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to extend and complement this more conventional measure. We aimed to measure the eye movement of a case series of MS patients with relapsing\u2013remitting MS to assess their cognitive status using a conventional gaze tracker. A total of 41 relapsing\u2013remitting MS patients and 43 age-matched healthy controls were recruited for this study. Overall, we could not find a clear common pattern in the eye motor abnormalities. Vertical eye movement was more impaired in MS patients than horizontal movement. Increased latencies were found in the prosaccades and reflexive saccades of antisaccade tests. The smooth pursuit was impaired with more corrections (backup and catchup movements, p&lt;0.01). No correlation was found between eye movement variables and EDSS or disease duration. Despite significant alterations in the behavior of the eye movements in MS patients, which are compatible with altered cognitive status, there is no common pattern of these alterations. We interpret this as a consequence of the patchy, heterogeneous distribution of white matter involvement in MS that provokes multiple combinations of impairment at different points in the different networks involved in eye motor control. Further studies are therefore required.<\/jats:p>","DOI":"10.3390\/s22218220","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"8220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Toward an Automatic Assessment of Cognitive Dysfunction in Relapsing\u2013Remitting Multiple Sclerosis Patients Using Eye Movement Analysis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-0564","authenticated-orcid":false,"given":"Cecilia E.","family":"Garc\u00eda Cena","sequence":"first","affiliation":[{"name":"Escuela T\u00e9cnica Superior de Ingenier\u00eda y Dise\u00f1o Industrial, Centre for Automation and Robotics, ETSIDI-CAR, Universidad Polit\u00e9cnica de Madrid, 28012 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-7791","authenticated-orcid":false,"given":"David","family":"G\u00f3mez-Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Child Neurology Unit, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Research Institute (VHIR), Euro-NMD and ERN-RND, 08035 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-2458","authenticated-orcid":false,"given":"Irene","family":"Pulido-Valdeolivas","sequence":"additional","affiliation":[{"name":"Anatomy, Histology and Neuroscience Department, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}]},{"given":"Victoria Gal\u00e1n","family":"S\u00e1nchez-Seco","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cVirgen de la Salud\u201d, 45004 Toledo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-3034","authenticated-orcid":false,"given":"Angela","family":"Domingo-Santos","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u201cLa Mancha Centro\u201d General Hospital, Alc\u00e1zar de San Juan, 13600 Ciudad Real, Spain"}]},{"given":"Sara","family":"Moreno-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre\u201d, 28041 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4809","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre\u201d, 28041 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain"},{"name":"Department of Medicine, Complutense University, 28040 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/09638280310001608591","article-title":"A review about the impact of multiple sclerosis on health-related quality of life","volume":"25","author":"Morales","year":"2003","journal-title":"Disabil. 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