{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:34:09Z","timestamp":1774258449614,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007751","name":"AGH University of Science and Technology","doi-asserted-by":"publisher","award":["Excellence initiative\u2014research university"],"award-info":[{"award-number":["Excellence initiative\u2014research university"]}],"id":[{"id":"10.13039\/501100007751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Aceclofenac (ACL) is an anti-inflammatory drug, which is taken by patients who mainly suffer from rheumatoid conditions. In this work, we propose a new voltammetric method that allows the determination of ACL in pharmaceutics, urine, and plasma. As a working electrode, a glassy carbon electrode (GCE) modified with carbon nanofibers, carbon nanotubes, and NiCo nanoparticles (eCNF\/CNT\/NiCo-GCE) was used. The mentioned sensors are characterized by good repeatability and sensitivity, and their process of preparation is simple, fast, and cost-effective. Instrumental and method parameters were optimized, and the influence of interferences was investigated. To validate the analytical performance of the method, calibration was conducted. Good linearity was obtained (0.05\u20131.4 \u00b5M, r = 0.998), as well as excellent limit of detection (LOD) and limit of quantification (LOQ) values (0.7 nM and 2.1 nM, respectively). Calculated recoveries that were in the range of 98%\u2013105% indicate that this method is accurate and might be used in routine laboratory practice.<\/jats:p>","DOI":"10.3390\/s22228954","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:39:59Z","timestamp":1669005599000},"page":"8954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a New Voltammetric Method for Aceclofenac Determination on Glassy Carbon Electrode Modified with Hierarchical Nanocomposite"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7215-1698","authenticated-orcid":false,"given":"Anna","family":"G\u00f3rska","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-462X","authenticated-orcid":false,"given":"Beata","family":"Paczosa-Bator","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-6196","authenticated-orcid":false,"given":"Justina","family":"Gaidukevi\u010d","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, LT-03225 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-0609","authenticated-orcid":false,"given":"Robert","family":"Piech","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2165\/00003495-199652010-00008","article-title":"Aceclofenac: A Review of its Pharmacodynamic Properties and Therapeutic Potential in the Treatment of Rheumatic Disorders and in Pain Management","volume":"52","author":"Brogden","year":"1996","journal-title":"Drugs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2165\/00003495-200161090-00012","article-title":"Aceclofenac: A reappraisal of its use in the management of pain and rheumatic disease","volume":"61","author":"Dooley","year":"2001","journal-title":"Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2165\/00044011-199714030-00011","article-title":"Effects of Aceclofenac and Diclofenac on Synovial Inflammatory Factors in Human Osteoarthritis","volume":"14","author":"Cloutier","year":"1997","journal-title":"Clin. 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