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However, strict requirements of a single sensor on the arterial position make it difficult to meet the practical application scenarios. Herein, based on three single-electrode sensors with small area, a 3 \u00d7 1 flexible pressure sensor array was developed to enable measurement of epidermal pulse waves at different local positions of radial artery. The designed single sensor holds an area of 6 \u00d7 6 mm2, which mainly consists of frosted microstructured Ecoflex film and thermoplastic polyurethane (TPU) nanofibers. The Ecoflex film was formed by spinning Ecoflex solution onto a sandpaper surface. Micropatterned TPU nanofibers were prepared on a fluorinated ethylene propylene (FEP) film surface using the electrospinning method. The combination of frosted microstructure and nanofibers provides an increase in the contact separation of the tribopair, which is of great benefit for improving sensor performance. Due to this structure design, the single small-area sensor was characterized by pressure sensitivity of 0.14 V\/kPa, a response time of 22 ms, a wide frequency band ranging from 1 to 23 Hz, and stability up to 7000 cycles. Given this output performance, the fabricated sensor can detect subtle physiological signals (e.g., respiration, ballistocardiogram, and heartbeat) and body movement. More importantly, the sensor can be utilized in capturing human epidermal pulse waves with rich details, and the consistency of each cycle in the same measurement is as high as 0.9987. The 3 \u00d7 1 flexible sensor array is employed to acquire pulse waves at different local positions of the radial artery. In addition, the time domain parameters including pulse wave transmission time (PTT) and pulse wave velocity (PWV) can be obtained successfully, which holds promising potential in pulse-based cardiovascular system status monitoring.<\/jats:p>","DOI":"10.3390\/s23073717","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T02:03:00Z","timestamp":1680573780000},"page":"3717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Flexible Sensors Array Based on Frosted Microstructured Ecoflex Film and TPU Nanofibers for Epidermal Pulse Wave Monitoring"],"prefix":"10.3390","volume":"23","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"given":"Zhiping","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"given":"Gaoqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"given":"Luna","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China"},{"name":"Key Laboratory of Optoelectronic Technology and Systems Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-0380","authenticated-orcid":false,"given":"Zhonglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/MAJ.0000000000000285","article-title":"Relation of arterial stiffness assessed by brachial-ankle pulse wave velocity to complexity of coronary artery disease","volume":"348","author":"Chung","year":"2014","journal-title":"Am. 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