{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:08:30Z","timestamp":1773868110097,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg\/dL to 11.4 mg\/dL. The detection limit was 0.125 mM (or 2.3 mg\/dL), much lower than the hypoglycemia level of 70 mg\/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors\u2019 efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment.<\/jats:p>","DOI":"10.3390\/s23052841","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T02:28:34Z","timestamp":1678069714000},"page":"2841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-9166","authenticated-orcid":false,"given":"Son Hai","family":"Nguyen","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Hanoi University of Science and Technology, Hanoi 100000, Vietnam"}]},{"given":"Phan Kim Thi","family":"Vu","sequence":"additional","affiliation":[{"name":"College of Engineering and Computer Science, VinUniversity, Hanoi 100000, Vietnam"}]},{"given":"Hung Manh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"College of Engineering and Computer Science, VinUniversity, Hanoi 100000, Vietnam"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7993-5735","authenticated-orcid":false,"given":"Mai Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"College of Engineering and Computer Science, VinUniversity, Hanoi 100000, Vietnam"},{"name":"VinUni-Illinois Smart Health Center, VinUniversity, Hanoi 100000, Vietnam"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4093\/dmj.2012.36.5.336","article-title":"Management of type 2 diabetes mellitus in older adults","volume":"36","author":"Kim","year":"2012","journal-title":"Diabetes Metab. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.3390\/s100504558","article-title":"Glucose biosensors: An overview of use in clinical practice","volume":"10","author":"Yoo","year":"2010","journal-title":"Sensors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.sbsr.2015.02.002","article-title":"Noninvasive glucose monitoring using saliva nano-biosensor","volume":"4","author":"Zhang","year":"2015","journal-title":"Sens. Bio-Sens. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1039\/C8AY02177E","article-title":"Visual detection of glucose based on quantum dots aerogel in microfluidic chips","volume":"10","author":"Hu","year":"2018","journal-title":"Anal. Methods"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100121","DOI":"10.1016\/j.sintl.2021.100121","article-title":"Sensors for daily life: A review","volume":"2","author":"Javaid","year":"2021","journal-title":"Sensors Int."},{"key":"ref_6","unstructured":"Nayak, M.K., Singh, J., Singh, B., Soni, S., Pandey, V.S., and Tyagi, S. (2017). Metal Semiconductor Core-Shell Nanostructures for Energy and Environmental Applications, Elsevier."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1136\/bmj.319.7220.1288","article-title":"Sensors in medicine","volume":"319","author":"Wilson","year":"1999","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1002\/smll.201300635","article-title":"Tuning the emission colors of semiconductor nanocrystals beyond their bandgap tunability: All in the dope","volume":"9","author":"Jana","year":"2013","journal-title":"Small"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/nl047996m","article-title":"Cytotoxicity of colloidal CdSe and CdSe\/ZnS nanoparticles","volume":"5","author":"Kirchner","year":"2005","journal-title":"Nano Lett."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bykkam, S., Prasad, D., Maurya, M.R., Sadasivuni, K.K., and Cabibihan, J.J. (2021). Comparison study of metal oxides (CeO2, CuO, SnO2, CdO, ZnO and TiO2) decked few layered graphene nanocomposites for Dye-Sensitized solar cells. Sustainability, 13.","DOI":"10.3390\/su13147685"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1039\/b820112a","article-title":"Competitive analysis of saccharides or dopamine by boronic acid-functionalized CdSe\u2013ZnS quantum dots","volume":"7","author":"Freeman","year":"2009","journal-title":"Chem. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"022004","DOI":"10.1088\/2516-1091\/abe6f8","article-title":"Optical sensors for continuous glucose monitoring","volume":"3","author":"Yu","year":"2021","journal-title":"Prog. Biomed. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.mssp.2015.05.017","article-title":"Chemical bath deposition of Fe-doped ZnS thin films: Investigations of their ferromagnetic and half-metallic properties","volume":"39","author":"Akhtar","year":"2015","journal-title":"Mater. Sci. Semicond. Process."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-9-20","article-title":"Tunable blue-green-emitting wurtzite ZnS: Mg nanosheet-assembled hierarchical spheres for near-UV white LEDs","volume":"9","author":"Reddy","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"126481","DOI":"10.1016\/j.matchemphys.2022.126481","article-title":"The effect of deposition time on the growth and properties of cupper doped zinc sulfide thin films deposited via spray pyrolysis","volume":"290","author":"Najim","year":"2022","journal-title":"Mater. Chem. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijleo.2016.10.083","article-title":"Chemical bath deposition of Mn-doped ZnS thin films using greener complexing agents: Effect of Mn-doping on the optical properties","volume":"130","author":"Pejjai","year":"2017","journal-title":"Optik"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"012183","DOI":"10.1063\/1.3698310","article-title":"Tunable emission in surface passivated Mn-ZnS nanophosphors and its application for Glucose sensing","volume":"2","author":"Sharma","year":"2012","journal-title":"AIP Adv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1088\/0957-4484\/17\/1\/022","article-title":"Synthesis and characterization of monodisperse chitosan nanoparticles with embedded quantum dots","volume":"17","author":"Nie","year":"2005","journal-title":"Nanotechnology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6544","DOI":"10.1021\/jp034476r","article-title":"Full-Color Emission and Temperature Dependence of the Luminescence in Poly-P-phenylene ethynylene- ZnS\/Mn2+ Composite Particles","volume":"107","author":"Chen","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.biotechadv.2009.04.003","article-title":"Glucose oxidase\u2014An overview","volume":"27","author":"Bankar","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1007\/s00216-016-9849-5","article-title":"Glucose oxidase probe as a surface-enhanced Raman scattering sensor for glucose","volume":"408","author":"Qi","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s13206-016-1107-6","article-title":"Glucose detection using 4-mercaptophenyl boronic acid-incorporated silver nanoparticles-embedded silica-coated graphene oxide as a SERS substrate","volume":"11","author":"Pham","year":"2017","journal-title":"BioChip J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bios.2019.05.002","article-title":"Hydrogel optical fibers for continuous glucose monitoring","volume":"137","author":"Elsherif","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105010","DOI":"10.1016\/j.microc.2020.105010","article-title":"Highly-sensitive and reflective glucose sensor based on optical fiber surface plasmon resonance","volume":"157","author":"Zheng","year":"2020","journal-title":"Microchem. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12034-016-1178-y","article-title":"Chitosan-encapsulated ZnS: M (M: Fe3+ or Mn2+) quantum dots for fluorescent labelling of sulphate-reducing bacteria","volume":"39","author":"Raghuram","year":"2016","journal-title":"Bull. Mater. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"62193","DOI":"10.1039\/C6RA09702B","article-title":"Room-temperature phosphorescence probe based on Mn-doped ZnS quantum dots for the sensitive and selective detection of selenite","volume":"6","author":"Chen","year":"2016","journal-title":"RSC Adv."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/5\/2841\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:35Z","timestamp":1760122115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/5\/2841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["s23052841"],"URL":"https:\/\/doi.org\/10.3390\/s23052841","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]}}}