the phase-only optimization and phase\u2013power-combined optimization show a 27% and 4% lower hotspot-to-target energy ratio, respectively, than the look-up table results for the linear MH applicator. The proposed deep-learning-based optimization technique can be utilized as a protocol to be applied on any MH applicator for the optimization of the antenna excitations, as well as for a comparison of MH applicators.<\/jats:p>","DOI":"10.3390\/s22176343","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T02:55:34Z","timestamp":1661309734000},"page":"6343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antenna Excitation Optimization with Deep Learning for Microwave Breast Cancer Hyperthermia"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0458","authenticated-orcid":false,"given":"Gulsah","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halimcan","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Enes","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Demirel","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-5799","authenticated-orcid":false,"given":"Mehmet Nuri","family":"Akinci","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-2945","authenticated-orcid":false,"given":"Tuba","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"},{"name":"Mitos Medical Technologies, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5769-6032","authenticated-orcid":false,"given":"Ibrahim","family":"Akduman","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul 34469, Turkey"},{"name":"Mitos Medical Technologies, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2020.03.004","article-title":"Recent Technological Advancements In Radiofrequency- and Microwave-Mediated Hyperthermia For Enhancing Drug Delivery","volume":"163\u2013164","author":"Paulides","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Androulakis, I., Mestrom, R.M.C., Christianen, M.E.M.C., Kolkman-Deurloo, I.-K.K., and van Rhoon, G.C. (2022). Simultaneous ThermoBrachytherapy: Electromagnetic Simulation Methods for Fast and Accurate Adaptive Treatment Planning. Sensors, 22.","DOI":"10.20944\/preprints202201.0401.v1"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sumser, K., Bellizzi, G.G., van Rhoon, G.C., and Paulides, M.M. (2020). The Potential of Adjusting Water Bolus Liquid Properties for Economic and Precise MR Thermometry Guided Radiofrequency Hyperthermia. Sensors, 20.","DOI":"10.3390\/s20102946"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.ctrv.2015.05.009","article-title":"Local Hyperthermia Combined With Radiotherapy And-\/Or Chemotherapy: Recent Advances And Promises For The Future","volume":"41","author":"Datta","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ferrero, R., Androulakis, I., Martino, L., Nadar, R., van Rhoon, G.C., and Manzin, A. (2022). Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia. Sensors, 22.","DOI":"10.3390\/s22103610"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Altintas, G., Akduman, I., Janjic, A., and Yilmaz, T. (2021). A Novel Approach on Microwave Hyperthermia. Diagnostics, 11.","DOI":"10.3390\/diagnostics11030493"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/026567399285846","article-title":"An adaptive microwave phased array for targeted heating of deep tumours in intact breast: Animal study results","volume":"15","author":"Fenn","year":"1999","journal-title":"Int. J. Hyperth."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1109\/TAP.2011.2165492","article-title":"Optimal Polarization Synthesis of Arbitrary Arrays With Focused Power Pattern","volume":"59","author":"Fuchs","year":"2011","journal-title":"IEEE Trans. Antennas Propag."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kosmas, P., Zastrow, E., Hagness, S.C., and Van Veen, B.D. (2007, January 26\u201329). A Computational Study of Time Reversal Techniques for Ultra-Wideband Microwave Hyperthermia Treatment of Breast Cancer. Proceedings of the IEEE Statistical Signal Processing Workshop, Madison, WI, USA.","DOI":"10.1109\/SSP.2007.4301270"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1109\/TBME.2010.2103943","article-title":"Time-Multiplexed Beamforming For Noninvasive Microwave Hyperthermia Treatment","volume":"58","author":"Zastrow","year":"2011","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1109\/TBME.2012.2199492","article-title":"A Preclinical System Prototype For Focused Microwave Thermal Therapy of The Breast","volume":"59","author":"Stang","year":"2012","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_12","unstructured":"Trefna, H., Togni, P., Shiee, R., and Persson, M. (2010, January 12\u201316). Time-reversal system for microwave hyperthermia. Proceedings of the 4th EuCAP, Barcelona, Spain."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1109\/LGRS.2005.846835","article-title":"Frequency Dispersion Compensation In Time Reversal Techniques For UWB Electromagnetic Waves","volume":"2","author":"Yavuz","year":"2005","journal-title":"IEEE Geosci. Remote Sens. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2528\/PIER10011207","article-title":"Optimal Constrained Field Focusing for Hyperthermia Cancer Therapy: A Feasibility Assessment on Realistic Phantoms","volume":"102","author":"Iero","year":"2010","journal-title":"Prog. Electromagn. Res."},{"key":"ref_15","unstructured":"Isernia, T., and Panariallo, G. (October, January 28). Optimal focusing of scalar fields with arbitrary upper bounds. Proceedings of the Atti XI Riunione Nazionale di Elettromagnetismo (Italian), (XI RiNEm), Florence, Italy."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"093702","DOI":"10.1063\/1.4817998","article-title":"Focusing Time Harmonic Scalar Fields In Non-Homogenous Lossy Media: Inverse Filter vs. Constrained Power Focusing Optimization","volume":"103","author":"Iero","year":"2013","journal-title":"Appl. Phys. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1109\/LAWP.2013.2275202","article-title":"Focusing Time-Harmonic Scalar Fields In Complex Scenarios: A Comparison","volume":"12","author":"Iero","year":"2013","journal-title":"IEEE Antennas Wirel. Propag. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1080\/09205071.2015.1059292","article-title":"Constrained Power Focusing Of Vector Fields: An Innovative Globally Optimal Strategy","volume":"29","author":"Iero","year":"2015","journal-title":"J. Electromagn. Waves Appl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1109\/TAP.2015.2463681","article-title":"Microwave Hyperthermia For Breast Cancer Treatment Using Electromagnetic And Thermal Focusing Tested On Realistic Breast Models And Antenna Arrays","volume":"63","author":"Nguyen","year":"2015","journal-title":"IEEE Trans. Antennas Propag."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1109\/TBME.2016.2602233","article-title":"Three-Dimensional Microwave Hyperthermia For Breast Cancer Treatment in A Realistic Environment Using Particle Swarm Optimization","volume":"64","author":"Nguyen","year":"2017","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1109\/TAP.2017.2700164","article-title":"3-D Focused Microwave Hyperthermia For Breast Cancer Treatment With Experimental Validation","volume":"65","author":"Nguyen","year":"2017","journal-title":"IEEE Trans. Antennas Propag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1109\/TMI.2016.2521800","article-title":"A CNN Regression Approach For Real-Time 2D\/3D Registration","volume":"35","author":"Miao","year":"2016","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Oliveira, B.L., Godinho, D., O\u2019Halloran, M., Glavin, M., Jones, E., and Concei\u00e7\u00e3o, R.C. (2018). Diagnosing Breast Cancer with Microwave Technology: Remaining Challenges and Potential Solutions with Machine Learning. Diagnostics, 8.","DOI":"10.3390\/diagnostics8020036"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kim, Y., Audigier, C., Ellens, N., and Boctor, E.M. (2018, January 22\u201325). Low-Cost Ultrasound Thermometry for HIFU Therapy Using CNN. Proceedings of the 2018 IEEE International Ultrasonics Symposium (IUS), Kobe, Japan.","DOI":"10.1109\/ULTSYM.2018.8579982"},{"key":"ref_25","unstructured":"Yilmaz, T., Akinci, M.N., Girgin, E., and \u00d6nal, H. A Real-time Breast Hyperthermia Monitoring Scheme Based on Processing of Microwave Scattering Parameters with Deep Learning, TechRxiv, submitted."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"226059","DOI":"10.1109\/ACCESS.2020.3045464","article-title":"A Deep Learning-Based Approach For Radiation Pattern Synthesis Of An Array Antenna","volume":"8","author":"Kim","year":"2020","journal-title":"IEEE Access"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1109\/TWC.2019.2956146","article-title":"Joint Antenna Selection And Hybrid Beamformer Design Using Unquantized and Quantized Deep Learning Networks","volume":"19","author":"Elbir","year":"2020","journal-title":"IEEE Trans. Wirel. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1017\/S1759078721001070","article-title":"Convolutional Neural Network For 2D Adaptive Beamforming of Phased Array Antennas With Robustness To Array Imperfections","volume":"13","author":"Sallam","year":"2021","journal-title":"Int. J. Microw. Wirel. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/jappl.1998.85.1.5","article-title":"Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm","volume":"85","author":"Pennes","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1109\/TAP.2013.2293336","article-title":"Thermal And Microwave Constrained Focusing For Patient-Specific Breast Cancer Hyperthermia: A Robustness Assessment","volume":"62","author":"Iero","year":"2014","journal-title":"IEEE Trans. Antennas Propag."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/02656730903110539","article-title":"A Literature Survey On Indicators For Characterisation And Optimisation Of SAR Distributions In Deep Hyperthermia, A Plea For Standardisation","volume":"25","author":"Canters","year":"2009","journal-title":"Int. J. Hyperth."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1109\/TBME.2008.2002130","article-title":"Development Of Anatomically Realistic Numerical Breast Phantoms With Accurate Dielectric Properties For Modeling Microwave Interactions With The Human Breast","volume":"55","author":"Zastrow","year":"2008","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_33","unstructured":"(2020, November 10). UWCEM-Phantom Repository. Available online: https:\/\/uwcem.ece.wisc.edu\/phantomRepository.html."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1088\/0031-9155\/52\/20\/002","article-title":"A Large-Scale Study of The Ultrawideband Microwave Dielectric Properties Of Normal, Benign And Malignant Breast Tissues Obtained From Cancer Surgeries","volume":"52","author":"Lazebnik","year":"2007","journal-title":"Phys. Med. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Baskaran, D., and Arunachalam, K. (2019, January 13\u201315). Optimization techniques for hyperthermia treatment planning of breast cancer: A comparative study. Proceedings of the IEEE MTT-S International Microwave and RF Conference (IMARC), Mumbai, India.","DOI":"10.1109\/IMaRC45935.2019.9118678"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1109\/TBME.2016.2627941","article-title":"Differential Evolution Optimization of the SAR Distribution for Head and Neck Hyperthermia","volume":"64","author":"Cappiello","year":"2017","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/02656736.2017.1337935","article-title":"Design and characterisation of a phased antenna array for intact breast hyperthermia","volume":"34","author":"Curto","year":"2018","journal-title":"Int. J. Hyperth."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/17\/6343\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:14:11Z","timestamp":1760141651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/17\/6343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":37,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["s22176343"],"URL":"https:\/\/doi.org\/10.3390\/s22176343","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]}}}