{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:13:07Z","timestamp":1792789987832,"version":"4.5.0"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RC2018\u20132634475"],"award-info":[{"award-number":["RC2018\u20132634475"]}]},{"name":"Sicilian regional PO-FESR 2014-2020-Action 1.1.5 Project 3DLab Sicily-USE CASE: COREV-LAB (COgnitive REhabilitation Virtual reality\u2014laboratory)","award":["RC2018\u20132634475"],"award-info":[{"award-number":["RC2018\u20132634475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Virtual reality has gained attention as an effective tool for cognitive, motor, and daily activity rehabilitation in patients with major neurocognitive disorder (M-NCD). The first objective of this study was to check for differences between M-NCD caused by degenerative and non-degenerative conditions (DC and NDC, respectively) in terms of relearning four functional living skills (FLSs), by means of a non-immersive virtual reality training (VRT). The second purpose was to verify whether spontaneous transfer from the virtual environment to the real environment occurred. Four FLS apps were developed in our institute (Information, Suitcase, Medicine, and Supermarket). A nonrandomized interventional study was carried out, comparing experimental and control groups (EG and CG, respectively). The study included three phases: in vivo test at T1; VRT at T2 only for EG; in vivo test at T3. During the in vivo test, the four FLSs were assessed in their natural environments. Both EG-DC and EG-NDC significantly improved in all of the VRT variable scores (the EG-NDC group seemed to show better outcomes than the EG-DC group). Moderate-to-high satisfaction with the VRT was reported. EG-DC and EG-NDC also enhanced their performances in the in vivo test. No statistically significant differences between them were found. CG-DC and CG-NDC improved only in the execution time of Information in the in vivo test. These findings confirm the ecological validity of VRT for FLSs.<\/jats:p>","DOI":"10.3390\/s23041896","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T04:21:59Z","timestamp":1675830119000},"page":"1896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Functional Living Skills in Patients with Major Neurocognitive Disorder Due to Degenerative or Non-Degenerative Conditions: Effectiveness of a Non-Immersive Virtual Reality Training"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5240-6756","authenticated-orcid":false,"given":"Simonetta","family":"Panerai","sequence":"first","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Catania","sequence":"additional","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rundo","sequence":"additional","affiliation":[{"name":"Unit of Bioinformatics and Statistics, Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Tasca","sequence":"additional","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Musso","sequence":"additional","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-9839","authenticated-orcid":false,"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Prestianni","sequence":"additional","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Muratore","sequence":"additional","affiliation":[{"name":"Unit of Psychology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Unit of Neurology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Publishing. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnbeh.2016.00034","article-title":"Group Intensive Cognitive Activation in Patients with Major or Mild Neurocognitive Disorder","volume":"10","author":"Panerai","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3109\/02813439209014049","article-title":"Risk factors for admission to a nursing home. A study of elderly people receiving home nursing","volume":"10","author":"Nygaard","year":"1992","journal-title":"Scand. J. Prim. Health Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.amjmed.2018.01.022","article-title":"Dementia","volume":"131","author":"Gale","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000500040","article-title":"A mini-review of virtual reality-based interventions to promote well-being for people living with dementia and mild cognitive impairment","volume":"65","author":"Nguyen","year":"2019","journal-title":"Gerontology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1177\/1471301218813234","article-title":"Non-pharmacological interventions for people with dementia: A review of reviews","volume":"19","author":"Meyer","year":"2020","journal-title":"Dementia"},{"key":"ref_7","first-page":"116","article-title":"Non-Pharmacologic Interventions for Persons with Dementia","volume":"114","author":"Stewart","year":"2017","journal-title":"Mo. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3389\/fpsyg.2018.02086","article-title":"The Past, Present, and Future of Virtual and Augmented Reality Research: A Network and Cluster Analysis of the Literature","volume":"9","author":"Cipresso","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Parsons, T.D., Gaggioli, A., and Riva, G. (2020). Extended reality for the clinical, affective, and social neurosciences. Brain Sci., 10.","DOI":"10.3390\/brainsci10120922"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e30249","DOI":"10.2196\/30249","article-title":"Examining the Academic Trends in Neuropsychological Tests for Executive Functions Using Virtual Reality: Systematic Literature Review","volume":"9","author":"Kim","year":"2021","journal-title":"JMIR Serious Games"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1080\/13854040802360558","article-title":"Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults","volume":"23","author":"Harvey","year":"2009","journal-title":"Clin. Neuropsychol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnagi.2018.00088","article-title":"The Study of Evaluation and Rehabilitation of Patients With Different Cognitive Impairment Phases Based on Virtual Reality and EEG","volume":"10","author":"Wen","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"586999","DOI":"10.3389\/fnagi.2021.586999","article-title":"Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis","volume":"13","author":"Zhu","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.3389\/fpsyg.2019.01330","article-title":"Age-Related Differences With Immersive and Non-immersive Virtual Reality in Memory Assessment","volume":"10","author":"Sahula","year":"2019","journal-title":"Front. Psychol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.physio.2019.12.007","article-title":"Comparison of virtual reality rehabilitation and conventional rehabilitation in Parkinson\u2019s disease: A randomised controlled trial","volume":"106","author":"Pazzaglia","year":"2020","journal-title":"Physiotherapy"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bevilacqua, R., Maranesi, E., Riccardi, G.R., Di Donna, V., Pelliccioni, P., Luzi, R., Lattanzio, F., and Pelliccioni, G. (2019). Non-Immersive Virtual Reality for Rehabilitation of the Older People: A Systematic Review into Efficacy and Effectiveness. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111882"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-L\u00f3pez, H., Obrero-Gait\u00e1n, E., Castro-S\u00e1nchez, A.M., Lara-Palomo, I.C., Nieto-Escamez, F.A., and Cort\u00e9s-P\u00e9rez, I. (2021). Non-Immersive Virtual Reality to Improve Balance and Reduce Risk of Falls in People Diagnosed with Parkinson\u2019s Disease: A Systematic Review. Brain Sci., 11.","DOI":"10.3390\/brainsci11111435"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Maranesi, E., Casoni, E., Baldoni, R., Barboni, I., Rinaldi, N., Tramontana, B., Amabili, G., Benadduci, M., Barbarossa, F., and Luzi, R. (2022). The Effect of Non-Immersive Virtual Reality Exergames versus Traditional Physiotherapy in Parkinson\u2019s Disease Older Patients: Preliminary Results from a Randomized-Controlled Trial. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192214818"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"276734","DOI":"10.4061\/2011\/276734","article-title":"The Link between Cognitive Measures and ADLs and IADL Functioning in Mild Alzheimer\u2019s: What Has Gender Got to Do with It?","volume":"2011","author":"Hall","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_20","first-page":"CD010760","article-title":"Virtual reality for rehabilitation in Parkinson\u2019s disease","volume":"12","author":"Dockx","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10072-019-04144-3","article-title":"The role of virtual reality on outcomes in rehabilitation of Parkinson\u2019s disease: Meta-analysis and systematic review in 1031 participants","volume":"41","author":"Triegaardt","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0010-440X(03)00006-3","article-title":"Interactive computer-training as a therapeutic tool in Alzheimer\u2019s disease","volume":"44","author":"Hofmann","year":"2003","journal-title":"Compr. Psychiatry"},{"key":"ref_23","first-page":"415","article-title":"Involving persons with dementia in the evaluation of outdoor environments","volume":"11","author":"Martyr","year":"2008","journal-title":"Cyberpsychology Behav. Impact Internet Multimed. Virtual Real. Behav. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1162\/PRES_a_00080","article-title":"A Dual-Modal Virtual Reality Kitchen for (Re)Learning of Everyday Cooking Activities in Alzheimer\u2019s Disease","volume":"21","author":"Yamaguchi","year":"2012","journal-title":"Presence"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1017\/S1355617714000344","article-title":"Detecting everyday action deficits in Alzheimer\u2019s disease using a nonimmersive virtual reality kitchen","volume":"20","author":"Allain","year":"2014","journal-title":"J. Int. Neuropsychol. Soc. JINS"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnagi.2015.00024","article-title":"\u2018Kitchen and cooking\u2019, a serious game for mild cognitive impairment and Alzheimer\u2019s disease: A pilot study","volume":"7","author":"Manera","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_27","first-page":"42","article-title":"A pilot study and brief overview of rehabilitation via virtual environment in patients suffering from dementia","volume":"29","author":"Fasilis","year":"2018","journal-title":"Psychiatr. Psychiatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/09602011.2015.1094394","article-title":"The potential of virtual reality-based training to enhance the functional autonomy of Alzheimer\u2019s disease patients in cooking activities: A single case study","volume":"28","author":"Foloppe","year":"2018","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Panerai, S., Gelardi, D., Catania, V., Rundo, F., Tasca, D., Musso, S., Prestianni, G., Muratore, S., Babiloni, C., and Ferri, R. (2021). Functional Living Skills: A Non-Immersive Virtual Reality Training for Individuals with Major Neurocognitive Disorders. Sensors, 21.","DOI":"10.3390\/s21175751"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: Self maintaining and instrumental activity of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"J. Gerontol."},{"key":"ref_32","first-page":"625","article-title":"Occupational therapy practice framework: Domain & practice, 2nd edition","volume":"62","author":"Roley","year":"2008","journal-title":"Am. J. Occup. Ther. Off. Publ. Am. Occup. Ther. Assoc."},{"key":"ref_33","unstructured":"Cooper, J.O., Heron, T.E., and Heward, W.L. (2007). Applied Behavior Analysis, Pearson Prentice Hall. [2nd ed.]."},{"key":"ref_34","first-page":"237","article-title":"Non-pharmacological treatments for people with Major Neurocognitive Disorders: What suggestions from Applied Behavior Analysis? An overview","volume":"XXIV","author":"Panerai","year":"2021","journal-title":"Life Span Disabil."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40614-014-0006-1","article-title":"Gamification: The Intersection between Behavior Analysis and Game Design Technologies","volume":"37","author":"Morford","year":"2014","journal-title":"Behav. Anal."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Carnett, A., Neely, L., Gardiner, S., Kirpatrick, M., Quarles, J., and Christopher, K. (2022). Systematic Review of Virtual Reality in Behavioral Interventions for Individuals with Autism. Adv. Neurodev. Disord.","DOI":"10.1007\/s41252-022-00287-1"},{"key":"ref_37","first-page":"189","article-title":"Raven\u2019s Coloured Progressive Matrices: Normative values on 305 adult normal controls","volume":"2","author":"Basso","year":"1987","journal-title":"Funct. Neurol."},{"key":"ref_38","first-page":"345","article-title":"Erratum to: Forward and backward span for verbal and visuo-spatial data: Standardization and normative data from an Italian adult population","volume":"36","author":"Monaco","year":"2015","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000117297","article-title":"The Mental Deterioration Battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery","volume":"36","author":"Carlesimo","year":"1996","journal-title":"Eur. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: A Frontal Assessment Battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of Illness in the Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function","volume":"185","author":"Katz","year":"1963","journal-title":"JAMA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/17434440.2020.1825939","article-title":"Virtual reality in neurorehabilitation: A review of its effects on multiple cognitive domains","volume":"17","author":"Riva","year":"2020","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.apmr.2022.03.012","article-title":"Effects of Virtual Reality Rehabilitation Training on Cognitive Function and Activities of Daily Living of Patients with Poststroke Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"103","author":"Chen","year":"2022","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Oliveira, J., Gamito, P., Souto, T., Conde, R., Ferreira, M., Corotnean, T., Fernandes, A., Silva, H., and Neto, T. (2021). Virtual Reality-Based Cognitive Stimulation on People with Mild to Moderate Dementia due to Alzheimer\u2019s Disease: A Pilot Randomized Controlled Trial. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18105290"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1037\/0894-4105.11.4.514","article-title":"Fluency and memory differences between ischemic vascular dementia and Alzheimer\u2019s disease","volume":"11","author":"Lafosse","year":"1997","journal-title":"Neuropsychology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/13803390903418918","article-title":"Temporal order memory differences in Alzheimer\u2019s disease and vascular dementia","volume":"32","author":"Hampstead","year":"2010","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jns.2004.11.006","article-title":"Patterns of memory impairment and perseverative behavior discriminate early Alzheimer\u2019s disease from subcortical vascular dementia","volume":"229\u2013230","author":"Traykov","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jns.2009.02.377","article-title":"Prospective and retrospective memory in Alzheimer\u2019s disease and vascular dementia: Similar patterns of impairment","volume":"283","author":"Livner","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neubiorev.2020.05.018","article-title":"How brain imaging provides predictive biomarkers for therapeutic success in the context of virtual reality cognitive training","volume":"120","author":"Ansado","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"784054","DOI":"10.3389\/fnagi.2021.784054","article-title":"Effects of Cognitive Reserve in Alzheimer\u2019s Disease and Cognitively Unimpaired Individuals","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13195-018-0422-7","article-title":"Vulnerability and resilience to Alzheimer\u2019s disease: Early life conditions modulate neuropathology and determine cognitive reserve","volume":"10","author":"Lesuis","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fnagi.2016.00084","article-title":"Cognitive Reserve in Dementia: Implications for Cognitive Training","volume":"8","author":"Mondini","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_53","unstructured":"Kahneman, D. (2011). Thinking, Fast and Slow, Farrar, Straus & Giroux."},{"key":"ref_54","unstructured":"Riva, G. (2021, August 06). Neuroscience of Virtual Reality and Behavioral Change. Available online: https:\/\/www.slideshare.net\/bepperiva\/neuroscience-of-virtual-reality-and-behavioral-change-giuseppe-riva-phd."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.trci.2019.09.016","article-title":"A systematic review of the use of virtual reality and its effects on cognition in individuals with neurocognitive disorders. Alzheimer\u2019s Dement","volume":"5","author":"Moreno","year":"2019","journal-title":"Transl. Res. Clin. Interv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1755-5949.2009.00132.x","article-title":"Review: Apathy diagnosis, assessment, and treatment in Alzheimer\u2019s disease","volume":"16","author":"Robert","year":"2010","journal-title":"CNS Neurosci. Ther."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/4\/1896\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:27:57Z","timestamp":1760120877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/4\/1896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["s23041896"],"URL":"https:\/\/doi.org\/10.3390\/s23041896","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]}}}