{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:09:37Z","timestamp":1760551777223,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"National Natural Science Foundation of China","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"Science Foundation of Jiangxi Province","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"Department of Education of Jiangxi Province","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"Jiangxi Science &amp; Technology Normal University","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]},{"name":"State Key Laboratory of Molecular Engineering of Polymers","award":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"],"award-info":[{"award-number":["2021YFE0201400","51773041","61890940","22066011","XDB30000000","20192BBHL80017","GJJ211105","2021QNBJRC002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Field-effect transistor (FET) sensors require not only high sensitivity but also excellent regeneration ability before widespread applications are possible. Although some regenerative FETs have been reported, their lowest limit of detection (LoD) barely achieves 10\u221215 mol L\u22121. Here, we develop a graphene FET with a regenerative sensing interface based on dynamic covalent chemistry (DCvC). The LoD down to 5.0 \u00d7 10\u221220 mol L\u22121 remains even after 10 regenerative cycles, around 4\u20135 orders of magnitude lower than existing transistor sensors. Owing to its ultra-sensitivity, regeneration ability, and advantages such as simplicity, low cost, label-free and real-time response, the FET sensor based on DCvC is valuable in applications such as medical diagnosis, environment monitoring, etc.<\/jats:p>","DOI":"10.3390\/s22186947","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T23:16:36Z","timestamp":1663197396000},"page":"6947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasensitive and Regenerative Transistor Sensor Based on Dynamic Covalent Chemistry"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-7306","authenticated-orcid":false,"given":"Ban-Peng","family":"Cao","sequence":"first","affiliation":[{"name":"Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China"},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-077X","authenticated-orcid":false,"given":"Changhao","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-0460","authenticated-orcid":false,"given":"Xuejun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-7778","authenticated-orcid":false,"given":"Qiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dacheng","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1002\/smll.201400463","article-title":"Graphene Field-effect Transistor and Its Application for Electronic Sensing","volume":"10","author":"Zhan","year":"2014","journal-title":"Small"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10319","DOI":"10.1021\/acs.chemrev.1c00924","article-title":"Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization","volume":"122","author":"Dai","year":"2022","journal-title":"Chem. 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