{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:12:17Z","timestamp":1760231537432,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, we explored the potential of applying biosensors based on silicon nanowire field-effect transistors (bio\u2013NWFETs) as molecular absorption sensors. Using quercetin and Copper (Cu2+) ion as an example, we demonstrated the use of an opto\u2013FET approach for the detection of molecular interactions. We found that photons with wavelengths of 450 nm were absorbed by the molecular complex, with the absorbance level depending on the Cu2+ concentration. Quantitative detection of the molecular absorption of metal complexes was performed for Cu2+ concentrations ranging between 0.1 \u03bcM and 100 \u03bcM, in which the photon response increased linearly with the copper concentration under optimized bias parameters. Our opto\u2013FET approach showed an improved absorbance compared with that of a commercial ultraviolet-visible spectrophotometry.<\/jats:p>","DOI":"10.3390\/s22197219","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T03:34:17Z","timestamp":1664163257000},"page":"7219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opto Field-Effect Transistors for Detecting Quercetin\u2013Cu2+ Complex"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-8299","authenticated-orcid":false,"given":"Pradhana Jati Budhi","family":"Laksana","sequence":"first","affiliation":[{"name":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan"},{"name":"Nano Science and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan"},{"name":"Institute of Physics, Academia Sinica, Taipei 11529, Taiwan"}]},{"given":"Li-Chu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan"}]},{"given":"Chang-Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan"}]},{"given":"Kuei-Shu","family":"Chang-Liao","sequence":"additional","affiliation":[{"name":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan"}]},{"given":"Mathew K.","family":"Moodley","sequence":"additional","affiliation":[{"name":"Discipline of Physics, School of Chemistry and Physics, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Durban 4000, South Africa"}]},{"given":"Chii-Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Physics, Academia Sinica, Taipei 11529, Taiwan"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization, International Atomic Energy Association, and Food and Agriculture Organization (FAO) (1996). 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