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Twenty healthy volunteers were recruited and underwent whole-knee MRI using qUTE-Cones sequences. The k-space data were retrospectively undersampled with different undersampling rates. The undersampled qUTE-Cones data were reconstructed using both zero-filling and CS reconstruction. Using CS-reconstructed UTE images, various parameters were estimated in 10 different regions of interests (ROIs) in tendons, ligaments, menisci, and cartilage. Structural similarity, percentage error, and Pearson\u2019s correlation were calculated to assess the performance. Dramatically reduced streaking artifacts and improved SSIM were observed in UTE images from CS reconstruction. A mean SSIM of ~0.90 was achieved for all CS-reconstructed images. Percentage errors between fully sampled and undersampled CS-reconstructed images were below 5% for up to 50% undersampling (i.e., 2\u00d7 acceleration). High linear correlation was observed (&gt;0.95) for all qUTE parameters estimated in all subjects. CS-based reconstruction combined with efficient Cones trajectory is expected to achieve a clinically feasible scan time for qUTE imaging.<\/jats:p>","DOI":"10.3390\/s22197459","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T03:07:28Z","timestamp":1665371248000},"page":"7459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Accelerated Quantitative 3D UTE-Cones Imaging Using Compressed Sensing"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-1052","authenticated-orcid":false,"given":"Jiyo S.","family":"Athertya","sequence":"first","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-7767","authenticated-orcid":false,"given":"Amir","family":"Masoud Afsahi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-1779","authenticated-orcid":false,"given":"Alecio F.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Moazamian","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Jerban","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungseok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego, CA 92103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.radi.2004.07.007","article-title":"MR imaging with ultrashort TE (UTE) pulse sequences: Basic principles","volume":"11","author":"Holmes","year":"2005","journal-title":"Radiography"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1002\/mrm.26928","article-title":"Rapid Compressed Sensing Reconstruction of 3D Non-Cartesian MRI","volume":"79","author":"Baron","year":"2018","journal-title":"MRM"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jmri.20851","article-title":"Magnetic resonance imaging with ultrashort TE (UTE) PULSE sequences: Technical considerations","volume":"25","author":"Tyler","year":"2007","journal-title":"J. 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