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Sensorimotor deficits are heterogeneous among stroke survivors. Previous work suggests a cause of hand deficits is altered neural connectivity. However, the relationships between neural connectivity and specific aspects of sensorimotor control have seldom been explored. Understanding these relationships is important for developing personalized rehabilitation strategies to improve individual patients\u2019 specific sensorimotor deficits and, thus, rehabilitation outcomes. Here, we investigated the hypothesis that specific aspects of sensorimotor control will be associated with distinct neural connectivity in chronic stroke survivors. Twelve chronic stroke survivors performed a paretic hand grip-and-relax task while EEG was collected. Four aspects of hand sensorimotor grip control were extracted, including reaction time, relaxation time, force magnitude control, and force direction control. EEG source connectivity in the bilateral sensorimotor regions was calculated in \u03b1 and \u03b2 frequency bands during grip preparation and execution. Each of the four hand grip measures was significantly associated with a distinct connectivity measure. These results support further investigations into functional neural connectivity signatures that explain various aspects of sensorimotor control, to assist the development of personalized rehabilitation that targets the specific brain networks responsible for the individuals\u2019 distinct sensorimotor deficits.<\/jats:p>","DOI":"10.3390\/s23125398","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:02:28Z","timestamp":1686189748000},"page":"5398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associating Functional Neural Connectivity and Specific Aspects of Sensorimotor Control in Chronic Stroke"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-0360","authenticated-orcid":false,"given":"Adam","family":"Baker","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, 77 President St., Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schranz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, 77 President St., Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-5905","authenticated-orcid":false,"given":"Na Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, 77 President St., Charleston, SC 29425, USA"},{"name":"Division of Occupational Therapy, Department of Rehabilitation Sciences, College of Health Professions, Medical University of South Carolina, 151B Rutledge Ave., Charleston, SC 29425, USA"},{"name":"Ralph H. Johnson VA Health Care System, 109 Bee St., Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"Collaborators","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1161\/01.STR.32.6.1279","article-title":"Estimates of the prevalence of acute stroke impairments and disability in a multiethnic population","volume":"32","author":"Lawrence","year":"2001","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/STROKEAHA.111.674671","article-title":"Patient-reported measures provide unique insights into motor function after stroke","volume":"44","author":"Stewart","year":"2013","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1161\/01.STR.0000183621.32045.31","article-title":"Long-term outcome in the North East Melbourne Stroke Incidence Study: Predictors of quality of life at 5 years after stroke","volume":"36","author":"Paul","year":"2005","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/jama.2013.13805","article-title":"The state of US health, 1990\u20132010: Burden of diseases, injuries, and risk factors","volume":"310","author":"Murray","year":"2013","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.apmr.2013.01.010","article-title":"Size doesn\u2019t matter: Cortical stroke lesion volume is not associated with upper extremity motor impairment and function in mild, chronic hemiparesis","volume":"94","author":"Page","year":"2013","journal-title":"Arch. 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