{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:02:23Z","timestamp":1760148143342,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Korean government (MSIT)","doi-asserted-by":"publisher","award":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"],"award-info":[{"award-number":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brain Korea 21","award":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"],"award-info":[{"award-number":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"]}]},{"name":"Ministry of Education (MOE)","award":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"],"award-info":[{"award-number":["2022R1A2C1010151","2022R1C1C1011328","2022H1D3A2A02081592","2022RIS-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Pulse oximetry is a non-invasive method for measuring blood oxygen saturation. However, its detection scheme heavily relies on single-point measurements. If the oxygen saturation is measured at a single location, the measurements are influenced by the profile of illumination, spatial variations in blood flow, and skin pigment. To overcome these issues, imaging systems that measure the distribution of oxygen saturation have been demonstrated. However, previous imaging systems have relied on red and near-infrared illuminations with different profiles, resulting in inconsistent ratios between transmitted red and near-infrared light over space. Such inconsistent ratios can introduce fundamental errors when calculating the spatial distribution of oxygen saturation. In this study, we developed a novel illumination system specifically designed for a pulse oximetry imaging system. For the illumination system, we customized the integrating sphere by coating a mixture of barium sulfate and white paint inside it and by coupling eight red and eight near-infrared LEDs. The illumination system created identical patterns of red and near-infrared illuminations that were spatially uniform. This allowed the ratio between transmitted red and near-infrared light to be consistent over space, enabling the calculation of the spatial distribution of oxygen saturation. We believe our developed pulse oximetry imaging system can be used to obtain spatial information on blood oxygen saturation that provides insight into the oxygenation of the blood contained within the peripheral region of the tissue.<\/jats:p>","DOI":"10.3390\/s23073723","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T04:09:50Z","timestamp":1680581390000},"page":"3723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulse Oximetry Imaging System Using Spatially Uniform Dual Wavelength Illumination"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-7114","authenticated-orcid":false,"given":"Riaz","family":"Muhammad","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"}]},{"given":"Kay Thwe","family":"Htun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"}]},{"given":"Ezekiel Edward","family":"Nettey-Oppong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-7258","authenticated-orcid":false,"given":"Ahmed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"},{"name":"Department of Electrical Engineering, Sukkur IBA University, Sukkur 65200, Pakistan"}]},{"given":"Dae Keun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Mediana, R&D Center, Wonju 26365, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-1231","authenticated-orcid":false,"given":"Hyun-Woo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Eulji University, Seongnam 13135, Republic of Korea"}]},{"given":"Kyung Min","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Republic of Korea"},{"name":"Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin 17104, Republic of Korea"}]},{"given":"Seung Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"},{"name":"Department of Integrative Medicine, Major in Digital Healthcare, Yonsei University College of Medicine, Seoul 06229, Republic of Korea"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/cts.12874","article-title":"An evaluation of biometric monitoring technologies for vital signs in the era of COVID-19","volume":"13","author":"Manta","year":"2020","journal-title":"Clin. 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