{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:06:55Z","timestamp":1770224815258,"version":"3.49.0"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-71-10120"],"award-info":[{"award-number":["22-71-10120"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Recently, a new kind of sensor applicable in magnetoencephalography (MEG) has been presented: a solid-state yttrium-iron garnet magnetometer (YIGM). The feasibility of yttrium-iron garnet magnetometers (YIGMs) was demonstrated in an alpha-rhythm registration experiment. In this paper, we propose the analysis of lead-field matrices for different possible multi-channel on-scalp sensor layouts using YIGMs with respect to information theory. Real noise levels of the new sensor were used to compute signal-to-noise ratio (SNR) and total information capacity (TiC), and compared with corresponding metrics that can be obtained with well-established MEG systems based on superconducting quantum interference devices (SQUIDs) and optically pumped magnetometers (OPMs). The results showed that due to YIGMs\u2019 proximity to the subject\u2019s scalp, they outperform SQUIDs and OPMs at their respective noise levels in terms of SNR and TiC. However, the current noise levels of YIGM sensors are unfortunately insufficient for constructing a multichannel YIG-MEG system. This simulation study provides insight into the direction for further development of YIGM sensors to create a multi-channel MEG system, namely, by decreasing the noise levels of sensors.<\/jats:p>","DOI":"10.3390\/s23094256","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T04:27:02Z","timestamp":1682396822000},"page":"4256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Yttrium-Iron Garnet Magnetometer in MEG: Advance towards Multi-Channel Arrays"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-2436","authenticated-orcid":false,"given":"Ekaterina","family":"Skidchenko","sequence":"first","affiliation":[{"name":"CNBR, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia"}]},{"given":"Anna","family":"Butorina","sequence":"additional","affiliation":[{"name":"CNBR, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia"}]},{"given":"Maxim","family":"Ostras","sequence":"additional","affiliation":[{"name":"M-Granat, Russian Quantum Center, 121205 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-1850","authenticated-orcid":false,"given":"Petr","family":"Vetoshko","sequence":"additional","affiliation":[{"name":"M-Granat, Russian Quantum Center, 121205 Moscow, Russia"},{"name":"Laboratory of Magnetic Phenomena in Microelectronics, Kotelnikov Institute of Radioengineering and Electronics of RAS, 125009 Moscow, Russia"}]},{"given":"Alexey","family":"Kuzmichev","sequence":"additional","affiliation":[{"name":"M-Granat, Russian Quantum Center, 121205 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-7710","authenticated-orcid":false,"given":"Nikolay","family":"Yavich","sequence":"additional","affiliation":[{"name":"CNBR, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia"},{"name":"Computational Geophysics Lab, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia"}]},{"given":"Mikhail","family":"Malovichko","sequence":"additional","affiliation":[{"name":"Computational Geophysics Lab, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia"}]},{"given":"Nikolay","family":"Koshev","sequence":"additional","affiliation":[{"name":"CNBR, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.175.4022.664","article-title":"Magnetoencephalography: Detection of the brain\u2019s electrical activity with a superconducting magnetometer","volume":"175","author":"Cohen","year":"1972","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.neuroimage.2016.12.048","article-title":"Measuring MEG closer to the brain: Performance of on-scalp sensor arrays","volume":"147","author":"Iivanainen","year":"2017","journal-title":"NeuroImage"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"083001","DOI":"10.1088\/1361-6668\/aa73ad","article-title":"High-tc SQUID biomagnetometers","volume":"30","author":"Faley","year":"2017","journal-title":"Supercond. Sci. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Andersen, L.M., Oostenveld, R., Pfeiffer, C., Ruffieux, S., Jousm\u00e4ki, V., H\u00e4m\u00e4l\u00e4inen, M., Schneiderman, J.F., and Lundqvist, D. (2017). Similarities and differences between on-scalp and conventional in-helmet magnetoencephalography recordings. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178602"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"117157","DOI":"10.1016\/j.neuroimage.2020.117157","article-title":"On-scalp MEG SQUIDs are sensitive to early somatosensory activity unseen by conventional MEG","volume":"221","author":"Andersen","year":"2020","journal-title":"NeuroImage"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Schwindt, P.D., and Johnson, C.N. (2010). Atomic Magnetometer for Human Magnetoencephalography, Sandia Report SAND2010-8443.","DOI":"10.2172\/1011666"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1088\/1361-6560\/aa93d1","article-title":"A 20-channel magnetoencephalography system based on optically pumped magnetometers","volume":"62","author":"Borna","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuroimage.2017.01.034","article-title":"A new generation of magnetoencephalography: Room temperature measurements using optically pumped magnetometers","volume":"149","author":"Boto","year":"2017","journal-title":"NeuroImage"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1113\/JP277899","article-title":"Using optically pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum","volume":"597","author":"Lin","year":"2019","journal-title":"J. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature26147","article-title":"Moving magnetoencephalography towards real-world applications with a wearable system","volume":"555","author":"Boto","year":"2018","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Borna, A., Carter, T.R., Colombo, A.P., Jau, Y.Y., McKay, J., Weisend, M., Taulu, S., Stephen, J.M., and Schwindt, P.D. (2020). Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227684"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143501","DOI":"10.1063\/5.0004746","article-title":"Portable intrinsic gradiometer for ultra-sensitive detection of magnetic gradient in unshielded environment","volume":"116","author":"Zhang","year":"2020","journal-title":"Appl. Phys. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116995","DOI":"10.1016\/j.neuroimage.2020.116995","article-title":"Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system","volume":"219","author":"Hill","year":"2020","journal-title":"NeuroImage"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"011002","DOI":"10.1103\/PhysRevApplied.14.011002","article-title":"Portable magnetometry for detection of biomagnetism in ambient environments","volume":"14","author":"Limes","year":"2020","journal-title":"Phys. Rev. Appl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18626","DOI":"10.1109\/JSEN.2021.3089455","article-title":"Towards the non-zero field cesium magnetic sensor array for magnetoencephalography","volume":"21","author":"Petrenko","year":"2021","journal-title":"IEEE Sens. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1038\/s41598-017-07046-6","article-title":"Evaluation of realistic layouts for next generation on-scalp MEG: Spatial information density maps","volume":"7","author":"Riaz","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neuroimage.2019.03.022","article-title":"On-scalp MEG system utilizing an actively shielded array of optically pumped magnetometers","volume":"194","author":"Iivanainen","year":"2019","journal-title":"Neuroimage"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zahran, S., Mahmoudzadeh, M., Wallois, F., Betrouni, N., Derambure, P., Le Prado, M., Palacios-Laloy, A., and Labyt, E. (2022). Performance Analysis of Optically Pumped 4He Magnetometers vs. Conventional SQUIDs: From Adult to Infant Head Models. Sensors, 22.","DOI":"10.3390\/s22083093"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Marhl, U., Sander, T., and Jazbin\u0161ek, V. (2022). Simulation study of different OPM-MEG measurement components. Sensors, 22.","DOI":"10.3390\/s22093184"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1002\/hbm.25586","article-title":"Optimal design of on-scalp electromagnetic sensor arrays for brain source localisation","volume":"42","author":"Beltrachini","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116099","DOI":"10.1016\/j.neuroimage.2019.116099","article-title":"Wearable neuroimaging: Combining and contrasting magnetoencephalography and electroencephalography","volume":"201","author":"Boto","year":"2019","journal-title":"NeuroImage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.neuroimage.2019.05.063","article-title":"Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography","volume":"199","author":"Tierney","year":"2019","journal-title":"NeuroImage"},{"key":"ref_23","unstructured":"(2022, July 11). QZFM Gen-3. Available online: https:\/\/quspin.com\/products-qzfm\/."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1088\/1361-6560\/aa6459","article-title":"Magnetocardiography measurements with 4He vector optically pumped magnetometers at room temperature","volume":"62","author":"Morales","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/TMI.2018.2856367","article-title":"Magnetoencephalography with optically pumped 4 He magnetometers at ambient temperature","volume":"38","author":"Labyt","year":"2018","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1364\/OE.420031","article-title":"Helium-4 magnetometers for room-temperature biomedical imaging: Toward collective operation and photon-noise limited sensitivity","volume":"29","author":"Fourcault","year":"2021","journal-title":"Opt. Express"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1002\/hbm.25582","article-title":"Evolution of MEG: A first MEG-feasible fluxgate magnetometer","volume":"42","author":"Koshev","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_28","unstructured":"Vetoshko, P. (2017). Remagnetization of Iron-Garnet Films by Coherent Rotation for Sensitive Elements of Magnetic Sensors. [Ph.D. Thesis, M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences (IMP UB RAS)]. (In Russian)."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"118025","DOI":"10.1016\/j.neuroimage.2021.118025","article-title":"Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system","volume":"236","author":"Brookes","year":"2021","journal-title":"NeuroImage"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1109\/10.553711","article-title":"Magnetoencephalography with diversely oriented and multicomponent sensors","volume":"44","author":"Hochwald","year":"1997","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1109\/10.16463","article-title":"Realistic conductivity geometry model of the human head for interpretation of neuromagnetic data","volume":"36","author":"Hamalainen","year":"1989","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_32","unstructured":"Ilmoniemi, R. (1985). Biomagnetism: Applications & Theory, Pergamon."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneumeth.2013.10.007","article-title":"Information content with low-vs. high-Tc SQUID arrays in MEG recordings: The case for high-Tc SQUID-based MEG","volume":"222","author":"Schneiderman","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21609","DOI":"10.1038\/s41598-020-77589-8","article-title":"Pragmatic spatial sampling for wearable MEG arrays","volume":"10","author":"Tierney","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117430","DOI":"10.1016\/j.neuroimage.2020.117430","article-title":"Spatial fidelity of MEG\/EEG source estimates: A general evaluation approach","volume":"224","author":"Samuelsson","year":"2021","journal-title":"Neuroimage"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1088\/0031-9155\/32\/1\/004","article-title":"Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem","volume":"32","author":"Sarvas","year":"1987","journal-title":"Phys. Med. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1103\/RevModPhys.65.413","article-title":"Magnetoencephalography: Theory, instrumentation, and applications to noninvasive studies of the working human brain","volume":"65","author":"Hamalainen","year":"1993","journal-title":"Rev. Mod. Phys."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1109\/TMAG.1970.1066765","article-title":"On the magnetic field generated outside an inhomogeneous volume conductor by internal current sources","volume":"6","author":"Geselowitz","year":"1970","journal-title":"IEEE Trans. Magn."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF02476917","article-title":"Considerations of quasi-stationarity in electrophysiological systems","volume":"29","author":"Plonsey","year":"1967","journal-title":"Bull. Math. Biophys."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"De Munck, J., Wolters, C., and Clerc, M. (2012). EEG and MEG: Forward Modeling, Cambridge University Press. Chapter 6.","DOI":"10.1017\/CBO9780511979958.006"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1162\/jocn.1993.5.2.162","article-title":"Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: A linear approach","volume":"5","author":"Sereno","year":"1993","journal-title":"J. Cogn. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0074-7742(05)68006-3","article-title":"Beamformer analysis of MEG data","volume":"68","author":"Hillebrand","year":"2005","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_43","first-page":"91","article-title":"Functional imaging with low-resolution brain electromagnetic tomography (LORETA): A review","volume":"24","author":"Esslen","year":"2002","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/nimg.1999.0454","article-title":"Visualization of magnetoencephalographic data using minimum current estimates","volume":"10","author":"Uutela","year":"1999","journal-title":"NeuroImage"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.20155","article-title":"Distributed current estimates using cortical orientation constraints","volume":"27","author":"Lin","year":"2006","journal-title":"Hum. Brain Mapp."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1134\/S1063785016080289","article-title":"Flux-gate magnetic field sensor based on yttrium-iron garnet films for magnetocardiography investigations","volume":"42","author":"Vetoshko","year":"2016","journal-title":"Tech. Phys. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10527-016-9628-9","article-title":"Rat Magnetocardiography Using a Flux-Gate Sensor Based on Iron Garnet Films","volume":"50","author":"Vetoshko","year":"2016","journal-title":"Biomed. Eng."},{"key":"ref_48","unstructured":"Kemppainen, P., and Ilmoniemi, R. (1989). Advances in Biomagnetism, Springer."},{"key":"ref_49","unstructured":"Osborne, J., Orton, J., Alem, O., and Shah, V. (February, January 29). Fully integrated standalone zero field optically pumped magnetometer for biomagnetism. Proceedings of the Steep Dispersion Engineering and Opto-Atomic Precision Metrology XI. International Society for Optics and Photonics, San Francisco, CA, USA."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1109\/TNSRE.2020.2968148","article-title":"Magnetic measurement of electrically evoked muscle responses with optically pumped magnetometers","volume":"28","author":"Elzenheimer","year":"2020","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.ijpsycho.2021.07.354","article-title":"How to Build OP-MEG: Specific Issues and Challenges","volume":"168","author":"Skidchenko","year":"2021","journal-title":"Int. J. Psychophysiol."},{"key":"ref_52","unstructured":"(2022, July 11). MNE-Python. Available online: https:\/\/mne.tools\/stable\/index.html."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1109\/TMI.2021.3119851","article-title":"Conservative finite element modeling of EEG and MEG on unstructured grids","volume":"41","author":"Yavich","year":"2021","journal-title":"IEEE Trans. Med. Imaging"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/9\/4256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:22:55Z","timestamp":1760124175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/23\/9\/4256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["s23094256"],"URL":"https:\/\/doi.org\/10.3390\/s23094256","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]}}}