{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:47:50Z","timestamp":1776001670343,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001288","name":"Parkinson\u2019s Foundation","doi-asserted-by":"publisher","award":["PF-FBS-1898-18-21"],"award-info":[{"award-number":["PF-FBS-1898-18-21"]}],"id":[{"id":"10.13039\/100001288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001288","name":"Parkinson\u2019s Foundation","doi-asserted-by":"publisher","award":["PF-CRA-2073"],"award-info":[{"award-number":["PF-CRA-2073"]}],"id":[{"id":"10.13039\/100001288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001288","name":"Parkinson\u2019s Foundation","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/100001288","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordenac\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["PF-FBS-1898-18-21"],"award-info":[{"award-number":["PF-FBS-1898-18-21"]}]},{"name":"Coordenac\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["PF-CRA-2073"],"award-info":[{"award-number":["PF-CRA-2073"]}]},{"name":"Coordenac\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Although the multifactorial nature of falls in Parkinson\u2019s disease (PD) is well described, optimal assessment for the identification of fallers remains unclear. Thus, we aimed to identify clinical and objective gait measures that best discriminate fallers from non-fallers in PD, with suggestions of optimal cutoff scores. METHODS: Individuals with mild-to-moderate PD were classified as fallers (n = 31) or non-fallers (n = 96) based on the previous 12 months\u2019 falls. Clinical measures (demographic, motor, cognitive and patient-reported outcomes) were assessed with standard scales\/tests, and gait parameters were derived from wearable inertial sensors (Mobility Lab v2); participants walked overground, at a self-selected speed, for 2 min under single and dual-task walking conditions (maximum forward digit span). Receiver operating characteristic curve analysis identified measures (separately and in combination) that best discriminate fallers from non-fallers; we calculated the area under the curve (AUC) and identified optimal cutoff scores (i.e., point closest-to-(0,1) corner). RESULTS: Single gait and clinical measures that best classified fallers were foot strike angle (AUC = 0.728; cutoff = 14.07\u00b0) and the Falls Efficacy Scale International (FES-I; AUC = 0.716, cutoff = 25.5), respectively. Combinations of clinical + gait measures had higher AUCs than combinations of clinical-only or gait-only measures. The best performing combination included the FES-I score, New Freezing of Gait Questionnaire score, foot strike angle and trunk transverse range of motion (AUC = 0.85). CONCLUSION: Multiple clinical and gait aspects must be considered for the classification of fallers and non-fallers in PD.<\/jats:p>","DOI":"10.3390\/s23104651","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T03:22:19Z","timestamp":1683775339000},"page":"4651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combination of Clinical and Gait Measures to Classify Fallers and Non-Fallers in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"23","author":[{"given":"Hayslenne A. G. O.","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"},{"name":"Department of Physical Therapy, State University of Londrina, Londrina 86057-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-9799","authenticated-orcid":false,"given":"Suhaila M.","family":"Smaili","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, State University of Londrina, Londrina 86057-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"},{"name":"Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Newcastle upon Tyne NE29 8NH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"},{"name":"Gateshead Health NHS Foundation Trust, Gateshead NE8 2PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6695","authenticated-orcid":false,"given":"Julia","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"},{"name":"Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Newcastle upon Tyne NE29 8NH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"McDonald","sequence":"additional","affiliation":[{"name":"Gateshead Health NHS Foundation Trust, Gateshead NE8 2PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-122X","authenticated-orcid":false,"given":"Richard","family":"Walker","sequence":"additional","affiliation":[{"name":"Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Newcastle upon Tyne NE29 8NH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"},{"name":"Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, Newcastle upon Tyne NE29 8NH, UK"},{"name":"Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-9452","authenticated-orcid":false,"given":"Rodrigo","family":"Vit\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Interventions for preventing falls in Parkinson\u2019s disease","volume":"6","author":"Allen","year":"2022","journal-title":"Cochrane Database Syst. 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