{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:41:42Z","timestamp":1769971302129,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Physical and Rehabilitation Medicine Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Two-thirds of people with Multiple Sclerosis (PwMS) have walking disabilities. Considering the literature, prolonged tests, such as the 6 min walk test, better reflect their everyday life walking capacities and endurance. However, in most studies, only the distance traveled during the 6MWT was measured. This study aims to analyze spatio-temporal (ST) walking patterns of PwMS and healthy people in the 6MWT. Participants performed a 6MWT with measures of five ST variables during three 1 min intervals (initial: 0\u2032\u20131\u2032, middle: 2\u203230\u2033\u20133\u203230\u2033, end: 5\u2032\u20136\u2032) of the 6MWT, using the GAITRite system. Forty-five PwMS and 24 healthy people were included. We observed in PwMS significant changes between initial and final intervals for all ST parameters, whereas healthy people had a rebound pattern but the changes between intervals were rather negligible. Moreover, ST variables\u2019 changes were superior to the standard measurement error only for PwMS between initial and final intervals for all ST parameters. This result suggests that the modification in PwMS\u2019 walking pattern is effectively due to their walking ability and not to a measurement, and suggests that PwMS could not manage their walking efficiently compared to healthy people, who could maintain their rhythm throughout the 6MWT. Further studies are needed to detect these patterns changes in the early evolution of the disease, identify clinical determinants involved in PwMS\u2019 walking pattern, and investigate whether interventions can positively impact this pattern.<\/jats:p>","DOI":"10.3390\/s23073407","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T03:16:46Z","timestamp":1679627806000},"page":"3407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Locomotor Strategy to Perform 6-Minute Walk Test in People with Multiple Sclerosis: A Prospective Observational Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-5593","authenticated-orcid":false,"given":"Nawale","family":"Hadouiri","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"Clinical Investigation Center, INSERM 1431, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"Department of Physical Medicine and Rehabilitation, Dijon-Bourgogne University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-2579","authenticated-orcid":false,"given":"Elisabeth","family":"Monnet","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, INSERM 1431, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"EA4266 Agents Pathog\u00e8nes et Inflammation, University of Bourgogne-Franche-Comte, 25000 Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-8448","authenticated-orcid":false,"given":"Arnaud","family":"Gouelle","sequence":"additional","affiliation":[{"name":"Laboratory Performance, Sant\u00e9, M\u00e9trologie, Soci\u00e9t\u00e9 (PSMS), UFR STAPS, 51000 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-3095","authenticated-orcid":false,"suffix":"Jr.","given":"Yoshimasa","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"Clinical Investigation Center, INSERM 1431, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-7171","authenticated-orcid":false,"given":"Pierre","family":"Decavel","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"},{"name":"Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, 25000 Besan\u00e7on, France"},{"name":"Rehabilitation Department, HFR, 1700 Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","first-page":"359","article-title":"What Do We Know of Multiple Sclerosis?","volume":"66","author":"Reese","year":"1946","journal-title":"J. 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