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Chemical Environmental Protection Industry Joint Laboratory","award":["92066207"],"award-info":[{"award-number":["92066207"]}]},{"name":"Lanzhou University-Jinchuan Group Chemical Co., Ltd. Chemical Environmental Protection Industry Joint Laboratory","award":["2021JLM-27"],"award-info":[{"award-number":["2021JLM-27"]}]},{"name":"Lanzhou University-Jinchuan Group Chemical Co., Ltd. Chemical Environmental Protection Industry Joint Laboratory","award":["2023-CX-TD-49"],"award-info":[{"award-number":["2023-CX-TD-49"]}]},{"name":"Lanzhou University-Jinchuan Group Chemical Co., Ltd. Chemical Environmental Protection Industry Joint Laboratory","award":["2020TD-001"],"award-info":[{"award-number":["2020TD-001"]}]},{"name":"Lanzhou University-Jinchuan Group Chemical Co., Ltd. Chemical Environmental Protection Industry Joint Laboratory","award":["(20)0837"],"award-info":[{"award-number":["(20)0837"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Designing highly active material to fabricate a high-performance noninvasive wearable glucose sensor was of great importance for diabetes monitoring. In this work, we developed CuxO nanoflakes (NFs)\/Cu nanoparticles (NPs) nanocomposites to serve as the sensing materials for noninvasive sweat-based wearable glucose sensors. We involve CuCl2 to enhance the oxidation of Cu NPs to generate Cu2O\/CuO NFs on the surface. Due to more active sites endowed by the CuxO NFs, the as-prepared sample exhibited high sensitivity (779 \u03bcA mM\u22121 cm\u22122) for noninvasive wearable sweat sensing. Combined with a low detection limit (79.1 nM), high selectivity and the durability of bending and twisting, the CuxO NFs\/Cu NPs-based sensor can detect the glucose level change of sweat in daily life. Such a high-performance wearable sensor fabricated by a convenient method provides a facile way to design copper oxide nanomaterials for noninvasive wearable glucose sensors.<\/jats:p>","DOI":"10.3390\/s23020695","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T06:38:27Z","timestamp":1673246307000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Wearable Noninvasive Glucose Sensor Based on CuxO NFs\/Cu NPs Nanocomposites"],"prefix":"10.3390","volume":"23","author":[{"given":"Zhipeng","family":"Yu","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongshuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimao","family":"Yang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-2882","authenticated-orcid":false,"given":"Jian","family":"Lv","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuncai","family":"Kong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130379","DOI":"10.1016\/j.snb.2021.130379","article-title":"Highly sensitive and portable electrochemical detection system based on AuNPs@CuO NWs\/Cu2O\/CF hierarchical nanostructures for enzymeless glucose sensing","volume":"345","author":"Zhao","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Metelka, R., Vlasakova, P., Smarzewska, S., Guziejewski, D., Vlcek, M., and Sys, M. (2022). Screen-Printed Carbon Electrodes with Macroporous Copper Film for Enhanced Amperometric Sensing of Saccharides. Sensors, 22.","DOI":"10.3390\/s22093466"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1021\/acs.accounts.8b00451","article-title":"Wearable Bioelectronics: Enzyme-Based Body-Worn Electronic Devices","volume":"51","author":"Kim","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cappon, G., Acciaroli, G., Vettoretti, M., Facchinetti, A., and Sparacino, G. (2017). Wearable Continuous Glucose Monitoring Sensors: A Revolution in Diabetes Treatment. Electronics, 6.","DOI":"10.3390\/electronics6030065"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.apsusc.2018.11.101","article-title":"Highly sensitive wearable glucose sensor systems based on functionalized single-wall carbon nanotubes with glucose oxidase-nafion composites","volume":"470","author":"Kang","year":"2019","journal-title":"Appl. Surf. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bios.2017.04.038","article-title":"Eggshell membrane-templated synthesis of 3D hierarchical porous Au networks for electrochemical nonenzymatic glucose sensor","volume":"96","author":"Zhong","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129409","DOI":"10.1016\/j.snb.2020.129409","article-title":"Electrochemical glucose sensor based on the glucose oxidase entrapped in chitosan immobilized onto laser-processed Au-Ti electrode","volume":"330","author":"Siuzdak","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jiang, M., Sun, P., Zhao, J., Huo, L., and Cui, G. (2019). A Flexible Portable Glucose Sensor Based on Hierarchical Arrays of Au@Cu(OH)2 Nanograss. Sensors, 19.","DOI":"10.3390\/s19225055"},{"key":"ref_9","first-page":"7271","article-title":"Nonenzymatic electrochemical detection of glucose based on palladium-single-walled carbon nanotube hybrid nanostructures","volume":"81","author":"Meng","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.snb.2015.09.047","article-title":"In situ reduction of the Cu\/Cu2O\/carbon spheres composite for enzymaticless glucose sensors","volume":"222","author":"Yin","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mazurkow, J., Kusior, A., and Radecka, M. (2021). Nonenzymatic Glucose Sensors Based on Copper Sulfides: Effect of Binder-Particles Interactions in Drop-Casted Suspensions on Electrodes Electrochemical Performance. Sensors, 21.","DOI":"10.3390\/s21030802"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jelechem.2018.10.054","article-title":"New route for the synthesis of nickel (II) oxide nanostructures and its application as non-enzymatic glucose sensor","volume":"832","author":"Heyser","year":"2019","journal-title":"J. Electroanal. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"126945","DOI":"10.1016\/j.snb.2019.126945","article-title":"Three-dimensional porous Ni, N-codoped C networks for highly sensitive and selective non-enzymatic glucose sensing","volume":"299","author":"Chen","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1039\/c3ay00067b","article-title":"Non-enzymatic glucose sensor based on three dimensional nickel oxide for enhanced sensitivity","volume":"5","author":"Guo","year":"2013","journal-title":"Anal. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13747","DOI":"10.1021\/acsanm.1c03149","article-title":"Nano- and Microstructured Copper\/Copper Oxide Composites on Laser-Induced Carbon for Enzyme-Free Glucose Sensors","volume":"4","author":"Mamleyev","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.electacta.2011.11.066","article-title":"Application of a Cu-Co alloy dendrite on glucose and hydrogen peroxide sensors","volume":"61","author":"Noh","year":"2012","journal-title":"Electrochim. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.bios.2009.08.013","article-title":"Three-dimensional network films of electrospun copper oxide nanofibers for glucose determination","volume":"25","author":"Wang","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jallcom.2019.06.160","article-title":"CuO ultrathin nanosheets decorated reduced graphene oxide as a high performance anode for lithium-ion batteries","volume":"805","author":"Pu","year":"2019","journal-title":"J. Alloys Compd."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.matlet.2018.02.067","article-title":"Template-synthesis of hierarchical CuO nanoflowers constructed by ultrathin nanosheets and their application for non-enzymatic glucose detection","volume":"219","author":"Kong","year":"2018","journal-title":"Mater. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"152389","DOI":"10.1016\/j.apsusc.2021.152389","article-title":"High-performance non-enzymatic glucose sensor based on flower-like Cu2O-Cu-Au ternary nanocomposites","volume":"581","author":"Pu","year":"2022","journal-title":"Appl. Surf. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lan, T., Fallatah, A., Suiter, E., and Padalkar, S. (2017). Size Controlled Copper (I) Oxide Nanoparticles Influence Sensitivity of Glucose Biosensor. Sensors, 17.","DOI":"10.3390\/s17091944"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.snb.2017.12.035","article-title":"A highly sensitive non-enzymatic glucose sensor based on Cu\/Cu2O\/CuO ternary composite hollow spheres prepared in a furnace aerosol reactor","volume":"259","author":"Lin","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1039\/C4NR05620E","article-title":"Flexible 3D porous CuO nanowire arrays for enzymeless glucose sensing: In situ engineered versus ex situ piled","volume":"7","author":"Huang","year":"2015","journal-title":"Nanoscale"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Motoc, S., Cretu, C., Costisor, O., Baciu, A., Manea, F., and Szerb, E.I. (2019). Cu(I) Coordination Complex Precursor for Randomized CuOx Microarray Loaded on Carbon Nanofiber with Excellent Electrocatalytic Performance for Electrochemical Glucose Detection. Sensors, 19.","DOI":"10.3390\/s19245353"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"087503","DOI":"10.1149\/1945-7111\/ac1810","article-title":"RGO@Cu2O@Cu Ternary Nanocomposite for High-Performance Non-Enzymatic Glucose Detection","volume":"168","author":"Pu","year":"2021","journal-title":"J. Electrochem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0021-9673(95)00757-1","article-title":"Copper electrodes for stable subpicomole detection of carbohydrates in high-performance liquid chromatography","volume":"721","author":"Kano","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-0728(93)03252-K","article-title":"Electrocatalytic oxidation of carbohydrates at copper (II)-modified electrodes and its application to flow-through detection","volume":"372","author":"Kano","year":"1994","journal-title":"J. Electroanal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1021\/ac00017a012","article-title":"Electrocatalysis and Amperometric Detection Using an Electrode Made of Copper-Oxide and Carbon Paste","volume":"63","author":"Xie","year":"1991","journal-title":"Anal. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1039\/b509784c","article-title":"Microwave activation of the electro-oxidation of glucose in alkaline media","volume":"7","author":"Ghanem","year":"2005","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00604-010-0415-0","article-title":"Addition of porous cuprous oxide to a Nafion film strongly improves the performance of a nonenzymatic glucose sensor","volume":"171","author":"Zhang","year":"2010","journal-title":"Microchim. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"59099","DOI":"10.1039\/C5RA08586A","article-title":"A feasible approach to synthesize Cu2O microcrystals and their enhanced non-enzymatic sensor performance","volume":"5","author":"Liu","year":"2015","journal-title":"RSC Adv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00604-012-0923-1","article-title":"Non-enzymatic electrochemical sensing of glucose","volume":"180","author":"Wang","year":"2013","journal-title":"Microchim. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bios.2017.01.058","article-title":"A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration","volume":"91","author":"Jeerapan","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.snb.2017.04.052","article-title":"Facile synthesis of novel CuO\/Cu2O nanosheets on copper foil for high sensitive nonenzymatic glucose biosensor","volume":"248","author":"Lv","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"156635","DOI":"10.1016\/j.jallcom.2020.156635","article-title":"Template-assisted synthesis of CuO hollow nanotubes constructed by ultrathin nanosheets for lithium-ion battery applications","volume":"849","author":"Kong","year":"2020","journal-title":"J. Alloys Compd."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"135630","DOI":"10.1016\/j.electacta.2020.135630","article-title":"A highly sensitive non-enzymatic glucose sensor based on CuS nanosheets modified Cu2O\/CuO nanowire arrays","volume":"334","author":"Wei","year":"2020","journal-title":"Electrochim. Acta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100453","DOI":"10.1016\/j.sbsr.2021.100453","article-title":"Nonenzymatic electrochemical sensors via Cu native oxides (CuNOx) for sweat glucose monitoring","volume":"34","author":"Alam","year":"2021","journal-title":"Sens. Bio-Sens. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"110216","DOI":"10.1016\/j.msec.2019.110216","article-title":"A non-enzymatic sensor based on three-dimensional graphene foam decorated with Cu-xCu2O nanoparticles for electrochemical detection of glucose and its application in human serum","volume":"108","author":"Khosroshahi","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.synthmet.2018.08.021","article-title":"Non-enzymatic glucose sensor based on copper oxide and multi-wall carbon nanotubes using PEDOT:PSS matrix","volume":"245","author":"Amirzadeh","year":"2018","journal-title":"Synth. Met."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1039\/C5RA22940E","article-title":"Self-assembly of porous copper oxide hierarchical nanostructures for selective determinations of glucose and ascorbic acid","volume":"6","author":"Mahmoud","year":"2016","journal-title":"RSC Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"125076","DOI":"10.1016\/j.colsurfa.2020.125076","article-title":"One-step hydrothermal synthesis of Cu2O\/CuO hollow microspheres\/reduced graphene oxide hybrid with enhanced sensitivity for non-enzymatic glucose sensing","volume":"602","author":"Zhang","year":"2020","journal-title":"Colloid Surf. 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