{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:45:27Z","timestamp":1778190327060,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) has become the second most common neurodegenerative condition following Alzheimer\u2019s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in the best case scenario, expert neurologists evaluate disease progression using established rating scales and patient-reported questionnaires, which have interpretability issues and are subject to recall bias. In this context, artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and support physicians to manage PD more effectively by monitoring patients in their familiar environment in an objective manner. In this study, we evaluate the validity of in-office clinical assessment using the MDS-UPDRS rating scale compared to home monitoring. Elaborating the results for 20 patients with Parkinson\u2019s disease, we observed moderate to strong correlations for most symptoms (bradykinesia, rest tremor, gait impairment, and freezing of gait), as well as for fluctuating conditions (dyskinesia and OFF). In addition, we identified for the first time the existence of an index capable of remotely measuring patients\u2019 quality of life. In summary, an in-office examination is only partially representative of most PD symptoms and cannot accurately capture daytime fluctuations and patients\u2019 quality of life.<\/jats:p>","DOI":"10.3390\/s23083807","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T03:24:18Z","timestamp":1681097058000},"page":"3807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical Evaluation in Parkinson\u2019s Disease: Is the Golden Standard Shiny Enough?"],"prefix":"10.3390","volume":"23","author":[{"given":"Foivos S.","family":"Kanellos","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"},{"name":"PD Neurotechnology Ltd., 45500 Ioannina, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-1630","authenticated-orcid":false,"given":"Konstantinos I.","family":"Tsamis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"},{"name":"Department of Neurology, University Hospital of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Georgios","family":"Rigas","sequence":"additional","affiliation":[{"name":"PD Neurotechnology Ltd., 45500 Ioannina, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-8906","authenticated-orcid":false,"given":"Yannis V.","family":"Simos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-6708","authenticated-orcid":false,"given":"Andreas P.","family":"Katsenos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Gerasimos","family":"Kartsakalis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-5082","authenticated-orcid":false,"given":"Dimitrios I.","family":"Fotiadis","sequence":"additional","affiliation":[{"name":"Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Patra","family":"Vezyraki","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Dimitrios","family":"Peschos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}]},{"given":"Spyridon","family":"Konitsiotis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Ioannina, 45110 Ioannina, Greece"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. 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