{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:12:36Z","timestamp":1761491556465,"version":"build-2065373602"},"reference-count":74,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG17917","R01AG56352","R01AG75728","K01AG054700","RF1AG59867","RF1AG64312","R01AG79133","A202886"],"award-info":[{"award-number":["R01AG17917","R01AG56352","R01AG75728","K01AG054700","RF1AG59867","RF1AG64312","R01AG79133","A202886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bright Focus","award":["R01AG17917","R01AG56352","R01AG75728","K01AG054700","RF1AG59867","RF1AG64312","R01AG79133","A202886"],"award-info":[{"award-number":["R01AG17917","R01AG56352","R01AG75728","K01AG054700","RF1AG59867","RF1AG64312","R01AG79133","A202886"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This study characterized person-specific rates of change of total daily physical activity (TDPA) and identified correlates of this change. TDPA metrics were extracted from multiday wrist-sensor recordings from 1083 older adults (average age 81 years; 76% female). Thirty-two covariates were collected at baseline. A series of linear mixed-effect models were used to identify covariates independently associated with the level and annual rate of change of TDPA. Though, person-specific rates of change varied during a mean follow-up of 5 years, 1079 of 1083 showed declining TDPA. The average decline was 16%\/year, with a 4% increased rate of decline for every 10 years of age older at baseline. Following variable selection using multivariate modeling with forward and then backward elimination, age, sex, education, and 3 of 27 non-demographic covariates including motor abilities, a fractal metric, and IADL disability remained significantly associated with declining TDPA accounting for 21% of its variance (9% non-demographic and 12% demographics covariates). These results show that declining TDPA occurs in many very old adults. Few covariates remained correlated with this decline and the majority of its variance remained unexplained. Further work is needed to elucidate the biology underlying TDPA and to identify other factors that account for its decline.<\/jats:p>","DOI":"10.3390\/s23084152","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T03:01:48Z","timestamp":1682046108000},"page":"4152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2742","authenticated-orcid":false,"given":"Aron S.","family":"Buchman","sequence":"first","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"given":"Tianhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"given":"Shahram","family":"Oveisgharan","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"given":"Andrea R.","family":"Zammit","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-3132","authenticated-orcid":false,"given":"Kun","family":"Hu","sequence":"additional","affiliation":[{"name":"Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-0776","authenticated-orcid":false,"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA"},{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6492416, Israel"},{"name":"Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}]},{"given":"Andrew S. P.","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","unstructured":"Administration on Aging (2016). Services USDoHaH, Department of Health and Human Services."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00415-022-11454-8","article-title":"Effects of physical activity and exercise interventions on Alzheimer\u2019s disease: An umbrella review of existing meta-analyses","volume":"270","author":"Lista","year":"2023","journal-title":"J. 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