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From these signals, one can non-invasively derive the dynamics of brain activity. Conventional MEG systems (SQUID-MEG) use very low temperatures to achieve the necessary sensitivity. This leads to severe experimental and economical limitations. A new generation of MEG sensors is emerging: the optically pumped magnetometers (OPM). In OPM, an atomic gas enclosed in a glass cell is traversed by a laser beam whose modulation depends on the local magnetic field. MAG4Health is developing OPMs using Helium gas (4He-OPM). They operate at room temperature with a large dynamic range and a large frequency bandwidth and output natively a 3D vectorial measure of the magnetic field. In this study, five 4He-OPMs were compared to a classical SQUID-MEG system in a group of 18 volunteers to evaluate their experimental performances. Considering that the 4He-OPMs operate at real room temperature and can be placed directly on the head, our assumption was that 4He-OPMs would provide a reliable recording of physiological magnetic brain activity. Indeed, the results showed that the 4He-OPMs showed very similar results to the classical SQUID-MEG system by taking advantage of a shorter distance to the brain, despite having a lower sensitivity.<\/jats:p>","DOI":"10.3390\/s23052801","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T02:28:34Z","timestamp":1678069714000},"page":"2801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A New Generation of OPM for High Dynamic and Large Bandwidth MEG: The 4He OPMs\u2014First Applications in Healthy Volunteers"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-418X","authenticated-orcid":false,"given":"Tjerk","family":"Gutteling","sequence":"first","affiliation":[{"name":"CERMEP-Imagerie du Vivant, MEG Departement, 69000 Lyon, France"},{"name":"CRNL, UMR_S 1028, HCL, Universit\u00e9 Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bonnefond","sequence":"additional","affiliation":[{"name":"CRNL, UMR_S 1028, HCL, Universit\u00e9 Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Clausner","sequence":"additional","affiliation":[{"name":"CRNL, UMR_S 1028, HCL, Universit\u00e9 Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Daligault","sequence":"additional","affiliation":[{"name":"CERMEP-Imagerie du Vivant, MEG Departement, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-8096","authenticated-orcid":false,"given":"Rudy","family":"Romain","sequence":"additional","affiliation":[{"name":"MAG<sup>4<\/sup>Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Mitryukovskiy","sequence":"additional","affiliation":[{"name":"MAG<sup>4<\/sup>Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fourcault","sequence":"additional","affiliation":[{"name":"CEA LETI, Minatec Campus, Universit\u00e9 Grenoble Alpes, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Josselin","sequence":"additional","affiliation":[{"name":"CEA LETI, Minatec Campus, Universit\u00e9 Grenoble Alpes, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Le Prado","sequence":"additional","affiliation":[{"name":"MAG<sup>4<\/sup>Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-3317","authenticated-orcid":false,"given":"Agustin","family":"Palacios-Laloy","sequence":"additional","affiliation":[{"name":"MAG<sup>4<\/sup>Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-7213","authenticated-orcid":false,"given":"Etienne","family":"Labyt","sequence":"additional","affiliation":[{"name":"MAG<sup>4<\/sup>Health, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Jung","sequence":"additional","affiliation":[{"name":"CRNL, UMR_S 1028, HCL, Universit\u00e9 Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-2934","authenticated-orcid":false,"given":"Denis","family":"Schwartz","sequence":"additional","affiliation":[{"name":"CERMEP-Imagerie du Vivant, MEG Departement, 69000 Lyon, France"},{"name":"CRNL, UMR_S 1028, HCL, Universit\u00e9 Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nn.4504","article-title":"Magnetoencephalography for Brain Electrophysiology and Imaging","volume":"20","author":"Baillet","year":"2017","journal-title":"Nat. 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