{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:27:46Z","timestamp":1775075266895,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"project \u2019BRIEF\u2014Biorobotics Research and Innovation Engineering Facilities\u2019","award":["J13C22000400007"],"award-info":[{"award-number":["J13C22000400007"]}]},{"name":"project \u2019BRIEF\u2014Biorobotics Research and Innovation Engineering Facilities\u2019","award":["RC2020-2022"],"award-info":[{"award-number":["RC2020-2022"]}]},{"name":"European Union","award":["J13C22000400007"],"award-info":[{"award-number":["J13C22000400007"]}]},{"name":"European Union","award":["RC2020-2022"],"award-info":[{"award-number":["RC2020-2022"]}]},{"name":"Italian Ministry of Health","award":["J13C22000400007"],"award-info":[{"award-number":["J13C22000400007"]}]},{"name":"Italian Ministry of Health","award":["RC2020-2022"],"award-info":[{"award-number":["RC2020-2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The study of visuomotor adaptation (VMA) capabilities has been encompassed in various experimental protocols aimed at investigating human motor control strategies and\/or cognitive functions. VMA-oriented frameworks can have clinical applications, primarily in the investigation and assessment of neuromotor impairments caused by conditions such as Parkinson\u2019s disease or post-stroke, which affect the lives of tens of thousands of people worldwide. Therefore, they can enhance the understanding of the specific mechanisms of such neuromotor disorders, thus being a potential biomarker for recovery, with the aim of being integrated with conventional rehabilitative programs. Virtual Reality (VR) can be entailed in a framework targeting VMA since it allows the development of visual perturbations in a more customizable and realistic way. Moreover, as has been demonstrated in previous works, a serious game (SG) can further increase engagement thanks to the use of full-body embodied avatars. Most studies implementing VMA frameworks have focused on upper limb tasks and have utilized a cursor as visual feedback for the user. Hence, there is a paucity in the literature about VMA-oriented frameworks targeting locomotion tasks. In this article, the authors present the design, development, and testing of an SG-based framework that addresses VMA in a locomotion activity by controlling a full-body moving avatar in a custom VR environment. This workflow includes a set of metrics to quantitatively assess the participants\u2019 performance. Thirteen healthy children were recruited to evaluate the framework. Several quantitative comparisons and analyses were run to validate the different types of introduced visuomotor perturbations and to evaluate the ability of the proposed metrics to describe the difficulty caused by such perturbations. During the experimental sessions, it emerged that the system is safe, easy to use, and practical in a clinical setting. Despite the limited sample size, which represents the main limitation of the study and can be compensated for with future recruitment, the authors claim the potential of this framework as a useful instrument for quantitatively assessing either motor or cognitive impairments. The proposed feature-based approach gives several objective parameters as additional biomarkers that can integrate the conventional clinical scores. Future studies might investigate the relation between the proposed biomarkers and the clinical scores for specific disorders such as Parkinson\u2019s disease and cerebral palsy.<\/jats:p>","DOI":"10.3390\/s23115017","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T01:59:13Z","timestamp":1684893553000},"page":"5017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Serious Game for the Assessment of Visuomotor Adaptation Capabilities during Locomotion Tasks Employing an Embodied Avatar in Virtual Reality"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5314-0093","authenticated-orcid":false,"given":"Vladimiro","family":"Suglia","sequence":"first","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-0983","authenticated-orcid":false,"given":"Antonio","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"},{"name":"Apulian Bioengineering s.r.l., 70026 Modugno, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-102X","authenticated-orcid":false,"given":"Guido","family":"Pasquini","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-293X","authenticated-orcid":false,"given":"Mariapia","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-1955","authenticated-orcid":false,"given":"Tommaso Maria","family":"Marvulli","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-7675","authenticated-orcid":false,"given":"Elena","family":"Sibilano","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-8102","authenticated-orcid":false,"given":"Sara","family":"Della Bella","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9083-8797","authenticated-orcid":false,"given":"Paola","family":"Carrozza","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}]},{"given":"Chiara","family":"Beni","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-8226","authenticated-orcid":false,"given":"David","family":"Naso","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-7553","authenticated-orcid":false,"given":"Vito","family":"Monaco","sequence":"additional","affiliation":[{"name":"The Biorobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant\u2019Anna, 56127 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-7799","authenticated-orcid":false,"given":"Giovanna","family":"Cristella","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-0788","authenticated-orcid":false,"given":"Vitoantonio","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"},{"name":"Apulian Bioengineering s.r.l., 70026 Modugno, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2024-5369","authenticated-orcid":false,"given":"Domenico","family":"Buongiorno","sequence":"additional","affiliation":[{"name":"Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, 70126 Bari, Italy"},{"name":"Apulian Bioengineering s.r.l., 70026 Modugno, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2012). 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