{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:18:49Z","timestamp":1773346729508,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Israel Innovation Authority","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}]},{"name":"Israel Innovation Authority","award":["R01AG056352"],"award-info":[{"award-number":["R01AG056352"]}]},{"name":"Israel Innovation Authority","award":["820820"],"award-info":[{"award-number":["820820"]}]},{"name":"NIH","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}]},{"name":"NIH","award":["R01AG056352"],"award-info":[{"award-number":["R01AG056352"]}]},{"name":"NIH","award":["820820"],"award-info":[{"award-number":["820820"]}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative 2 Joint Undertaking","doi-asserted-by":"publisher","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative 2 Joint Undertaking","doi-asserted-by":"publisher","award":["R01AG056352"],"award-info":[{"award-number":["R01AG056352"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative 2 Joint Undertaking","doi-asserted-by":"publisher","award":["820820"],"award-info":[{"award-number":["820820"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tel Aviv University Center for AI and Data Science (TAD)","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}]},{"name":"Tel Aviv University Center for AI and Data Science (TAD)","award":["R01AG056352"],"award-info":[{"award-number":["R01AG056352"]}]},{"name":"Tel Aviv University Center for AI and Data Science (TAD)","award":["820820"],"award-info":[{"award-number":["820820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Remote assessment of the gait of older adults (OAs) during daily living using wrist-worn sensors has the potential to augment clinical care and mobility research. However, hand movements can degrade gait detection from wrist-sensor recordings. To address this challenge, we developed an anomaly detection algorithm and compared its performance to four previously published gait detection algorithms. Multiday accelerometer recordings from a wrist-worn and lower-back sensor (i.e., the \u201cgold-standard\u201d reference) were obtained in 30 OAs, 60% with Parkinson\u2019s disease (PD). The area under the receiver operator curve (AUC) and the area under the precision\u2013recall curve (AUPRC) were used to evaluate the performance of the algorithms. The anomaly detection algorithm obtained AUCs of 0.80 and 0.74 for OAs and PD, respectively, but AUPRCs of 0.23 and 0.31 for OAs and PD, respectively. The best performing detection algorithm, a deep convolutional neural network (DCNN), exhibited high AUCs (i.e., 0.94 for OAs and 0.89 for PD) but lower AUPRCs (i.e., 0.66 for OAs and 0.60 for PD), indicating trade-offs between precision and recall. When choosing a classification threshold of 0.9 (i.e., opting for high precision) for the DCNN algorithm, strong correlations (r &gt; 0.8) were observed between daily living walking time estimates based on the lower-back (reference) sensor and the wrist sensor. Further, gait quality measures were significantly different in OAs and PD compared to healthy adults. These results demonstrate that daily living gait can be quantified using a wrist-worn sensor.<\/jats:p>","DOI":"10.3390\/s22187094","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T04:28:55Z","timestamp":1663648135000},"page":"7094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Gait Detection from a Wrist-Worn Sensor Using Machine Learning Methods: A Daily Living Study in Older Adults and People with Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-0699","authenticated-orcid":false,"given":"Yonatan E.","family":"Brand","sequence":"first","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6492416, Israel"},{"name":"Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel"}]},{"given":"Dafna","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6492416, Israel"},{"name":"Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel"}]},{"given":"Eran","family":"Gazit","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6492416, Israel"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2742","authenticated-orcid":false,"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-8307","authenticated-orcid":false,"given":"Ran","family":"Gilad-Bachrach","sequence":"additional","affiliation":[{"name":"Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Edmond J. Safra Center for Bioinformatics, Tel-Aviv University, Tel Aviv 6997801, Israel"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-0776","authenticated-orcid":false,"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6492416, Israel"},{"name":"Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Rush Alzheimer\u2019s Disease Center and Department of Orthopedic Surgery, Rush University, Chicago, IL 60612, USA"},{"name":"Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1001\/archinternmed.2011.1477","article-title":"Total Daily Physical Activity and Longevity in Old Age","volume":"172","author":"Buchman","year":"2012","journal-title":"Arch. 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