{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T21:15:36Z","timestamp":1769980536646,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Structural and Investment Funds","award":["KK.01.1.1.01.0010"],"award-info":[{"award-number":["KK.01.1.1.01.0010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Promethazine hydrochloride (PM) is a widely used drug so its determination is important. Solid-contact potentiometric sensors could be an appropriate solution for that purpose due to their analytical properties. The aim of this research was to develop solid-contact sensor for potentiometric determination of PM. It had a liquid membrane containing hybrid sensing material based on functionalized carbon nanomaterials and PM ions. The membrane composition for the new PM sensor was optimized by varying different membrane plasticizers and the content of the sensing material. The plasticizer was selected based on calculations of Hansen solubility parameters (HSP) and experimental data. The best analytical performances were obtained using a sensor with 2-nitrophenyl phenyl ether (NPPE) as the plasticizer and 4% of the sensing material. It had a Nernstian slope (59.4 mV\/decade of activity), a wide working range (6.2 \u00d7 10\u22127 M\u20135.0 \u00d7 10\u22123 M), a low limit of detection (1.5 \u00d7 10\u22127 M), fast response time (6 s), low signal drift (\u22121.2 mV\/h), and good selectivity. The working pH range of the sensor was between 2 and 7. The new PM sensor was successfully used for accurate PM determination in a pure aqueous PM solution and pharmaceutical products. For that purpose, the Gran method and potentiometric titration were used.<\/jats:p>","DOI":"10.3390\/s23052641","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T02:01:51Z","timestamp":1677549711000},"page":"2641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development of the New Sensor Based on Functionalized Carbon Nanomaterials for Promethazine Hydrochloride Determination"],"prefix":"10.3390","volume":"23","author":[{"given":"Mirela","family":"Samard\u017ei\u0107","sequence":"first","affiliation":[{"name":"Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8\/A, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Per\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8\/A, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9207-2551","authenticated-orcid":false,"given":"Aleksandar","family":"Sz\u00e9chenyi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8\/A, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-8105","authenticated-orcid":false,"given":"Marija","family":"Jozanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8\/A, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Pukle\u0161","sequence":"additional","affiliation":[{"name":"Doctoral School of Chemistry, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Budeti\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8\/A, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"161768","DOI":"10.1016\/j.jallcom.2021.161768","article-title":"Morphological Evolution of Nanosheets-Stacked Spherical ZnO for Preparation of GO-Zn\/ZnO Ternary Nanocomposite: A Novel Electrochemical Platform for Nanomolar Detection of Antihistamine Promethazine Hydrochloride","volume":"890","author":"Sebastian","year":"2022","journal-title":"J. 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