{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:25:48Z","timestamp":1778685948470,"version":"3.51.4"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["61761013"],"award-info":[{"award-number":["61761013"]}]},{"name":"National Natural Science Foundation of China","award":["61864001"],"award-info":[{"award-number":["61864001"]}]},{"name":"National Natural Science Foundation of China","award":["2017GXNSFAA198116"],"award-info":[{"award-number":["2017GXNSFAA198116"]}]},{"name":"National Natural Science Foundation of China","award":["YQ17113"],"award-info":[{"award-number":["YQ17113"]}]},{"name":"Natural Science Foundation of Guangxi Province","award":["61761013"],"award-info":[{"award-number":["61761013"]}]},{"name":"Natural Science Foundation of Guangxi Province","award":["61864001"],"award-info":[{"award-number":["61864001"]}]},{"name":"Natural Science Foundation of Guangxi Province","award":["2017GXNSFAA198116"],"award-info":[{"award-number":["2017GXNSFAA198116"]}]},{"name":"Natural Science Foundation of Guangxi Province","award":["YQ17113"],"award-info":[{"award-number":["YQ17113"]}]},{"name":"Guangxi Key Laboratory of Automatic Detection Technology and Instruments Foundation Project","award":["61761013"],"award-info":[{"award-number":["61761013"]}]},{"name":"Guangxi Key Laboratory of Automatic Detection Technology and Instruments Foundation Project","award":["61864001"],"award-info":[{"award-number":["61864001"]}]},{"name":"Guangxi Key Laboratory of Automatic Detection Technology and Instruments Foundation Project","award":["2017GXNSFAA198116"],"award-info":[{"award-number":["2017GXNSFAA198116"]}]},{"name":"Guangxi Key Laboratory of Automatic Detection Technology and Instruments Foundation Project","award":["YQ17113"],"award-info":[{"award-number":["YQ17113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>As an essential indicator of liver function, bilirubin is of great significance for clinical diagnosis. A non-enzymatic sensor has been established for sensitive bilirubin detection based on the bilirubin oxidation catalyzed by unlabeled gold nanocages (GNCs). GNCs with dual-localized surface plasmon resonance (LSPR) peaks were prepared by a one-pot method. One peak around 500 nm was ascribed to gold nanoparticles (AuNPs), and the other located in the near-infrared region was the typical peak of GNCs. The catalytic oxidation of bilirubin by GNCs was accompanied by the disruption of cage structure, releasing free AuNPs from the nanocage. This transformation changed the dual peak intensities in opposite trend, and made it possible to realize the colorimetric sensing of bilirubin in a ratiometric mode. The absorbance ratios showed good linearity to bilirubin concentrations in the range of 0.20~3.60 \u03bcmol\/L with a detection limit of 39.35 nM (3\u03c3, n = 3). The sensor exhibited excellent selectivity for bilirubin over other coexisting substances. Bilirubin in real human serum samples was detected with recoveries ranging from 94.5 to 102.6%. The method for bilirubin assay is simple, sensitive and without complex biolabeling.<\/jats:p>","DOI":"10.3390\/s23062969","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T03:46:40Z","timestamp":1678333600000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non-Enzymatically Colorimetric Bilirubin Sensing Based on the Catalytic Structure Disruption of Gold Nanocages"],"prefix":"10.3390","volume":"23","author":[{"given":"Wenxiang","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"},{"name":"Guangxi Colleges and Universities Key Laboratory of Biomedical Sensing and Intelligent Instrument, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinan","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoxin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhencheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"},{"name":"Guangxi Colleges and Universities Key Laboratory of Biomedical Sensing and Intelligent Instrument, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-9392","authenticated-orcid":false,"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"},{"name":"Guangxi Colleges and Universities Key Laboratory of Biomedical Sensing and Intelligent Instrument, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.siny.2009.10.005","article-title":"Controversies in bilirubin biochemistry and their clinical relevance","volume":"15","author":"McDonagh","year":"2010","journal-title":"Semin. 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