{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:15:49Z","timestamp":1776150949293,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ENI-CBC-MED Programme 2014\u20132020\u2014TRANSDAIRY Project","award":["24\/1640"],"award-info":[{"award-number":["24\/1640"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>An innovative optical-chemical sensor has been used to detect the 2-furaldehyde (2-FAL) in milk. The proposed sensing approach exploits the refractive index changing in a microstructured chip based on a plastic optical fiber (POF) with orthogonal micro-holes containing a specific molecularly imprinted polymer (MIP). This POF-MIP chemical chip modifies the surface plasmon resonance (SPR) phenomena excited in another sensor chip realized in POFs (SPR-POF) and connected in series. The proposed sensor configuration exploits MIP receptors avoiding any modification of the gold film of the SPR platform. This work reports the performance, particularly the high sensitivity and low detection limit, in complex matrices such as buffalo milk fortified with 2-FAL and in different commercial kinds of cow milk thermally treated for pasteurization. The measurements were carried out in about ten minutes by dropping the solution under-test on the planar D-shaped POF surface of the chemical chip. In contrast, on the gold surface of the SPR-POF platform, a water drop is always placed to excite the SPR phenomenon, which is modulated by the chemical chip via MIP-2-FAL binding. Furthermore, the experimental results demonstrated the pros and cons of the proposed sensor system. Thanks to the high sensitivity of the sensor system, the detection of 2-FAL in the diluted milk sample (1:50) was achieved. The dilution is required to reduce the interferent effect of the complex matrix.<\/jats:p>","DOI":"10.3390\/s22218289","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T10:47:57Z","timestamp":1667126877000},"page":"8289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Detection of 2-Furaldehyde in Milk by MIP-Based POF Chips Combined with an SPR-POF Sensor"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-2219","authenticated-orcid":false,"given":"Giancarla","family":"Alberti","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Pavia, Via Taramelli n.12, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-743X","authenticated-orcid":false,"given":"Francesco","family":"Arcadio","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Campania Luigi Vanvitelli, Via Roma n.29, 81031 Aversa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pesavento","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Pavia, Via Taramelli n.12, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-3790","authenticated-orcid":false,"given":"Chiara","family":"Marzano","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Campania Luigi Vanvitelli, Via Roma n.29, 81031 Aversa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-7480","authenticated-orcid":false,"given":"Luigi","family":"Zeni","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Campania Luigi Vanvitelli, Via Roma n.29, 81031 Aversa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji Abi","family":"Zeid","sequence":"additional","affiliation":[{"name":"Industrial Research Institute, Lebanese University Campus Hadath, Baabda 2806, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-0984","authenticated-orcid":false,"given":"Nunzio","family":"Cennamo","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Campania Luigi Vanvitelli, Via Roma n.29, 81031 Aversa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110839","DOI":"10.1016\/j.foodres.2021.110839","article-title":"Maillard reaction harmful products in dairy products: Formation, occurrence, analysis, and mitigation strategies","volume":"151","author":"Li","year":"2022","journal-title":"Food Res. 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