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or mediated chemical reaction, which has major applications in the field of enhancing sensing and enables opportunities in developing healthcare monitoring. This review presents an updated overview of the recent exciting advances of plasmonic biosensors in the healthcare area. Manufacturing, enhancements and applications of plasmonic biosensors are discussed, with particular focus on nanolisted main preparation methods of various nanostructures, such as chemical synthesis, lithography, nanosphere lithography, nanoimprint lithography, etc., and describing their respective advances and challenges from practical applications of plasmon biosensors. Based on these sensing structures, different types of plasmonic biosensors are summarized regarding detecting cancer biomarkers, body fluid, temperature, gas and COVID-19. Last, the existing challenges and prospects of plasmonic biosensors combined with machine learning, mega data analysis and prediction are surveyed.<\/jats:p>","DOI":"10.3390\/s23010445","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T03:08:59Z","timestamp":1672628939000},"page":"445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Plasmonic Biosensors with Nanostructure for Healthcare Monitoring and Diseases Diagnosis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6964-1266","authenticated-orcid":false,"given":"Tongge","family":"An","sequence":"first","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Wen","sequence":"additional","affiliation":[{"name":"The College of Electronics and Information, Hangzhou Dianzi University, Hangzhou 310018, China"},{"name":"Shangyu Institute of Science and Engineering, Hangzhou Dianzi University, Shaoxing 312000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faxiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China"},{"name":"Zhejiang Laboratory, Hangzhou 311100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18822","DOI":"10.1021\/acsnano.1c07176","article-title":"Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects","volume":"15","author":"Song","year":"2021","journal-title":"ACS Nano"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1021\/acsanm.2c02392","article-title":"Label-Free Sensing with Metal Nanostructure-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis","volume":"5","author":"Constantinou","year":"2022","journal-title":"ACS Appl. 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