{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:34:18Z","timestamp":1781282058073,"version":"3.54.1"},"reference-count":91,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sapienza International Doctoral Fellow Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Medical images play an important role in medical diagnosis and treatment. Oncologists analyze images to determine the different characteristics of deadly diseases, plan the therapy, and observe the evolution of the disease. The objective of this paper is to propose a method for the detection of brain tumors. Brain tumors are identified from Magnetic Resonance (MR) images by performing suitable segmentation procedures. The latest technical literature concerning radiographic images of the brain shows that deep learning methods can be implemented to extract specific features of brain tumors, aiding clinical diagnosis. For this reason, most data scientists and AI researchers work on Machine Learning methods for designing automatic screening procedures. Indeed, an automated method would result in quicker segmentation findings, providing a robust output with respect to possible differences in data sources, mostly due to different procedures in data recording and storing, resulting in a more consistent identification of brain tumors. To improve the performance of the segmentation procedure, new architectures are proposed and tested in this paper. We propose deep neural networks for the detection of brain tumors, trained on the MRI scans of patients\u2019 brains. The proposed architectures are based on convolutional neural networks and inception modules for brain tumor segmentation. A comparison of these proposed architectures with the baseline reference ones shows very interesting results. MI-Unet showed a performance increase in comparison to baseline Unet architecture by 7.5% in dice score, 23.91% insensitivity, and 7.09% in specificity. Depth-wise separable MI-Unet showed a performance increase by 10.83% in dice score, 2.97% in sensitivity, and 12.72% in specificity as compared to the baseline Unet architecture. Hybrid Unet architecture achieved performance improvement of 9.71% in dice score, 3.56% in sensitivity, and 12.6% in specificity. Whereas the depth-wise separable hybrid Unet architecture outperformed the baseline architecture by 15.45% in dice score, 20.56% in sensitivity, and 12.22% in specificity.<\/jats:p>","DOI":"10.3390\/s22218201","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"8201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Deep Learning Hybrid Techniques for Brain Tumor Segmentation"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-5707","authenticated-orcid":false,"given":"Khushboo","family":"Munir","sequence":"first","affiliation":[{"name":"Department of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Via Eudossiana 18, 00184 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-7617","authenticated-orcid":false,"given":"Fabrizio","family":"Frezza","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Via Eudossiana 18, 00184 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-0015","authenticated-orcid":false,"given":"Antonello","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Via Eudossiana 18, 00184 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ciregan, D., Meier, U., and Schmidhuber, J. 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