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Typical signals include bioelectrical signals, biophysical signals, and biochemical signals, which have applications in the fields of athletic training, medical diagnosis and prevention, and rehabilitation. In particular, since the COVID-19 pandemic, there has been a dramatic increase in real-time interest in personal health. This has created an urgent need for flexible, wearable, portable, and real-time monitoring sensors to remotely monitor these signals in response to health management. To this end, the paper reviews recent advances in flexible wearable sensors for monitoring vital signals in sports and health. More precisely, emerging wearable devices and systems for health and exercise-related vital signals (e.g., ECG, EEG, EMG, inertia, body movements, heart rate, blood, sweat, and interstitial fluid) are reviewed first. Then, the paper creatively presents multidimensional and multimodal wearable sensors and systems. The paper also summarizes the current challenges and limitations and future directions of wearable sensors for vital typical signal detection. Through the review, the paper finds that these signals can be effectively monitored and used for health management (e.g., disease prediction) thanks to advanced manufacturing, flexible electronics, IoT, and artificial intelligence algorithms; however, wearable sensors and systems with multidimensional and multimodal are more compliant.<\/jats:p>","DOI":"10.3390\/s22207784","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T01:44:13Z","timestamp":1665711853000},"page":"7784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["A Review of Recent Advances in Vital Signals Monitoring of Sports and Health via Flexible Wearable Sensors"],"prefix":"10.3390","volume":"22","author":[{"given":"Wenbin","family":"Sun","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-1715","authenticated-orcid":false,"given":"Weixia","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jaber, M.M., Alameri, T., Ali, M.H., Alsyouf, A., Al-Bsheish, M., Aldhmadi, B.K., Ali, S.Y., Abd, S.K., Ali, S.M., and Albaker, W. 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