{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:12:47Z","timestamp":1773810767997,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2016\/25779-9"],"award-info":[{"award-number":["2016\/25779-9"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2018\/08782-1"],"award-info":[{"award-number":["2018\/08782-1"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["307501\/2019-1"],"award-info":[{"award-number":["307501\/2019-1"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["424027\/2018-6"],"award-info":[{"award-number":["424027\/2018-6"]}]},{"name":"CNPq","award":["2016\/25779-9"],"award-info":[{"award-number":["2016\/25779-9"]}]},{"name":"CNPq","award":["2018\/08782-1"],"award-info":[{"award-number":["2018\/08782-1"]}]},{"name":"CNPq","award":["307501\/2019-1"],"award-info":[{"award-number":["307501\/2019-1"]}]},{"name":"CNPq","award":["424027\/2018-6"],"award-info":[{"award-number":["424027\/2018-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A novel, low-cost, sensitive microwave microfluidic glucose detecting biosensor incorporating molecularly imprinted polymer (MIP) is presented. The sensing device is based on a stub resonator to characterize water glucose solutions. The tip of one of the stubs is coated with MIP to increase the selectivity of the sensor and hence the sensitivity compared to the uncoated or to the coated with non-imprinted polymer (NIP) sensor. The sensor was fabricated on a FR4 substrate for low-cost purposes. In the presence of the MIP, the sensor loaded with a glucose solution ranging from 50 mg\/dL to 400 mg\/dL is observed to experience an absorption frequency shift of 73 MHz when the solutions flow in a microfluidic channel passing sensing area, while the lower limit of detection (LLD) of the sensor is discovered to be 2.4 ng\/dL. The experimental results show a high sensitivity of 1.3 MHz\/(mg\/dL) in terms of absorption frequency.<\/jats:p>","DOI":"10.3390\/s22228648","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:11:15Z","timestamp":1668046275000},"page":"8648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Highly Sensitive Molecularly Imprinted Polymer (MIP)-Coated Microwave Glucose Sensor"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-1415","authenticated-orcid":false,"given":"Amir Hossein","family":"Omidvar","sequence":"first","affiliation":[{"name":"Department of Electronic Systems, Polytechnic School, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-5855","authenticated-orcid":false,"given":"Atena","family":"Amanati Shahri","sequence":"additional","affiliation":[{"name":"Department of Electronic Systems, Polytechnic School, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7623-9910","authenticated-orcid":false,"given":"Ariana Lacorte Caniato","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Electronic Systems, Polytechnic School, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-0199","authenticated-orcid":false,"given":"Jonas","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Fundamental Chemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-126X","authenticated-orcid":false,"given":"Gustavo","family":"Pamplona Rehder","sequence":"additional","affiliation":[{"name":"Department of Electronic Systems, Polytechnic School, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","unstructured":"(2022, July 30). The Top 10 Causes of Death. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"ref_2","unstructured":"(2022, May 30). IDF News. Available online: https:\/\/www.idf.org\/news\/240:diabetes-now-affects-one-in-10-adults-worldwide.html."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bios.2014.03.070","article-title":"Highly sensitive and selective glucose sensor based on ultraviolet-treated nematic liquid crystals","volume":"59","author":"Zhong","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1021\/cr068069y","article-title":"Electrochemical Glucose Sensors and Their Applications in Diabetes Management","volume":"108","author":"Heller","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0003-2670(99)00130-0","article-title":"Determination of glucose based on the effect of photons as a substitute for glucose oxidase","volume":"388","author":"Chen","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.elecom.2008.06.009","article-title":"Glucose biosensor based on gold nanoparticle-catalyzed luminol electrochemiluminescence on a three-dimensional sol\u2013gel network","volume":"10","author":"Liu","year":"2008","journal-title":"Electrochem. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.aca.2004.10.038","article-title":"An improved sampling approach in multi-pumping flow systems applied to the spectrophotometric determination of glucose and fructose in syrups","volume":"531","author":"Carneiro","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"012050","DOI":"10.1088\/1757-899X\/223\/1\/012050","article-title":"Preparation of immobilized glucose oxidase wafer enzyme on calcium-bentonite modified by surfactant","volume":"223","author":"Widi","year":"2017","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mehrotra, P., Chatterjee, B., and Sen, S. (2019). EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing. Sensors, 19.","DOI":"10.3390\/s19051013"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chebila, F., Jatlaoui, M.M., Pons, P., and Aubert, H. (2010, January 11\u201317). Pressure measurement from the RADAR interrogation of passive sensors. Proceedings of the 2010 IEEE International Symposium on Antennas and Propagation and CNC-USNC\/URSI Radio Science Meeting\u2014Leading the Wave, AP-S\/URSI 2010, Toronto, ON, Canada.","DOI":"10.1109\/APS.2010.5561726"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"075104","DOI":"10.1088\/1361-6501\/abe1e3","article-title":"A high sensitivity microwave glucose sensor","volume":"32","author":"Shahri","year":"2021","journal-title":"Meas. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chretiennot, T., Dubuc, D., and Grenier, K. (2014, January 1\u20136). Double stub resonant biosensor for glucose concentrations quantification of multiple aqueous solutions. Proceedings of the IEEE MTT-S International Microwave Symposium Digest, Tampa, FL, USA.","DOI":"10.1109\/MWSYM.2014.6848570"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1109\/JSTQE.2017.2659226","article-title":"Cost-Effective, Microstrip Antenna Driven Ring Resonator Microwave Biosensor for Biospecific Detection of Glucose","volume":"23","author":"Camli","year":"2017","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.proeng.2016.11.127","article-title":"A Microwave Ring Resonator Based Glucose Sensor","volume":"168","author":"Camli","year":"2016","journal-title":"Procedia Eng."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40538-019-0152-5","article-title":"Synthesis and characterization of molecular imprinting polymer for the removal of 2-phenylphenol from spiked blood serum and river water","volume":"6","author":"Bakhtiar","year":"2019","journal-title":"Chem. Biol. Technol. Agric."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"111830","DOI":"10.1016\/j.bios.2019.111830","article-title":"Integrating ionic liquids with molecular imprinting technology for biorecognition and biosensing: A review","volume":"149","author":"Ding","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.talanta.2015.06.027","article-title":"Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review","volume":"146","author":"Figueiredo","year":"2016","journal-title":"Talanta"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Becskereki, G., Horvai, G., and T\u00f3th, B. (2021). The Selectivity of Molecularly Imprinted Polymers. Polymers, 13.","DOI":"10.3390\/polym13111781"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11696-019-00860-4","article-title":"Voltammetric sensing of minoxidil using a molecularly imprinted polymer (MIP)-modified carbon paste electrode","volume":"74","author":"Dehdashtian","year":"2019","journal-title":"Chem. Pap."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1109\/JSEN.2014.2316819","article-title":"Application of Molecularly Imprinted Polymer for Determination of Glucose by Quartz Crystal Nanobalance Technique","volume":"14","author":"Mirmohseni","year":"2014","journal-title":"IEEE Sensors J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116487","DOI":"10.1016\/j.trac.2021.116487","article-title":"Sensor-based MIP technologies for targeted metabolomics analysis","volume":"146","author":"Ozcelikay","year":"2021","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"129107","DOI":"10.1016\/j.jhazmat.2022.129107","article-title":"Ultrasensitive, label-free voltammetric determination of norfloxacin based on molecularly imprinted polymers and Au nanoparticle-functionalized black phosphorus nanosheet nanocomposite","volume":"436","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_23","unstructured":"Pozar, D.M. (2012). Microwave Engineering, John Wiley &Sons, Inc.. [4th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.snb.2012.05.040","article-title":"MIP-based biomimetic sensor for the electronic detection of serotonin in human blood plasma","volume":"171\u2013172","author":"Peeters","year":"2012","journal-title":"Sensors Actuators B Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/1574885510999150505160637","article-title":"Optimization and Application of Imprinted Poly(AA-EGDMA) for Solid Phase Extraction of Ciprofloxacin in Artificial Urine","volume":"9","author":"Marestoni","year":"2015","journal-title":"Curr. 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