{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:06:31Z","timestamp":1787029591046,"version":"build-2736575974"},"reference-count":88,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Transcranial magnetic stimulation (TMS) is a noninvasive technique mainly used for the assessment of corticospinal tract integrity and excitability of the primary motor cortices. Motor evoked potentials (MEPs) play a pivotal role in TMS studies. TMS clinical guidelines, concerning the use and interpretation of MEPs in diagnosing and monitoring corticospinal tract integrity in people with multiple sclerosis (pwMS), were established almost ten years ago and refer mainly to the use of TMS implementation; this comprises the magnetic stimulator connected to a standard EMG unit, with the positioning of the coil performed by using the external landmarks on the head. The aim of the present work was to conduct a narrative literature review on the MEP assessment and outcome measures in clinical and research settings, assessed by TMS Methodological characteristics of different TMS system implementations (TMS without navigation, line-navigated TMS and e-field-navigated TMS); these were discussed in the context of mapping the corticospinal tract integrity in MS. An MEP assessment of two case reports, by using an e-field-navigated TMS, was presented; the results of the correspondence between the e-field-navigated TMS with MRI, and the EDSS classifications were presented. Practical and technical guiding principles for the improvement of TMS studies in MEP assessment for MS are discussed, suggesting the use of e-field TMS assessment in the sense that it can improve the accuracy of corticospinal tract integrity testing by providing a more objective correspondence of the neurophysiological (e-field-navigated TMS) and clinical (Expanded Disability Status Scale\u2014EDSS) classifications.<\/jats:p>","DOI":"10.3390\/s23010497","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:56:27Z","timestamp":1672635387000},"page":"497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of Motor Evoked Potentials in Multiple Sclerosis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-8026","authenticated-orcid":false,"given":"Jo\u0161ko","family":"\u0160oda","sequence":"first","affiliation":[{"name":"Signal Processing, Analysis, and Advanced Diagnostics Research and Education Laboratory (SPAADREL), Faculty of Maritime Studies, University of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda","family":"Pavelin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-1461","authenticated-orcid":false,"given":"Igor","family":"Vujovi\u0107","sequence":"additional","affiliation":[{"name":"Signal Processing, Analysis, and Advanced Diagnostics Research and Education Laboratory (SPAADREL), Faculty of Maritime Studies, University of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-9718","authenticated-orcid":false,"given":"Maja","family":"Rogi\u0107 Vidakovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Human and Experimental Neurophysiology, Department of Neuroscience, School of Medicine, University of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Goodin, D.S., Khankhanian, P., Gourraud, P.-A., and Vince, N. (2021). The nature of genetic and environmental susceptibility to multiple sclerosis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246157"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and Treatment of Multiple Sclerosis: A Review","volume":"325","author":"McGinley","year":"2021","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1474-4422(21)00095-8","article-title":"2021 MAGNIMS\u2013CMSC\u2013NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis","volume":"20","author":"Wattjes","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref_6","unstructured":"Kappos, L. (2009). Definitions for a Standardised, Quantified Neurological Examination and Assessment of Kurtzke\u2019s Functional Systems and Expanded Disability Status Scale in Multiple Sclerosis, University Hospital Basel. Available online: https:\/\/www.neurostatus.net\/media\/specimen\/Definitions_0309_specimen.pdf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000369621","article-title":"Relationship between sustained disability progression and functional system scores in relapsing-remitting multiple sclerosis: Analysis of placebo data from four randomized clinical trials","volume":"44","author":"Scott","year":"2015","journal-title":"Neuroepidemiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00234-018-02150-4","article-title":"MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis","volume":"61","author":"Cocozza","year":"2019","journal-title":"Neuroradiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000519772","article-title":"Design and Validation of an Expanded Disability Status Scale Model in Multiple Sclerosis","volume":"85","author":"Sanz","year":"2022","journal-title":"Eur. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/cns.13734","article-title":"Correlation between the clinical disability and T1 hypointense lesions\u2019 volume in cerebral magnetic resonance imaging of multiple sclerosis patients: A systematic review and meta-analysis","volume":"27","author":"Valizadeh","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fneur.2020.00735","article-title":"Validation of Quantitative Scores Derived From Motor Evoked Potentials in the Assessment of Primary Progressive Multiple Sclerosis: A Longitudinal Study","volume":"11","author":"Hardmeier","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1177\/1352458514525867","article-title":"Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years","volume":"20","author":"Schlaeger","year":"2014","journal-title":"Mult. Scler."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"635612","DOI":"10.3389\/fneur.2020.635612","article-title":"Editorial: Corticospinal Excitability in Patients With Multiple Sclerosis","volume":"11","author":"Chalah","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbr.2015.10.015","article-title":"Multiple measures of corticospinal excitability are associated with clinical features of multiple sclerosis","volume":"297","author":"Neva","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fneur.2020.00566","article-title":"Inflammation and Corticospinal Functioning in Multiple Sclerosis: A TMS Perspective","volume":"11","author":"Bassi","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/ane.13289","article-title":"Neurophysiological impairments in multiple sclerosis\u2014Central and peripheral motor pathways","volume":"142","author":"Mamoei","year":"2020","journal-title":"Acta Neurol. Scand."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.clinph.2015.02.001","article-title":"Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee","volume":"126","author":"Rossini","year":"2015","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1212\/WNL.41.9.1505","article-title":"Plasticity of central motor pathways in children with hemiplegic cerebral palsy","volume":"41","author":"Farmer","year":"1991","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/brain\/116.5.1223","article-title":"Patterns of central motor reorganization in hemiplegic cerebral palsy","volume":"116","author":"Carr","year":"1993","journal-title":"Brain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-2007-973695","article-title":"Mechanisms of central motor reorganization in pediatric hemiplegic patients","volume":"28","author":"Maegaki","year":"1997","journal-title":"Neuropediatrics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1093\/brain\/awf227","article-title":"Two types of ipsilateral reorganization in congenital hemiparesis: A TMS and fMRI study","volume":"125 Pt 10","author":"Staudt","year":"2002","journal-title":"Brain"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kowalski, J.L., Nemanich, S.T., Nawshin, T., Chen, M., Peyton, C., Zorn, E., Hickey, M., Rao, R., Georgieff, M., and Rudser, K. (2019). Motor Evoked Potentials as Potential Biomarkers of Early Atypical Corticospinal Tract Development in Infants with Perinatal Stroke. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081208"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00314672","article-title":"Magnetic stimulation study in mirror movements","volume":"237","author":"Konagaya","year":"1990","journal-title":"J. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0387-7604(98)00094-1","article-title":"Functional recovery in hemiplegic cerebral palsy: Ipsilateral electromyographic responses to focal transcranial magnetic stimulation","volume":"21","author":"Nezu","year":"1999","journal-title":"Brain Dev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1550059419899323","article-title":"Ipsilateral Corticospinal Tract Excitability Contributes to the Severity of Mirror Movements in Unilateral Cerebral Palsy: A Case Series","volume":"51","author":"Rich","year":"2020","journal-title":"Clin. EEG Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.4103\/1673-5374.250581","article-title":"Ipsilateral motor evoked potentials in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis","volume":"14","author":"Nardone","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s00586-006-0190-0","article-title":"Intraoperative monitoring study of ipsilateral motor evoked potentials in scoliosis surgery","volume":"15","author":"Lo","year":"2006","journal-title":"Eur. Spine J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF00231167","article-title":"Reorganisation of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation","volume":"83","author":"Benecke","year":"1991","journal-title":"Exp. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.brs.2022.05.007","article-title":"Ipsilateral corticospinal maps correspond to severe poststroke motor impairment","volume":"15","author":"Trunk","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1469-7793.1999.0895p.x","article-title":"Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles","volume":"518","author":"Ziemann","year":"1999","journal-title":"J. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1073858405283392","article-title":"How can corticospinal tract neurons contribute to ipsilateral movements? A question with implications for recovery of motor functions","volume":"12","author":"Jankowska","year":"2006","journal-title":"Neuroscientist"},{"key":"ref_32","first-page":"505","article-title":"Clinical value of the assessment of changes in MEP duration with voluntary contraction","volume":"9","author":"Brum","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1006\/nimg.2002.1313","article-title":"Contribution of corticospinal tract damage to cortical motor reorganization after a single clinical attack of multiple sclerosis","volume":"17","author":"Pantano","year":"2002","journal-title":"NeuroImage"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/jnnp.2010.219964","article-title":"Functional role of ipsilateral motor areas in multiple sclerosis","volume":"82","author":"Zeller","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nicl.2017.09.019","article-title":"How changes in brain activity and connectivity are associated with motor performance in people with MS","volume":"17","author":"Peterson","year":"2017","journal-title":"NeuroImage Clin."},{"key":"ref_36","first-page":"408","article-title":"Recommendations for the clinical use of motor evoked potentials in multiple sclerosis","volume":"28","author":"Fernandez","year":"2013","journal-title":"Neurologia"},{"key":"ref_37","unstructured":"Krieg, S.M. (2017). Basic Principles of navigated TMS. Navigated Transcranial Magnetic Stimulation in Neurosurgery, Springer International Publishing AG."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/brain\/120.1.141","article-title":"Localization of the motor hand area to a knob on the precentral gyrus. A new landmark","volume":"120","author":"Yousry","year":"1997","journal-title":"Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s00701-016-2970-6","article-title":"Comparison between electric-field-navigated and line-navigated TMS for cortical motor mapping in patients with brain tumors","volume":"158","author":"Sollmann","year":"2016","journal-title":"Acta Neurochir."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneumeth.2008.06.032","article-title":"Navigated transcranial magnetic stimulation and computed electric field strength reduce stimulator-dependent differences in the motor threshold","volume":"174","author":"Danner","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/hbm.22611","article-title":"Nonphysiological factors in navigated TMS studies; Confounding covariates and valid intracortical estimates","volume":"36","author":"Schmidt","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clinph.2022.04.022","article-title":"Transcranial magnetic stimulation of the brain: What is stimulated?\u2014A consensus and critical position paper","volume":"140","author":"Siebner","year":"2022","journal-title":"Clin. Neurophysiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.clinph.2015.08.011","article-title":"Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions","volume":"127","author":"Nantes","year":"2016","journal-title":"Clin. Neurophysiol."},{"key":"ref_44","first-page":"E33","article-title":"Abstracts from the IFESS 2021 conferences (Abstract\u201445 Neurophysiological impairment in multiple sclerosis patient confirmed by transcranial magnetic stimulation of the central nervous system but not with electrical stimulation of peripheral nervous system)","volume":"46","author":"Kosta","year":"2022","journal-title":"Artif. Organs."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.clinph.2019.11.024","article-title":"Upper limb motor evoked potentials as outcome measure in progressive multiple sclerosis","volume":"131","author":"Pisa","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"758710","DOI":"10.3389\/fneur.2021.758710","article-title":"Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis\u2014An Explorative Study","volume":"12","author":"Mamoei","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41597-022-01335-0","article-title":"Motor evoked potentials for multiple sclerosis, a multiyear follow-up dataset","volume":"9","author":"Yperman","year":"2022","journal-title":"Sci. Data"},{"key":"ref_48","unstructured":"Rogi\u0107 Vidakovi\u0107, M., \u0106urkovi\u0107 Kati\u0107, A., and Pavelin, S. (2022). Corticospinal excitability assessment with navigated TMS corresponds to MRI and the EDSS classifications in relapsing-remitting multiple sclerosis. Eur. J. Neurol., submitted (in review)."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1177\/1352458520960374","article-title":"Intracortical motor conduction is associated with hand dexterity in progressive multiple sclerosis","volume":"27","author":"Pisa","year":"2021","journal-title":"Mult. Scler."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fneur.2019.00339","article-title":"Fatigue in multiple sclerosis: General and perceived fatigue does not depend on corticospinal tract dysfunction","volume":"10","author":"Dileone","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fnins.2018.00393","article-title":"Cortical excitability and interhemispheric connectivity in early relapsing\u2013remitting multiple sclerosis studied with TMS-EEG","volume":"12","author":"Zipser","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1152\/jn.00591.2014","article-title":"Defective sensorimotor integration in preparation for reaction time tasks in patients with multiple sclerosis","volume":"113","author":"Cabib","year":"2015","journal-title":"J. Neurophysiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jns.2015.05.006","article-title":"Impaired sleep-associated modulation of post-exercise corticomotor depression in multiple sclerosis","volume":"354","author":"Bridoux","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.clinph.2013.06.018","article-title":"A new neurophysiological approach to assess central motor conduction damage to proximal and distal muscles of lower limbs","volume":"125","author":"Bertolotto","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1148\/radiol.13112776","article-title":"Spinal cord diffusion-tensor imaging and motor-evoked potentials in multiple sclerosis patients: Microstructural and functional asymmetry","volume":"267","author":"Wilm","year":"2013","journal-title":"Radiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00415-009-5047-0","article-title":"Intracortical excitability in patients with relapsing\u2013remitting and secondary progressive multiple sclerosis","volume":"256","author":"Conte","year":"2009","journal-title":"J. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.clinph.2012.05.008","article-title":"The latency distribution of motor evoked potentials in patients with multiple sclerosis","volume":"123","author":"Firmin","year":"2012","journal-title":"Clin. Neurophysiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1016\/j.neuroimage.2011.11.038","article-title":"Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: A combined electrophysiological and neuroimaging study","volume":"59","author":"Steens","year":"2011","journal-title":"Neuroimage"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00415-010-5742-x","article-title":"Is central fatigue in multiple sclerosis a disorder of movement preparation?","volume":"258","author":"Morgante","year":"2011","journal-title":"J. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00415-008-0818-6","article-title":"Enhanced corticomotor excitability with dynamic fatiguing exercise of the lower limb in multiple sclerosis","volume":"255","author":"Thickbroom","year":"2008","journal-title":"J. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00415-006-0334-5","article-title":"Motor evoked potentials in multiple sclerosis patients without walking limitation: Amplitude vs. conduction time abnormalities","volume":"254","author":"Gagliardo","year":"2007","journal-title":"J. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s00415-006-0159-2","article-title":"Central motor drive and perception of effort during fatigue in multiple sclerosis","volume":"253","author":"Thickbroom","year":"2006","journal-title":"J. Neurol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1191\/1352458505ms1163oa","article-title":"Motor cortex excitability and fatigue in multiple sclerosis: A transcranial magnetic stimulation study","volume":"11","author":"Liepert","year":"2005","journal-title":"Mult. Scler."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1212\/01.WNL.0000129263.14219.A8","article-title":"Enhanced brain motor activity in patients with MS after a single dose of 3,4-diaminopyridine","volume":"62","author":"Mainero","year":"2004","journal-title":"Neurology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/(SICI)1097-4598(199808)21:8<1068::AID-MUS12>3.0.CO;2-Q","article-title":"Walking and fatigue in multiple sclerosis: The role of the corticospinal system","volume":"21","author":"Schubert","year":"1998","journal-title":"Muscle Nerve"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/brain\/120.2.299","article-title":"An electrophysiological study of the mechanism of fatigue in multiple sclerosis","volume":"120 Pt 2","author":"Sheean","year":"1997","journal-title":"Brain"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"628903","DOI":"10.3389\/fneur.2020.628903","article-title":"Preoperative Applications of Navigated Transcranial Magnetic Stimulation","volume":"11","author":"Haddad","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"193356","DOI":"10.1109\/ACCESS.2020.3033075","article-title":"A Novel Latency Estimation Algorithm of Motor Evoked Potential Signals","volume":"8","author":"Soda","year":"2020","journal-title":"IEEE Access"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fninf.2019.00008","article-title":"Motometrics: A toolbox for annotation and efficient analysis of motor evoked potentials","volume":"13","author":"Giridharan","year":"2019","journal-title":"Front. Neuroinform."},{"key":"ref_70","unstructured":"Harquel, S., Beynel, L., Guyader, N., Marendaz, C., David, O., and Chauvin, A. (2022, November 15). CortExTool: A Toolbox for Processing Motor Cortical Excitability Measurements by Transcranial Magnetic Stimulation. Available online: https:\/\/hal.archives-ouvertes.fr\/hal-01390016."},{"key":"ref_71","unstructured":"Harquel, S. (2017). Robotized Transcranial Magnetic Stimulation: From Automatized Protocols towards New Approaches in Functional Neu Roimaging. [Ph.D. Dissertation, Grenoble Institut des Neurosciences, Laboratoire de Psychologie et NeuroCognition, Neurosciences, Universit\u00e9 Greno ble-Alpes]. Available online: https:\/\/tel.archives-ouvertes.fr\/tel-01504993."},{"key":"ref_72","unstructured":"(2014). MEPHunter, a Free Software for Signal Visualization and Analysis, NeuroMat."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"024002","DOI":"10.1088\/1741-2552\/ac636c","article-title":"An automatized method to determine latencies of motor-evoked potentials under physiological and pathophysiological conditions","volume":"19","author":"Bigoni","year":"2022","journal-title":"J. Neural Eng."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1109\/TNSRE.2017.2779135","article-title":"Oscillatory TMS-EEG-Responses as a Measure of the Cortical Excitability Threshold","volume":"26","author":"Saari","year":"2018","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.brs.2012.05.010","article-title":"A Comparison of two methods in acquiring stimulus\u2013response curves with transcranial magnetic stimulation","volume":"6","author":"Pearce","year":"2013","journal-title":"Brain Stimul."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00221-008-1294-z","article-title":"The effects of low- and high-frequency repetitive TMS on the input\/output properties of the human corticospinal pathway","volume":"187","author":"Houdayer","year":"2008","journal-title":"Exp. Brain Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1388-2457(99)00198-4","article-title":"Influence of pulse configuration and direction of coil current on excitatory effects of magnetic motor cortex and nerve stimulation","volume":"111","author":"Niehaus","year":"2000","journal-title":"Clin. Neurophysiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/PL00005641","article-title":"Input-output properties and gain changes in the human corticospinal pathway","volume":"114","author":"Devanne","year":"1997","journal-title":"Exp. Brain Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.brs.2014.03.002","article-title":"A Novel Model Incorporating Two Variability Sources for Describing Motor Evoked Potentials","volume":"7","author":"Goetz","year":"2014","journal-title":"Brain Stimul."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1109\/TNSRE.2019.2926543","article-title":"Statistical Model of Motor-Evoked Potentials","volume":"27","author":"Goetz","year":"2019","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/S1388-2457(11)60148-X","article-title":"W14.4 Amplitude values of motor evoked potentials: Statistical properties and neurophysiological implications","volume":"122","author":"Pasqualetti","year":"2011","journal-title":"Clin. Neurophysiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1152\/jn.1995.73.6.2608","article-title":"Motor facilitation during action observation: A magnetic stimulation study","volume":"73","author":"Fadiga","year":"1995","journal-title":"J. Neurophysiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0168-5597(93)90115-6","article-title":"Variability of motor potentials evoked by transcranial magnetic stimulation","volume":"89","author":"Kiers","year":"1993","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0168-5597(89)90029-4","article-title":"Focal stimulation of human cerebral cortex with the magnetic coil: A comparison with electrical stimulation","volume":"74","author":"Amassian","year":"1989","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"066037","DOI":"10.1088\/1741-2552\/aca71a","article-title":"Accuracy and precision of navigated transcranial magnetic stimulation","volume":"19","author":"Nieminen","year":"2022","journal-title":"J. Neural Eng."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2002-23583","article-title":"Error analysis in cranial neuronavigation","volume":"45","author":"Spetzger","year":"2002","journal-title":"Minim Invasive Neurosurg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rcs.441","article-title":"Frameless stereotactic targeting devices: Technical features, targeting errors and clinical results","volume":"8","author":"Widmann","year":"2011","journal-title":"Int. J. Med. Robot."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuroimage.2018.12.053","article-title":"A principled approach to conductivity uncertainty analysis in electric field calculations","volume":"188","author":"Saturnino","year":"2018","journal-title":"Neuroimage"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/1\/497\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:56:18Z","timestamp":1760118978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/1\/497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["s23010497"],"URL":"https:\/\/doi.org\/10.3390\/s23010497","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]}}}